5.3　Specific Definition of CP Stage C

When it comes to Stage C，the end stage of CP，pancreatic fibrosis has led to specified clinical exocrine and/or endocrine pancreatic function loss（e.g.stage C steatorrhea and/or diabetes mellitus）with/without complications.There are three sub-classified categories of Stage C:“C1-patients with endocrine function impairment；C2-patients with exocrine function impairment；C3-patients with exocrine/endocrine function impairment and/or complications”.(https://www.daowen.com)

Patients with clinical manifestation of endstage functional impairment with/without complications may be divided as Stage C（Milosavljevic et al.2010）.