References
Acioli JM,Isobe M,Kawasaki S.Early complement system activation and neutrophil priming in acute pancreatitis: participation of trypsin.Surgery.1997;122(5):909-17.
Addadi L,Weiner S.Interaction between acidic proteins and crystals:stereochemical requirements in biomineralization.PNAS.1985;82:4110-4.
Aghdassi A,Mayerle J,Kraft M,Sielenkamper AW,Heidecke C-DD,Lerch MM.Diagnosis and treatment of pancreatic pseudocysts in chronic pancreatitis.Pancreas.2008;36:105-12.
Aghdassi AA,Mayerle J,Christochowitz S,Weiss FU,Sendler M,Lerch MM.Animal models for investigating chronic pancreatitis.Fibrogenesis Tissue Repair.2011;4(1):26.doi:10.1186/1755-1536-4-26.
Aghdassi AA,Weiss FU,Mayerle J,Lerch MM,Simon P.Genetic susceptibility factors for alcohol-induced chronic pancreatitis.Pancreatology.2015;15(4 Suppl):523-31.doi:10.1016/j.pan.2015.05.476.
Allan J,White TT.An alternate mechanism for the formation of protein plugs in chronic calcifying pancreatitis.Digestion.1974;11:428-31.
Ammann RW,Akovbiantz A,Largiader F,Schueler G.Course and outcome of chronic pancreatitis.Longitudinal study of a mixed medical-surgical series of 245 patients.Gastroenterology.1984;86:820-8.
Ammann RW,Muellhaupt B,Meyenberger C,Heitz PU.Alcoholic nonprogressive chronic pancreatitis:prospective long-term study of a large cohort with alcoholic acute pancreatitis(1976-1992).Pancreas.1994;9(3):365-73.
Ammann RW,Heitz PU,Kloppel G.Course of alcoholic chronic pancreatitis:a prospective clinicomorphological long-term study.Gastroenterology.1996;111(1):224-31.
Anand P,Aziz Q,Willert R,van Oudenhove L.Peripheral and central mechanisms of visceral sensitization in man.Neurogastroenterol Motil.2007;19:29-46.
Anaparthy R,Pasricha PJ.Pain and chronic pancreatitis:is it the plumbing or the wiring?Curr Gastroenterol Rep.2008;10:101-6.
Anderson MA,Akshintala V,Albers KM,et al.Mechanism,assessment and management of pain in chronic pancreatitis:recommendations of a multidisciplinary study group.Pancreatology.2015;16:83-94.
Andrén-Sandberg A,Dervenis C.Pancreatic pseudocysts in the 21st century.Part I:classification,pathophysiology,anatomic considerations and treatment.JOP.2004;5:8-24.
Andrews BS,Eisenberg RA,Theofilopoulos AN,et al.Spontaneous murine lupus-like syndromes.Clinical and immunopathological manifestations in several strains.J Exp Med.1978;148(5):1198-215.
Apkarian AV,Hashmi JA,Baliki MN.Pain and the brain:specificity and plasticity of the brain in clinical chronic pain.Pain.2011;152:S49-64.
Apte MV,Haber PS,Darby SJ,et al.Pancreatic stellate cells are activated by proinflammatory cytokines:implications for pancreatic fibrogenesis.Gut.1999;44(4):534-41.
Apte MV,Phillips PA,Fahmy RG,et al.Does alcohol directly stimulate pancreatic fibrogenesis?Studies with rat pancreatic stellate cells.Gastroenterology.2000;118(4):780-94.
Archer H,Jura N,Keller J,Jacobson M,Bar-Sagi D.A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen.Gastroenterology.2006;131(6):1844-55.doi:10.1053/j.gastro.2006.09.049.
Backonja M,Wallace MS,Blonsky ER,Cutler BJ,Malan P Jr,Rauck R,Tobias J.NGX-4010,a highconcentration capsaicin patch,for the treatment of postherpetic neuralgia:a randomised,double-blind study.Lancet Neurol.2008;7:1106-12.
Balci NC,Perman WH,Saglam S,Akisik F,Fattahi R,Bilgin M.Diffusion-weighted magnetic resonance imaging of the pancreas.Top Magn Reson Imaging.2009;20:43-7.
Bertelli E,Bendayan M.Intermediate endocrine-acinar pancreatic cells in duct ligation conditions.Am J Phys.1997;273(5 Pt 1):C1641-9.
Bimmler D,Graf R,Scheele GA,et al.Pancreatic stone protein(lithostathine),a physiologically relevant pancreatic calcium carbonate crystal inhibitor?J Biol Chem.1997;272:3073-82.
Bockman DE,Kennedy RH,Multigner L,et al.Fine structure of the organic matrix of human pancreatic stones.Pancreas.1986;1:204-10.
Bockman DE,Buchler M,Malfertheiner P,Beger HG.Analysis of nerves in chronic pancreatitis.Gastroenterology.1988;94:1459-69.
Boerma D,Obertop H,Gouma DJ.Pancreatic pseudocysts in chronic pancreatitis.Surgical or interventional drainage?Ann Ital Chir.2000;71:43-50.
Bornman PC,Marks IN,Girdwood AH,Clain JE,Narunsky L,Clain DJ,Wright JP.Is pancreatic duct obstruction or stricture a major cause of pain in calcific pancreatitis?Br J Surg.1980;67:425-8.
Bourdi M,Davies JS,Pohl LR.Mispairing C57BL/6 substrains of genetically engineered mice and wild-type controls can lead to confounding results as it did in studies of JNK2 in acetaminophen and concanavalin A liver injury.Chem Res Toxicol.2011;24(6):794-6.doi:10.1021/tx200143x.
Bouwense SA,Buscher HC,van Goor H,Wilder-Smith OH.S-ketamine modulates hyperalgesia in patients with chronic pancreatitis pain.Reg Anesth Pain Med.2011a;36:303-7.
Bouwense SA,Buscher HC,van Goor H,Wilder-Smith OH.Has central sensitization become independent of nociceptive input in chronic pancreatitis patients who fail thoracoscopic splanchnicectomy?Reg Anesth Pain Med.201lb;36:531-6.
Bouwense SA,Olesen SS,Drewes AM,Frøkjær JB,van Goor H,Wilder-Smith OH.Is altered central pain processing related to disease stage in chronic pancreatitis patients with pain?An exploratory study.PLoS One.2013;8:e55460.
Brock C,Olesen SS,Olesen AE,Frokjaer JB,Andresen T,Drewes AM,Frøkjaer JB,Andresen T,Drewes AM.Opioid-induced bowel dysfunction:pathophysiology and management.Drugs.2012;72:1847-65.
