3.2 Identification of a Risk SNP in the CLDN2 Locus
The GWAS study also identified a SNP in the X-linked and pancreas-expressed CLDN2（claudin-2；OMIM#300520）locus that appeared to be significantly associated with chronic pancreatitis（Whitcomb et al.2012）.Supporting data were obtained from multiple replication studies（Avanthi et al.2015；Derikx et al.2015；Giri et al.2016；Masamune et al.2015；Paliwal et al.2016）.The CLDN2 risk allele was reported to be associated with the atypical localization of CLDN2 in pancreatic acinar cells，but whether this allele is the causal variant underlying the chronic pancreatitis or simply a linkage disequilibrium marker remains to be clarified.(https://www.daowen.com)
