Breast (C50)
In 2016, breast cancer cases accounted for 7.80% of all cancer cases in Henan cancer registration areas with the crude incidence of 43.20/105, ASR for China 35.08/105 and ASR for World 32.88/105.The crude incidence in urban areas was 49.62/105, and 41.50/105 in rural areas.It was 1.10 times in urban areas as that in rural areas.The crude mortality rate of breast cancer in 2016 was 11.74/105, ASR for China was 8.92/105 and ASR for World 8.76/105.The cumulative rates of incidence and mortality from 0 to 74 years old were 3.49% and 1.00%, respectively.(Table 5-12)
表5-12 河南省肿瘤登记地区乳房恶性肿瘤发病与死亡
乳房恶性肿瘤年龄别发病率和死亡率在0~19 岁年龄段处于较低水平，20 岁以后快速上升，在45 岁和85 岁组达到高峰。城乡和不同地区年龄别率的水平虽然有一定的差异，但总体趋势类同。（图5-12a ～图5-12b）
图5-12a 河南省肿瘤登记地区乳房恶性肿瘤年龄别发病率，2016
在8 个城市肿瘤登记地区中，发病率最高的是濮阳市华龙区（63.59/10 万），其次是洛阳市和漯河市。死亡率最高的是漯河市（23.46/10万）。（图5-12c）
The age-specific incidence and mortality rates of breast cancer were relatively low before 20 years old and increased dramatically since 20 years old, reaching the peak at the age group of 45 and 85,respectively.The age-specific incidence and mortality rates varied in urban and rural areas with similar curves.(Figure 5-12a~figure 5-12b).
图5-12b 河南省肿瘤登记地区乳房恶性肿瘤年龄别死亡率，2016
Among the 8 urban cancer registration areas, the ASR China incidence rate of breast cancer in female was the highest in Hualong District of Puyang City(63.59/105), followed by Luoyang City and Luohe City.The highest age-specific mortality was in Luohe City(23.46/105) for females.(Figure 5-12c)
图5-12c 城市肿瘤登记地区乳房恶性肿瘤发病率与死亡率(https://www.daowen.com)
在27 个农村肿瘤登记地区中，发病率最高的是商丘市虞城县（55.90/10 万），其次是商丘市睢县和巩义市。死亡率最高的是周口市郸城县（21.79/10 万）。（图5-12d）
Among the 27 rural cancer registration areas, the ASR China incidence rate of breast cancer in female was the highest in Yucheng County of Shangqiu(55.90/105), followed by Sui County of Shangqiu City and Gongyi City.The highest age-specific mortality of breast cancer was in Dancheng County of Zhoukou City (21.79/105).(Figure 5-12d)
图5-12d 农村肿瘤登记地区乳房恶性肿瘤发病率与死亡率
2016 年肿瘤登记地区女性乳腺癌发病病例中有确切解剖学亚部位（C50.0-C50.6，C50.8）信息的占37.4%，亚部位未特指（C50.9）的占62.6%。在有亚部位的乳腺癌病例中，发生在乳腺乳头和乳晕区（C50.0）的占7.7%，乳腺中央部（C50.1）的占17.5%，乳腺上内象限（C50.2）的占23.6%，乳腺下内象限（C50.3）的占7.6%，乳腺上外象限（C50.4）的占34.5%，乳腺下外象限（C50.5）的占4.8%，乳腺腋尾部（C50.6）的占2.0%，乳腺交搭跨越（C50.8）的占2.4%。（图5-12e）
Among all the reported breast cancer cases in 2016, 37.4% had specified subcategories(C50.0-C50.6, C50.8) and the rest 62.6% had unspecified subcategory (C50.9).The specified subcategories of breast cancer included nipple and areola (C50.0) (7.7%), central portion (C50.1)(17.5%), upper inner (C50.2) (23.6%), lower inner(C50.3) (7.6%), upper outer (C50.4) (34.5%), lower outer (C50.5) (4.8%) and axillary tail (C50.6) (2.0%)and overlapping parts (C50.8) (2.4%).(Figure 5-12e)
图5-12e 河南省女性乳腺癌发病亚部位构成（%）
2016 年肿瘤登记地区女性乳腺癌发病病例中有明确组织病理学分型的占78.1%，组织学类型未特指的占21.9%。在有组织病理学分型的乳腺癌病例中，导管内癌占75.9%，小叶癌占4.2%，髓样癌占0.5%，佩吉特病占0.3%，其他类型的乳腺癌占19.0%。（图5-12f）
Among all cases, 78.1% had specific pathological diagnostic information and the rest 21.9% had unspecified pathological types.Ductal carcinoma accounted for 75.9% of the cases with specific pathological diagnostic information, lobular carcinoma accounted for 4.2 %, medullary carcinoma 0.5%, Paget's 0.3% and other histological breast type 19.0%.(Figure 5-12f)
图5-12f 河南省女性乳腺癌发病形态学构成（%）