Brock C,Nielsen LM,Lelic D,Drewes AM.Pathophysiology of chronic pancreatitis.World J Gastroenterol.2013;19(42):7231-40.doi:10.3748/wjg.v19.i42.7231.
Büchler M,Weihe E,Friess H,Malfertheiner P,Bockman E,Müller S,Nohr D,Beger HG.Changes in peptidergic innervation in chronic pancreatitis.Pancreas.1992;7:183-92.
Buscher HC,Wilder-Smith OH,van Goor H.Chronic pancreatitis patients show hyperalgesia of central origin:a pilot study.Eur J Pain.2006;10:363-70.
Cano DA,Sekine S,Hebrok M.Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis.Gastroenterology.2006;131(6):1856-69.doi:10.1053/j.gastro.2006.10.050.
Casellas F,Guarner L,Vaquero E,Antolin M,de Gracia X,Malagelada JR.Hydrogen breath test with glucose in exocrine pancreatic insufficiency.Pancreas.1998;16:481-6.
Ceyhan GO,Deucker S,Demir IE,et al.Neural fractalkine expression is closely linked to pain and pancreatic neuritis in human chronic pancreatitis.Lab Invest.2009a;89:347-61.
Ceyhan GO,Demir IE,Rauch U,Bergmann F,Müller MW,Biichler MW,Friess H,Schäfer K-H.Pancreatic neuropathy results in“neural remodeling”and altered pancreatic innervation in chronic pancreatitis and pancreatic cancer.Am J Gastroenterol.2009b;104:2555-65.
Ceyhan GO,Bergmann F,Kadihasanoglu M,et al.Pancreatic neuropathy and neuropathic pain—a comprehensive pathomorphological study of 546 cases.Gastroenterology.2009c;136:177-186.e l.
Chebli JM,de Souza AF,Gaburri PD,Bastos KV,Ribeiro TC,Filho RJ,Chebli LA,Castro Ferreira LE.Prevalence and pathogenesis of duodenal ulcer in chronic alcoholic pancreatitis.J Clin Gastroenterol.2002;35:71-4.
Chen JM,Ferec C.Genetics and pathogenesis of chronic pancreatitis:the 2012 update.Clin Res Hepatol Gastroenterol.2012;36(4):334-40.doi:10.1016/j.clinre.2012.05.003.
Churg A,Richter WR.Early changes in the exocrine pancreas of the dog and rat after ligation of the pancreatic duct.A light and electron microscopic study.Am J Pathol.1971;63(3):521-46.
Cohn JA,Friedman KJ,Noone PG,Knowles MR,Silverman LM,Jowell PS.Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis.N Engl J Med.1998;339(10):653-8.doi:10.1056/NEJM199809033391002.
Colomer V,Lal K,Hoops TC,et al.Exocrine granule specific packaging signals are present in the polypeptide moiety of the pancreatic granule membrane protein GP2 and in amylase:implications for protein targeting to secretory granules.EMBO J.1994;13(16):3711-9.
Criddle DN.The role of fat and alcohol in acute pancreatitis:a dangerous liaison.Pancreatology.2015;15(4 Suppl):S6-12.doi:10.1016/j.pan.2015.02.009.
Criddle DN,Murphy J,Fistetto G,et al.Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis.Gastroenterology.2006;130(3):781-93.doi:10.1053/j.gastro.2005.12.031.
De Caro A,Lohse J,Sarles H.Characterization of a protein isolated from pancreatic calculi of men suffering from chronic calcifying pancreatitis.Biochem Biophys Res Commun.1979;87:1176-82.
De Reggi M,Gharib B,Patard L,et al.Lithostathine,the presumed pancreatic stone inhibitor,does not interact specifically with calcium carbonate crystals.J Biol Chem.1998;273:4967-71.
Demir IE,Friess H,Ceyhan GO.Neural plasticity in pancreatitis and pancreatic cancer.Nat Rev Gastroenterol Hepatol.2015;12:649-59.
Deng X,Wang L,Elm MS,et al.Chronic alcohol consumption accelerates fibrosis in response to cerulein-induced pancreatitis in rats.Am J Pathol.2005;166(1):93-106.doi:10.1016/S0002-9440(10)62235-3.
Derikx MH,Kovacs P,Scholz M,et al.Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.Gut.2015;64(9):1426-33.doi:10.1136/gutjnl-2014-307453.
Detlefsen S,Sipos B,Feyerabend B,Kloppel G.Fibrogenesis in alcoholic chronic pancreatitis:the role of tissue necrosis,macrophages,myofibroblasts and cytokines.Mod Pathol.2006;19(8):1019-26.doi:10.1038/modpathol.3800613.
Di Sebastiano P,Fink T,Weihe E,Friess H,Innocenti P,Beger HG,Büchler MW.Immune cell infiltration and growth-associated protein 43 expression correlate with pain in chronic pancreatitis.Gastroenterology.1997;112:1648-55.
Dimagno MJ,Lee SH,Hao Y,Zhou SY,McKenna BJ,Owyang C.A proinflammatory,antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator(-/-)mice.Gastroenterology.2005;129(2):665-81.doi:10.1016/j.gastro.2005.05.059.
Dimcevski G,Sami SA,Funch-Jensen P,Le Pera D,Valeriani M,Arendt-Nielsen L,Drewes AM.Pain in chronic pancreatitis:the role of reorganization in the central nervous system.Gastroenterology.2007;132:1546-56.
Drewes A-M.Is the pain in chronic pancreatitis of neuropathic origin?Support from EEG studies during experimental pain.World J Gastroenterol.2008;14:4020.
Durie PR,Kent G,Phillips MJ,Ackerley CA.Characteristic multiorgan pathology of cystic fibrosis in a long-living cystic fibrosis transmembrane regulator knockout murine model.Am J Pathol.2004;164(4):1481-93.doi:10.1016/S0002-9440(10)63234-8.
Ebbehøj N,Svendsen LB,Madsen P.Pancreatic tissue pressure:techniques and pathophysiological aspects.Scand J Gastroenterol.1984;19:1066-8.
Ebbehøj N,Borly L,Bülow J,Rasmussen SG,Madsen P,Matzen P,Owre A.Pancreatic tissue fluid pressure in chronic pancreatitis.Relation to pain,morphology,and function.Scand J Gastroenterol.1990a;25:1046-51.
Ebbehøj N,Borly L,Bülow J,Rasmussen SG,Madsen P.Evaluation of pancreatic tissue fluid pressure and pain in chronic pancreatitis.A longitudinal study.Scand J Gastroenterol.1990b;25:462-6.
