1.7　Other Organ Involvement（OOI）

It has been increasingly recognized that type 1 AIP is a pancreatic manifestation of systemic IgG4-related disease（Umehara et al.2012；Kamisawa et al.2015）.Extra-pancreatic involvements include IgG4-related sclerosing cholangitis（Fig.11.3a），retroperitoneal fibrosis，dacryoadenitis/sialadenitis（Fig.11.3b），and interstitial nephritis.Type 2 AIP is frequently accompanied by inflammatory bowel diseases in about 30%of cases（Kamisawa et al.2013；Hart et al.2015a；Okazaki and Uchida 2015）.18F-fluorodeoxyglucose positron emission tomography is useful for detecting extrapancreatic lesions as well as pancreatic ones（Fig.11.3c）.(https://www.daowen.com)