Q53 病毒性肝炎病毒容易变异吗？
所有病毒均存在一定频率的自发变异，通常RNA病毒的自发变异频率高于DNA病毒。各种肝炎病毒的自发变异频率如下：
· 甲型肝炎病毒（HAV）基因自发突变频率为1.73×10-4～9.76×10-4（/ 位点·年），低于其他小RNA科的病毒。
· 乙型肝炎病毒（HBV）基因自发突变频率为2.2×10-6～7.9×10-5（/ 位点·年）[4-6]，低于RNA病毒但明显高于其他DNA病毒。
· 丙型肝炎病毒（HCV）基因自发突变频率约为1.8×10-4（/ 位点·年）。
· 丁型肝炎病毒（HDV）基因自发突变频率约为3.18×10-3/ （位点·年）。
· 戊型肝炎病毒（HEV）基因自发突变频率约为1.4×10-3/ （位点·年）。
HBV和HCV在抗病毒治疗中变异发生的频率会明显增高。
（王蓓丽 潘柏申）
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