Elsasser HP,Haake T,Grimmig M,Adler G,Kern HE Repetitive cerulein-induced pancreatitis and pancreatic fibrosis in the rat.Pancreas.1992;7(3):385-90.
Esposito I,Friess H,Kappeler A,Shrikhande S,Kleeff J,Ramesh H,Zimmermann A,Büchler MW.Mast cell distribution and activation in chronic pancreatitis.Hum Pathol.2001;32:1174-83.
Farnbacher MJ,Voll RE,Faissner R,et al.Composition of clogging material in pancreatic endoprostheses.Gastrointest Endosc.2005;61:862-6.
Fasanella KE,Davis B,Lyons J,Chen Z,Lee KK,Slivka A,Whitcomb DC.Pain in chronic pancreatitis and pancreatic cancer.Gastroenterol Clin North Am.2007;36:335-64,ix.
Flor H,Elbert T,Knecht S,Wienbruch C,Pantev C,Birbaumer N,Larbig W,Taub E.Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation.Nature.1995;375:482-4.
Flor H,Nikolajsen L,Jensen TS.Phantom limb pain:a case of maladaptive CNS plasticity?Nat Rev Neurosci.2006;7:873-81.
Freedman SD,Kern HF,Scheele GA.Apical membrane trafficking during regulated pancreatic exocrine secretion—role of alkaline pH in the acinar lumen and enzymatic cleavage of GP2,a GPI-linked protein.Eur J Cell Biol.1994;65:354-65.
Freedman SD,Kern HF,Scheele GA.Pancreatic acinar cell dysfunction in CFTR(-/-)mice is associated with impairments in luminal pH and endocytosis.Gastroenterology.2001;121(4):950-7.
Friess H,Shrikhande S,Shrikhande M,Martignoni M,Kulli C,Zimmermann A,Kappeler A,Ramesh H,Büchler M.Neural alterations in surgical stage chronic pancreatitis are independent of the underlying aetiology.Gut.2002;50:682-6.
Frokjaer JB,Drewes AM,Olesen SS,Frøkjær JB,Olesen SS,Drewes AM.Fibrosis,atrophy,and ductal pathology in chronic pancreatitis are associated with pancreatic function but independent of symptoms.Pancreas.2013;42:1182-7.
Frøkjaer JB,Olesen SS,Gram M,Yavarian Y,Bouwense SA,Wilder-Smith OH,Drewes AM.Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis.Gut.2011;60:1554-62.
Frøkjaer JB,Bouwense SA,Olesen SS,Lundager FH,Eskildsen SF,van Goor H,Wilder-Smith OH,Drewes AM.Reduced cortical thickness of brain areas involved in pain processing in patients with chronic pancreatitis.Clin Gastroenterol Hepatol.2012;10:434-8.el.
Frulloni L,Gabbrielli A,Pezzilli R,et al.Chronic pancreatitis:report from a multicenter Italian survey(PanCroInfAISP)on 893 patients.Dig Liver Dis.2009;41(4):311-7.doi:10.1016/j.dld.2008.07.316.
Gebhart GF.Visceral pain-peripheral sensitisation.Gut.2000;47(Suppl 4):iv54-5,discussion iv58.
Gebhart GF.Descending modulation of pain.Neurosci Biobehav Rev.2004;27:729-37.
Gebhart GF.It's chickens and eggs all over again:is central reorganization the result or cause of persistent visceral pain?Gastroenterology.2007;132:1618-20.
Geider S,Baronnet A,Cerini C,et al.Pancreatic lithostathine as a calcite habit modifier.J Biol Chem.1996;271:26302-6.
Gerasimenko JV,Lur G,Sherwood MW,et al.Pancreatic protease activation by alcohol metabolite depends on Ca2+release via acid store 1P3 receptors.Proc Natl Acad Sci U S A.2009;106(26):10758-63.doi:10.1073/pnas.0904818106.
Goto M,Nakano I,Kimura T,Miyahara T,Kinjo M,Nawata H.New chronic pancreatitis model with diabetesinduced by cerulein plus stress in rats.Dig Dis Sci.1995;40(11):2356-63.
Gouyon B,Lévy P,Ruszniewski P,Zins M,Hammel P,Vilgrain V,Sauvanet A,Belghiti J,Bernades P.Predictive factors in the outcome of pseudocysts complicating alcoholic chronic pancreatitis.Gut.1997;41:821-5.
Graversen C,Olesen SS,Olesen AE,Steimle K,Farina D,Wilder-Smith OHG,Bouwense SAW,van Goor H,Drewes AM.The analgesic effect of pregabalin in patients with chronic pain is reflected by changes in pharmaco-EEG spectral indices.Br J Clin Pharmacol.2012;73:363-72.
Gress T,Muller-Pillasch F,Elsasser HP,et al.Enhancement of transforming growth factor beta 1 expression in the rat pancreas during regeneration from caerulein-induced pancreatitis.Eur J Clin Investig.1994;24(10):679-85.
Grippo PJ,Venkatasubramanian PN,Knop RH,et al.Visualization of mouse pancreas architecture using MR microscopy.Am J Pathol.2011;179(2):610-8.doi:10.1016/j.ajpath.2011.04.007.
Gross J,Carlson RI,Brauer AW,et al.Isolation,characterization,and distribution of an unusual pancreatic human secretory protein.J Clin Invest.1985;76:2115-26.
Gukovskaya AS,Mareninova OA,Odinokova IV,et al.Cell death in pancreatitis:effects of alcohol.J Gastroenterol Hepatol.2006;21(Suppl 3):S10-3.doi:10.1111/j.1440-1746.2006.04571.x.
Gukovsky I,Lugea A,Shahsahebi M,et al.A rat model reproducing key pathological responses of alcoholic chronic pancreatitis.Am J Physiol Gastrointest Liver Physiol.2008;294(1):G68-79.doi:10.1152/ajpgi.00006.2007.
Gupte AR,Forsmark CE.Chronic pancreatitis.Curr Opin Gastroenterol.2014;30(5):500-5.doi:10.1097/MOG.0000000000000094.
Halangk W,Lerch MM,Brandt-Nedelev B,et al.Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.J Clin Invest.2000;106(6):773-81.doi:10.1172/JCI9411.
Harada H,Ueda O,Kochi F,Kobayashi T,Komazawa M.Comparative studies on viscosity and concentration of protein and hexosamine in pure pancreatic juice.Gastroenterol Jpn.1981;16(6):623-6.
Harding HP,Zeng H,Zhang Y,et al.Diabetes mellitus and exocrine pancreatic dysfunction in perk-/-mice reveals a role for translational control in secretory cell survival.Mol Cell.2001;7(6):1153-63.
