2.5　Future Directions

Aforementioned observations suggest that there are multiple factors that can alter the phenotype of a complex disease as exemplified by TCP.However，we have not been able to translate these understandings to individual patient care.It is thus emphasized that genotype-phenotype correlation needs to be investigated thoroughly further to track the changes in disease presentation with underlying genetic susceptibility when exposed to certain environmental risk factors.(https://www.daowen.com)

Acknowledgements We express our sincere gratitude to the patients and normal subjects who agreed to participate in our study.The support of Dr.D Nageshwar Reddy and Dr.G V Rao from Asian Institute of Gastroenterology，Hyderabad，India in generating a case-control cohort is greatly acknowledged.We also appreciate the efforts of our other collaborators Dr.S P Singh，Cuttack Medical College，Cuttack，India and Dr.Varghese Thomas，Calicut Medical College，Calicut，India in recruiting individuals and providing biological samples.We also thank Council of Scientific and Industrial Research，Indian Council of Medical Research，and Department of Biotechnology，Ministry of Science and technology，Government of India，India for financial assistance.