6.2　Autoimmune Diseases

In the last 10 years it has been reported an increasing number of cases of autoimmune pancreatitis（AIP）in all countries around the world（Pearson et al.2003）；the frequency of autoimmune pancreatitis will probably increase in the next few years.Autoimmune pancreatitis is clinically characterized by obstructive jaundice and，histologically，by a lymphoplasmacytic infiltrate with fibrosis；from a therapeutic point of view，there is a dramatic response to corticosteroid therapy.Several classifications of autoimmune pancreatitis have been proposed（Fantini et al.2007）.Recently，two distinct diseases have been identified:one is called type 1 and the other one，type 2 AIP（Hart et al.2015）.Type 1 AIP is the pancreatic manifestation of immunoglobulin G4-related disease whereas type 2 AIP is less commonly recognized has no biomarker and may be associated with inflammatory bowel disease in about 1/4 of patients（Hart et al.2015）.(https://www.daowen.com)