Haroutounian S,Nikolajsen L,Bendtsen TF,Finnerup NB,Kristensen AD,Hasselstrom JB,Jensen TS.Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy.Pain.2014;155:1272-9.
Hartel M,di Mola FF,Selvaggi F,et al.Vanilloids in pancreatic cancer:potential for chemotherapy and pain management.Gut.2006;55:519-28.
Hayakawa T,Harada H,Noda A,et al.Lactoferrin in pure pancreatic juice in chronic pancreatitis.Am J Gastroenterol.1983;78(4):222.
Hayakawa T,Kondo T,Shibata T,et al.Trypsin(ogen)content of pancreatic calculi in chronic calcified pancreatitis in man.Dig Dis Sci.1994;39:1345-50.
Heinricher MM,Tavares I,Leith JL,Lumb BM.Descending control of nociception:specificity,recruitment and plasticity.Brain Res Rev.2009;60:214-25.
Hillebrandt S,Wasmuth HE,Weiskirchen R,et al.Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans.Nat Genet.2005;37(8):835-43.doi:10.1038/ng1599.
Hingorani SR,Wang L,Multani AS,et al.Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.Cancer Cell.2005;7(5):469-83.doi:10.1016/j.ccr.2005.04.023.
Hoogerwerf WA,Gondesen K,Xiao S-Y,Winston JH,Willis WD,Pasricha PJ.The role of mast cells in the pathogenesis of pain in chronic pancreatitis.BMC Gastroenterol.2005;5:8.
Huang W,Booth DM,Cane MC,et al.Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis.Gut.2014;63(8):1313-24.doi:10.1136/gutjnl-2012-304058.
Hughes MS,Shenoy M,Liu L,Colak T,Mehta K,Pasricha PJ.Brain-derived neurotrophic factor is upregulated in rats with chronic pancreatitis and mediates pain behavior.Pancreas.2011;40:551-6.
limuro Y,Frankenberg MV,Arteel GE,Bradford BU,Wall CA,Thurman RG.Female rats exhibit greater susceptibility to early alcohol-induced liver injury than males.Am J Phys.1997;272(5 Pt l):G1186-94.
Irving HM,Samokhvalov AV,Rehm J.Alcohol as a risk factor for pancreatitis.A systematic review and metaanalysis.JOP.2009;10(4):387-92.
Isaksson G,Lundquist I,Ihse I.Effects on the exocrine and endocrine pancreas of duct occlusion with two different tissue glues in the rat.Eur Surg Res.1983;15(3):136-44.
Jensen AR,Matzen P,Malchow-Møller A,Christoffersen 1.Pattern of pain,duct morphology,and pancreatic function in chronic pancreatitis.A comparative study.Scand J Gastroenterol.1984;19:334-8.
Jin CX,Naruse S,Kitagawa M,et al.Pancreatic stone protein of pancreatic calculi in chronic calcified pancreatitis in man.JOP.2002;3:54-61.
Juel J,Olesen SS,Olesen AE,Poulsen JL,Dahan A,Wilder-Smith O,Madzak A,Frøkjær JB,Drewes AM.Study protocol for a randomised,double-blinded,placebo-controlled,clinical trial of S-ketamine for pain treatment in patients with chronic pancreatitis(RESET trial).BMJ Open.2015;5:e007087.
Kahl S,Zimmermann S,Genz I,Schmidt U,Pross M,Schulz HU,Malfertheiner P.Biliary strictures are not the cause of pain in patients with chronic pancreatitis.Pancreas.2004;28:387-90.
Kalvaria I,Bomman PC,Marks IN,Girdwood AH,Bank L,Kottler RE.The spectrum and natural history of common bile duct stenosis in chronic alcohol-induced pancreatitis.Ann Surg.1989;210:608-13.
Kanno H,Nose M,Itoh J,Taniguchi Y,Kyogoku M.Spontaneous development of pancreatitis in the MRL/Mp strain of mice in autoimmune mechanism.Clin Exp Immunol.1992;89(1):68-73.
Kara ME.The anatomical study on the rat pancreas and its ducts with emphasis on the surgical approach.Ann Anat.2005;187(2):105-12.doi:10.1016/j.aanat.2004.10.004.
Keith RG,Keshavjee SH,Kerenyi NR.Neuropathology of chronic pancreatitisin humans.Can Jsurgery.1985;28:207-11.
Keller J,Aghdassi AA,Lerch MM,Mayerle JV,Layer P.Tests of pancreatic exocrine function—clinical significance in pancreatic and non-pancreatic disorders.Best Pract Res Clin Gastroenterol.2009;23(3):425-39.doi:10.1016/j.bpg.2009.02.013.
Kimura Y,Torimura T,Ueno T,Inuzuka S,Tanikawa K.Transforming growth factor beta 1,extracellular matrix,and inflammatory cells in wound repair usinga closed duodenal loop pancreatitis model rat.Immunohistochemical study.Scand J Gastroenterol.1995;30(7):707-14.
Kishi S,Takeyama Y,Ueda T,et al.Pancreatic duct obstruction itself induces expression of alpha smooth muscle actin in pancreatic stellate cells.J Surg Res.2003;114(1):6-14.
Klöppel G.Chronic pancreatitis,pseudotumors and other tumor-like lesions.Mod Pathol.2007;20(Suppl 1):5113-31.doi:10.1038/modpathol.3800690.
Klöppel G.Histopathologie der chronischen Pankreatitis.In:Beger HG,Büchler MW,Dralle H,Lerch MM,Malfertheiner P,Mössner J,Riemann JF,editors.Erkrankungen des Pankreas.Berlin:Springer;2013.p.86-91.
Kloppel G,Detlefsen S,Feyerabend B.Fibrosis of the pancreas:the initial tissue damage and the resulting pattern.Virchows Arch.2004;445(l):1-8.doi:10.1007/s00428-004-1021-5.
Kohl J.Anaphylatoxins and infectious and noninfectious inflammatory diseases.Mol Immunol.2001;38(2-3):175-87.
Kono H,Nakagami M,Rusyn I,et al.Development of an animal model of chronic alcohol-induced pancreatitis in the rat.Am J Physiol Gastrointest Liver Physiol.2001;280(6):G 1178-86.
Lampel M,Kern HE Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue.Virchows Arch A Pathol Anat Histol.1977;373(2):97-117.
Lankisch PG,Löhr-Happe A,Otto J,Creutzfeldt W.Natural course in chronic pancreatitis.Pain,exocrine and endocrine pancreatic insufficiency and prognosis of the disease.Digestion.1993;54:148-55.
Lankisch PG,Breuer N,Bruns A,Weber-Dany B,Lowenfels AB,Maisonneuve P.Natural history of acute pancreatitis:a long-term population-based study.Am J Gastroenterol.2009;104(11):2797-2805.;,quiz 2806.doi:10.1038/ajg.2009.405.
Latremoliere A,Woolf CJ.Central sensitization:a generator of pain hypersensitivity by central neural plasticity.J Pain.2009;10:895-926.
Laugier R.Dynamic endoscopic manometry of the response to secretin in patients with chronic pancreatitis.Endoscopy.1994;26:222-7.(https://www.daowen.com)
Layer PH.Motor cycles and other cycles in chronic pancreatitis.Gastroenterology.1995;109:316-9.
Lelic D,Olesen SS,Hansen TM,Valeriani M,Drewes AM.Functional reorganization of brain networks in patients with painful chronic pancreatitis.Eur J Pain.2014;doi:10.1002/j.1532-2149.2013.00442.x.
Lerch MM,Gorelick FS.Models of acute and chronic pancreatitis.Gastroenterology.2013;144(6):1180-93.doi:10.1053/j.gastro.2012.12.043.
Levy P,Dominguez-Munoz E,Imrie C,Lohr M,Maisonneuve P.Epidemiology of chronic pancreatitis:burden of the disease and consequences.United European Gastroenterol J.2014;2(5):345-54.doi:10.1177/2050640614548208.
Li J,Guo M,Hu B,Liu R,Wang R,Tang C.Does chronic ethanol intake cause chronic pancreatitis?:evidence and mechanism.Pancreas.2008;37(2):189-95.doi:10.1097/MPA.0b013e31816459b7.
Lieb JG II,Forsmark CE,Lieb JG,Forsmark CE.Review article:pain and chronic pancreatitis.Aliment Pharmacol Ther.2009;29:706-19.
Lieber CS,DeCarli LM.Liquid diet technique of ethanol administration:1989 update.Alcohol Alcohol.1989;24(3):197-211.
Lieber CS,Jones DP,Decarli LM.Effects of prolonged ethanol intake:production of fatty liver despite adequate diets.J Clin Invest.1965;44:1009-21.doi:10.1172/JCI105200.
Liu L,Shenoy M,Pasricha PJ.Substance P and calcitonin gene related peptide mediate pain in chronic pancreatitis and their expression is driven by nerve growth factor.JOP.2011;12:389-94.
Lohse J,Kraemer R.Calcium binding to the“stone protein”isolated from pancreatic stones of patients with chronic calcified pancreatitis.Hoppe Seylers Z Physiol Chem.1984;365:549-54.
Lohse J,Vernie HJ,Sarles H.Studies on pancreatic stones.I.In vitro dissolution.Digestion.1981;21:125-32.
Lugea A,Gukovsky I,Gukovskaya AS,Pandol SJ.Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas.Gastroenterology.2003;125(6):1845-59.
Lugea A,Gong J,Nguyen J,Nieto J,French SW,Pandol SJ.Cholinergic mediation of alcohol-induced experimental pancreatitis.Alcohol Clin Exp Res.2010;34(10):1768-81.doi:10.1111/j.1530-0277.2010.01264.x.
Malfertheiner P,Büehler M,Stanescu A,Ditschuneit H.Pancreatic morphology and function in relationship to pain in chronic pancreatitis.Int J Pancreatol.1987;2:59-66.
Manes G,Büehler M,Pieramico O,Di Sebastiano P.Malfertheiner P.Is increased pancreatic pressure related to pain in chronic pancreatitis?Int J Pancreatol.1994;15:113-7.
Mariani A,Bernard JP,Provansal-Cheylan M,et al.Differences of pancreatic stone morphology and content in patients with pancreatic lithiasis.Dig Dis Sci.1991;36:1509-16.
Marrache F,Tu SP,Bhagat G,et al.Overexpression of interleukin-lbetainthemurinepancreasresultsinchronic pancreatitis.Gastroenterology.2008;135(4):1277-87.doi:10.1053/j.gastro.2008.06.078.
McIlwrath SL,Westlund KN.Pharmacological attenuationof chronic alcoholic pancreatitis induced hypersensitivity in rats.World J Gastroenterol.2015;21(3):836-53.doi:10.3748/wjg.v21.i3.836.
Meier T,Wasner G,Faust M,Kuntzer T,Ochsner F,Hueppe M,Bogousslavsky J,Baron R.Efficacy of lidocaine patch 5%in the treatment of focal peripheral neuropathic pain syndromes:a randomized,double-blind,placebo-controlled study.Pain.2003;106:151-8.
Menke A,Yamaguchi H,Gress TM,Adler G.Extracellular matrix is reduced by inhibition of transforming growth factor betal in pancreatitis in the rat.Gastroenterology.1997;113(1):295-303.
Miyahara T,Kawabuchi M,Goto M,Nakano I,Nada 0,Nawata H.Morphological study of pancreatic endocrine in an experimental chronic pancreatitis with diabetes induced by stress and cerulein.Ultrastruct Pathol.1999;23(3):171-80.
Miyauchi M,Suda K,Kuwayama C,Abe H,Kakinuma C.Role of fibrosis-related genes and pancreatic duct obstruction in rat pancreatitis models:implications for chronic pancreatitis.Histol Histopathol.2007;22(10):1119-27.
Moran RA,James T,Pasricha PJ.Pancreatic pain.Curr Opin Gastroenterol.2015;31:407-15.
Mori M,Fu X,Chen L,Zhang G,Higuchi K.Hereditary pancreatitis model WBN/Kob rat strain has a unique haplotype in the Pdwkl region on chromosome 7.Exp Anim.2009;58(4):409-13.
Mullady DK,Yadav D,Amann ST,et al.Type of pain,pain-associated complications,quality of life,disability and resource utilisation in chronic pancreatitis:a prospective cohort study.Gut.2011;60:77-84.
Multigner L,Daudon M,Montalto G,et al.Radiolucent pancreatic stones.New Engl J Med.1986;314:248.
Muniraj T,Aslanian HR,Farrell J,Jamidar PA.Chronic pancreatitis,a comprehensive review and update.Part I:epidemiology,etiology,risk factors,genetics,pathophysiology,and clinical features.Dis Mon.2014;60(12):530-50.doi:10.1016/j.disamonth.2014.11.002.
Nagai H,Ohtsubo K.Pancreatic lithiasis in the aged.Its clinicopathology and pathogenesis.Gastroenterology.1984;86:331-8.
Nakamura M,Oka M,Iizuka N,et al.Osteopontin expression in chronic pancreatitis.Pancreas.2002;25:182-7.
Nakayama S,Nishio A,Yamashina M,et al.Acquired immunity plays an important role in the development of murine experimental pancreatitis induced by alcohol and lipopolysaccharide.Pancreas.2014;43(1):28-36.doi:10.1097/MPA.0b013e3182a7c76b.
Neuschwander-Tetri BA,Bridle KR,Wells LD,Marcu M,Ramm GA.Repetitive acute pancreatic injury in the mouse induces procollagen alphal(I)expression colocalized to pancreatic stellate cells.Lab Investig.2000a;80(2):143-50.
Neuschwander-Tetri BA,Burton FR,Presti ME,et al.Repetitive self-limited acute pancreatitis induces pancreatic fibrogenesis in the mouse.Dig Dis Sci.2000b;45(4):665-74.
Noda A,Hayakawa T,Kondo T,et al.Pancreatic stones dissolution with dimethadione(DMO).I.In vitro dissolution.Jpn J Gastroenterol.1984;81:101-7.
Noda A,Ibuki E,Murayama H,Hase S.Bromhexine hydrochloride eliminates protein plugs and relieves attacks of pancreatitis.Pancreas.1997;15:209-11.
Novis BH,Bornman PC,Girdwood AW,Marks IN.Endoscopic manometry of the pancreatic duct and sphincter zone in patients with chronic pancreatitis.Dig Dis Sci.1985;30:225-8.
Ohashi K,Kim JH,Hara H,Aso R,Akimoto T,Nakama K.WBN/Kob rats.A new spontaneously occurring model of chronic pancreatitis.Int J Pancreatol.1990;6(4):231-47.
Ohashi S,Nishio A,Nakamura H,et al.Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice.Antioxid Redox Signal.2006;8(9-10):1835-45.doi:10.1089/ars.2006.8.1835.
Okazaki K,Yamamoto Y,Ito K.Endoscopic measurement of papillary sphincter zone and pancreatic main ductal pressure in patients with chronic pancreatitis.Gastroenterology.1986;91:409-18.
Olesen SS,Brock C,Krarup AL,Funch-Jensen P,Arendt-Nielsen L,Wilder-Smith OH,Drewes AM.Descending inhibitory pain modulation is impaired in patients with chronic pancreatitis.Clin Gastroenterol Hepatol.2010a;8:724-30.
Olesen SS,Frøkjær JB,Lelic D,Valeriani M,Drewes AM.Pain-associated adaptive cortical reorganisation in chronic pancreatitis.Pancreatology.2010b;10:742-51.
Olesen SS,Hansen TM,Graversen C,Steimle K,Wilder-Smith OHG,Drewes AM.Slowed EEG rhythmicity in patients with chronic pancreatitis:evidence of abnormal cerebral pain processing?Eur J Gastroenterol Hepatol.2011;23:418-24.
Olesen SS,Graversen C,Bouwense SA,van Goor H,Wilder-Smith OH,Drewes AM.Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis.PLoS One.2013a;8:e57963.
Olesen SS,Hansen TM,Graversen C,Valeriani M,Drewes AM.Cerebral excitability is abnormal in patients with painful chronic pancreatitis.Eur J Pain.2013b;17:46-54.
Pandol SJ,Lugea A,Mareninova OA,et al.Investigating the pathobiology of alcoholic pancreatitis.Alcohol Clin Exp Res.2011;35(5):830-7.doi:10.1111/j.1530-0277.2010.01408.x.
Patel AG,Toyama MT,Alvarez C,Nguyen TN,Reber PU,Ashley SW,Reber HA.Pancreatic interstitial pH in human and feline chronic pancreatitis.Gastroenterology.1995;109:1639-45.
Perides G,Tao X,West N,Sharma A,Steer ML.A mouse model of ethanol dependent pancreatic fibrosis.Gut.2005;54(10):1461-7.doi:10.1136/gut.2004.062919.
Perkins PS,Rutherford RE,Pandol SJ.Effect of chronic ethanol feeding on digestive enzyme synthesis and mRNA content in rat pancreas.Pancreas.1995;10(1):14-21.
Pfutzer RH,Tadic SD,Li HS,et al.Pancreatic cholesterol esterase,ES-10,and fatty acid ethyl ester synthase Ⅲgene expression are increased in the pancreas and liver but not in the brain or heart with long-term ethanol feeding in rats.Pancreas.2002;25(1):101-6.
Pitchumoni CS.Special problems of tropical pancreatitis.Clin Gastroenterol.1984;13(3):941-59.
Pitchumoni CS,Viswanathan KV,Gee Varghese PJ,et al.Ultrastructure and elemental composition of human pancreatic calculi.Pancreas.1987;2:152-8.
Piubello W,Vantini I,Scuro LA,Novelli P,Benini L,Brocco G,Cavallini G.Gastric secretion,gastroduodenal histological changes,and serum gastrin in chronic alcoholic pancreatitis.Am J Gastroenterol.1982;77:105-10.
Prinz RA,Aranha GV,Greenlee HB.Combined pancreatic duct and upper gastrointestinal and biliary tract drainage in chronic pancreatitis.Arch Surg.1985;120:361-6.
Puig-Divi V,Molero X,Salas A,Guarner F,Guarner L,Malagelada JR.Induction of chronic pancreatic disease by trinitrobenzene sulfonic acid infusion into rat pancreatic ducts.Pancreas.1996;13(4):417-24.
Puig-Divi V,Molero X,Vaquero E,Salas A,Guarner F,Malagelada J.Ethanol feeding aggravates morphological and biochemical parameters in experimental chronic pancreatitis.Digestion.1999;60(2):166-74.
Renner IG,Rinderknecht H,Valenzuela JE,et al.Studies of pure pancreatic secretion in chronic alcoholic subjects without pancreatic insufficiency.Scand J Gastroenterol.1980;15:241-4.
Renou C,Grandval P,Ville E,Laugier R.Endoscopic treatment of the main pancreatic duct:correlations among morphology,manometry,and clinical followup.Int J Pancreatol.2000;27:143-9.
Rolny P,Arleback A,Jämerot G,Andersson T.Endoscopic manometry of the sphincter of Oddi and pancreatic duct in chronic pancreatitis.Scand J Gastroenterol.1986;21:415-20.
Sarles H,Bernard JP.Lithostathine and pancreatic lithogenesis.Gastroenterol Int Ed Int.1991;4:130-4.
Sarles H,Lebreuil G,Tasso F,et al.A comparison of alcoholic pancreatitis in rat and man.Gut.1971;12(5):377-88.
Sarnthein J,Stem J,Aufenberg C,Rousson V,Jeanmonod D.Increased EEG power and slowed dominant frequency in patients with neurogenic pain.Brain.2006;129:55-64.
Sato T,Miyashita E,Yamauchi H,Matsuno S.The role of surgical treatment for chronic pancreatitis.Ann Surg.1986;203:266-71.
Saunders JH,Cargill JM,Wormsley KG.Gastric secretion of acid in patients with pancreatic disease.Digestion.1978;17:365-9.
Schneider L,Pietschmann M,Hartwig W,et al.Alcohol pretreatment increases hepatic and pulmonary injury in experimental pancreatitis.Pancreatology.2009;9(3):258-66.doi:10.1159/000181176.
Schulze S,Thorsgaard Pedersen N,Jørgensen MJ,Møllmann KM,Rune SJ.Association between duodenal bulb ulceration and reduced exocrine pancreatic function.Gut.1983;24:781-3.
Schiitte K,Waldthaler A,Malfertheiner P.Klinik der chronischen Pankreatitis.In:Beger HG,Biichler MW,Dralle H,Lerch MM,Malfertheiner P,Mdssner J,Riemann JF,editors.Erkrankungen des Pankreas.Berlin:Springer;2013.p.92-4.
Schwaiger T,van den Brandt C,Fitzner B,et al.Autoinunune pancreatitis in MRL/Mp mice is a T cell-mediated disease responsive to cyclosporine A and rapamycin treatment.Gut.2014;63(3):494-505.doi:10.1136/gutjnl-2012-303635.
Schwartz ES,La JH,Scheff NN,Davis BM,Albers KM,Gebhart GF.TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis.J Neurosci.2013;33:5603-11.
Scoggins CR,Meszoely IM,Wada M,Means AL,Yang L,Leach SD.p53-dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas.Am J Physiol Gastrointest Liver Physiol.2000;279(4):G827-36.
Seleznik GM,Reding T,Romrig F,et al.Lymphotoxin beta receptor signaling promotes development of autoimmune pancreatitis.Gastroenterology.2012;143(5):1361-74.doi:10.1053/j.gastro.2012.07.112.
Sendler M,Dummer A,Weiss FU,et al.Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice.Gut.2013;62(3):430-9.doi:10.1136/gutjnl-2011-30077 1.
Sendler M,Beyer G,Mahajan UM,et al.Complement component 5 mediates development of fibrosis,via activation of stellate cells,in 2 mouse models of chronic pancreatitis.Gastroenterology.2015;149(3):765-76.el0.doi:10.1053/j.gastro.2015.05.012.
Sharer N,Schwarz M,Malone G,et al.Mutations of the cystic fibrosis gene in patients with chronic pancreatitis.N Engl J Med.1998;339(10):645-52.doi:10.1056/NEJM199809033391001.
Snouwaert JN,Brigman KK,Latour AM,et al.An animal model for cystic fibrosis made by gene targeting.Science.1992;257(5073):1083-8.
Steele CW,Karim SA,Foth M,et al.CXCR2 inhibition suppresses acute and chronic pancreatic inflammation.J Pathol.2015;237(1):85-97.doi:10.1002/path.4555.
Steinberg AD,Roths JB,Murphy ED,Steinberg RT,Raveche ES.Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice.J Immunol.1980;125(2):871-3.
Stewart TA.The human reg gene encodes pancreatic stone protein.Biochem J.1989;260:622-3.
Tanaka T,Ichiba Y,Fujii Y,Itoh H,Kodama O,Dohi K.New canine model of chronic pancreatitis due to chronic ischemia with incomplete pancreatic duct obstruction.Digestion.1988;41(3):149-55.
Tanaka T,Miura Y,Matsugu Y,Ichiba Y,Ito H,Dohi K.Pancreatic duct obstruction is an aggravating factor in the canine model of chronic alcoholic pancreatitis.Gastroenterology.1998;115(5):1248-53.
Tatsumi Y,Lichtenberger LM.Molecular association of trinitrobenzenesulfonic acid and surface phospholipids in the development of colitis in rats.Gastroenterology.1996;110(3):780-9.
Toma H,Winston J,Micci MA,Shenoy M,Pasricha PJ.Nerve growth factor expression is up-regulated in the rat model of L-arginine-induced acute pancreatitis.Gastroenterology.2000;119:1373-81.
Treuting PM,Dintzis SM,Liggitt D,Charles W.Pancreas.In:Treuting PM,Dintzis SM,Montine KS,editors.Comparative anatomy and histology:a mouse and human atlas.New York:Elsevier;2012.p.203-9.
Tsujimoto T,Tsuruzono T,Hoppo K,Matsumura Y,Yamao J,Fukui H.Effect of bromhexine hydrochloride therapy for alcoholic chronic pancreatitis.Alcohol Clin Exp Res.2005;29(suppl 12):272S-6S.
Tsukamoto H,Towner SJ,Yu GS,French SW.Potentiation of ethanol-induced pancreatic injury by dietary fat.Induction of chronic pancreatitis by alcohol in rats.Am J Pathol.1988;131(2):246-57.
Tuteja AK,Biskupiak J,Stoddard GJ,Lipman AG.Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic noncancer pain.Neurogastroenterol Motil.2010;22:424-30,e96.
Tuveson DA,Hingorani SR.Ductal pancreatic cancer in humans and mice.Cold Spring Harb Symp Quant Biol.2005;70:65-72.doi:10.1101/sqb.2005.70.040.
Tympner F.Selectively aspirated pure pancreatic secretion.Viscosity,trypsin activity,protein concentration and lactoferrin content of pancreatic juice in chronic pancreatitis.Hepatogastroenterology.1981;28:169-72.
Ugljesi6 M,Bulaji6 M,Milosavljevi6 T,Stimec B.Endoscopic manometry of the sphincter of Oddi and pancreatic duct in patients with chronic pancreatitis.Int J Pancreatol.1996;19:191-5.
Ulmasov B,Oshima K,Rodriguez MG,Cox RD,Neuschwander-Tetri BA.Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis.Am J Pathol.2013;183(3):692-708.doi:10.1016/j.ajpath.2013.05.020.
UnalE,Atalay S,Tolan HK,et al.Biliopancreatic duct injection of ethanol as an experimental model of acute and chronic pancreatitis in rats.Int J Clin Exp Med.2015;8(1):304-10.
Van Laethem JL,Robberecht P,Resibois A,Deviere J.Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice.Gastroenterology.1996;110(2):576-82.
Vaquero E,Molero X,Tian X,Salas A,Malagelada JR.Myofibroblast proliferation,fibrosis,and defective pancreatic repair induced by cyclosporin in rats.Gut.1999;45(2):269-77.
Vaso A,Adahan HM,Gjika A,Zahaj S,Zhurda T,Vyshka G,Devor M.Peripheral nervous system origin of phantom limb pain.Pain.2014;155:1384-91.
Vera-Portocarrero LP,Xie JY,Yie JX,KowalJ,Ossipov MH,King T,Porreca F.Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis.Gastroenterology.2006;130:2155-64.
Vestergaard H,Kruse A,Rokkjaer M,Frobert O,Thommesen P,Funch-Jensen P.Endoscopic manometry of the sphincter of Oddi and the pancreatic and biliary ducts in patients with chronic pancreatitis.Scand J Gastroenterol.1994;29:188-92.
Vijungco JD,Prinz RA.Management of biliary and duodenal complications of chronic pancreatitis.World J Surg.2003;27:1258-70.
Wang RN,Kloppel G,Bouwens L.Duct-to islet-cell differentiation and islet growth in the pancreas of ductligated adult rats.Diabetologia.1995;38(12):1405-11.
Wang Y,Wrennall JA,Cai Z,Li H,Sheppard DN.Understanding how cystic fibrosis mutations disrupt CFTR function:from single molecules to animal models.Int J Biochem Cell Biol.2014;52:47-57.doi:10.1016/j.biocel.2014.04.001.
Warshaw AL,Banks PA,Fernández-Del Castillo C.AGA technical review:treatment of pain in chronic pancreatitis.Gastroenterology.1998;115:765-76.
Watanabe S,Abe K,Anbo Y,Katoh H.Changes in the mouse exocrine pancreas after pancreatic duct ligation:a qualitative and quantitative histological study.Arch Histol Cytol.1995;58(3):365-74.
Watkins-Chow DE,Pavan WJ.Genomic copy number and expression variation within the C57BL/6J inbred mouse strain.Genome Res.2008;18(1):60-6.doi:10.1101/gr.6927808.
Weiss FU,Simon P,Bogdanova N,et al.Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls.Gut.2005;54(10):1456-60.doi:10.1136/gut.2005.064808.
Weiss FU,Schurmann C,Guenther A,et al.Fucosyltransferase 2(FUT2)non-secretor status and bloodgroup B are associated with elevated serum lipase activity in asymptomatic subjects,and an increased risk for chronic pancreatitis:a genetic association study.Gut.2015;64(4):646-56.doi:10.1136/gutjnl-2014-306930.
Whitcomb DC.Genetics of alcoholic and nonalcoholic pancreatitis.Curr Opin Gastroenterol.2012;28(5):501-6.doi:10.1097/MOG.0b013e328356e7f3.
Whitcomb DC,Gorry MC,Preston RA,et al.Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene.Nat Genet.1996;14(2):141-5.doi:10.1038/ng1096-141.
Whitcomb DC,LaRusch J,Krasinskas AM,et al.Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.Nat Genet.2012;44(12):1349-54.doi:10.1038/ng.2466.
White TT,Bourde J.A new observation on human intraductal pancreatic pressure.Surg Gynecol Obstet.1970;130:275-8.
Wilcox CM,Yadav D,Ye T,et al.Chronic pancreatitis pain pattern and severity are independent of abdominal imaging findings.Clin Gastroenterol Hepatol.2015;13:552-60,quiz e28-9.
Willert RP,Woolf CJ,Hobson AR,Delaney C,Thompson DG,Aziz Q.The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor.Gastroenterology.2004;126:683-92.
Wolf MJ,Seleznik GM,Zeller N,Heikenwalder M.The unexpected role of lymphotoxin beta receptor signaling in carcinogenesis:from lymphoid tissue formation to liver and prostate cancer development.Oncogene.2010;29(36):5006-18.doi:10.1038/onc.2010.260.
Wong GY,Gavva NR.Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics:recent advances and setbacks.Brain Res Rev.2009;60:267-77.
Woodruff TM,Nandakumar KS,Tedesco F.Inhibiting the C5-C5areceptoraxis.MolImmunol.2011;48(14):1631-42.doi:10.1016/j.molimm.2011.04.014.
Woolf CJ.Central sensitization:implications for the diagnosis and treatment of pain.Pain.2011;152:52-15.
Woolf CJ,Salter MW.Neuronal plasticity:increasing the gain in pain.Science.2000;288:1765-9.
Woolf CJ,Safieh-Garabedian B,Ma QP,Crilly P,Winter J.Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity.Neuroscience.1994;62:327-31.
Xu G-Y,Winston JH,Shenoy M,Yin H,Pendyala S,Pasricha PJ.Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis.Gastroenterology.2007;133:1282-92.
Yadav D,Lowenfels AB.The epidemiology of pancreatitis and pancreatic cancer.Gastroenterology.2013;144(6):1252-61.doi:10.1053/j.gastro.2013.01.068.
Yadav D,Timmons L,Benson JT,Dierkhising RA,Chari ST.Incidence,prevalence,and survival of chronic pancreatitis:a population-based study.Am J Gastroenterol.2011;106(12):2192-9.doi:10.1038/ajg.2011.328.
Yadav D,O'Connell M,Papachristou GI.Natural history following the first attack of acute pancreatitis.Am J Gastroenterol.2012;107(7):1096-103.doi:10.1038/ajg.2012.126.
Yamamoto M,Otani M,Otsuki M.A new model of chronic pancreatitis in rats.Am J Physiol Gastrointest Liver Physiol.2006;291(4):G700-8.doi:10.1152/ajpgi.00502.2005.
Yarnitsky D,Granot M,Nahman-Averbuch H,Khamaisi M,Granovsky Y.Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy.Pain.2012;153:1193-8.
Zambreanu L,Wise RG,Brooks JCW,Iannetti GD,Tracey I.A role for the brainstem in central sensitisation in humans.Evidence from functional magnetic resonance imaging.Pain.2005;114:397-407.
Zhao HF,Ito T,Gibo J,et al.Anti-monocyte chemoattractant protein 1 gene therapy attenuates experimental chronic pancreatitis induced by dibutyltin dichloride in rats.Gut.2005;54(12):1759-67.doi:10.1136/gut.2004.049403.
Zhu Y,Colak T,Shenoy M,Liu L,Pai R,Li C,Mehta K,Pasricha PJ.Nerve growth factor modulates TRPV1 expression and function and mediates pain in chronic pancreatitis.Gastroenterology.2011;141:370-7.