2009—2019年研究所发表英文论文题录

十一、2009—2019年研究所发表英文论文题录

1.Bai DS,Dai Z,Zhou J,Liu YK,Qiu SJ,Tan CJ,Shi YH,Huang C,Wang Z,He YF,Fan J.Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma.Hepatology,2009,49:460-470.

2.Cai MY,Xu YF,Qiu SJ,Ju MJ,Gao Q,Li YW,Zhang BH,Zhou J,Fan J.Human leukocyte antigen-G protein expression is an unfavorable prognostic predictor of hepatocellular carcinoma following curative resection.Clin Cancer Res,2009,15:4686-4693.

3.Cao J,Shen C,Wang H,Shen H,Chen Y,Nie A,Yan G,Lu H,Liu Y,Yang P.Identification of N-glycosylation sites on secreted proteins of human hepatocellular carcinoma cells with a complementary proteomics approach.J Proteome Res,2009,8:662-672.

4.Dai CX,Gao Q,Qiu SJ,Ju MJ,Cai MY,Xu YF,Zhou J,Zhang BH,Fan J.Hypoxiainducible factor-1 alpha,in association with inflammation,angiogenesis and MYC,is a critical prognostic factor in patients with HCC after surgery.BMC Cancer,2009,9:418.

5.Dai Z,Yu L,Zhou J,Qiu SJ,Fan J.Molecular markers and hepatocellular carcinoma:lending a helping hand in liver transplantation?Expert Rev Gastroenterol Hepatol,2009,3:211-213.

6.Dai Z,Zhou J,Qiu SJ,Liu YK,Fan J.Lectin-based glycoproteomics to explore and analyze hepatocellular carcinoma-related glycoprotein markers.Electrophoresis,2009,30:2957-2966.

7.Ding ZB,Shi YH,Zhou J,Shi GM,Ke AW,Qiu SJ,Wang XY,Dai Z,Xu Y,Fan J.Liverintestine cadherin predicts microvascular invasion and poor prognosis of hepatitis B viruspositive hepatocellular carcinoma.Cancer,2009,115:4753-4765.

8.Fan HZ,Liu H,Zhang C,Gao DM,Xue Q,Chen J,Sun RX,Liu YK,Yang PY.Comparative proteomics and molecular mechanical analysis in CDA-II induced therapy of LCID20 hepatocellular carcinoma model.J Cancer Res Clin Oncol,2009,135:591-602.

9.Fan J,Yang GS,Fu ZR,Peng ZH,Xia Q,Peng CH,Qian JM,Zhou J,Xu Y,Qiu SJ,Zhong L,Zhou GW,Zhang JJ.Liver transplantation outcomes in 1,078 hepatocellular carcinoma patients:a multi-center experience in Shanghai,China.J Cancer Res Clin Oncol,2009,135:1403-1412.

10.Fu LY,Jia HL,Dong QZ,Wu JC,Zhao Y,Zhou HJ,Ren N,Ye QH,Qin LX.Suitable reference genes for real-time PCR in human HBV-related hepatocellular carcinoma with different clinical prognoses.BMC Cancer,2009,9:49.

11.Gao Q,Wang XY,Qiu SJ,Yamato I,Sho M,Nakajima Y,Zhou J,Li BZ,Shi YH,Xiao YS,Xu Y,Fan J.Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma.Clin Cancer Res,2009,15:971-979.

12.Guo K,Kang NX,Li Y,Sun L,Gan L,Cui FJ,Gao MD,Liu KY.Regulation of HSP27 on NF-kappaB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis.BMC Cancer,2009,9:100.

13.Guo K,Li Y,Kang X,Sun L,Cui J,Gao D,Liu Y.Role of PKCbeta in hepatocellular carcinoma cells migration and invasion in vitro:a potential therapeutic target.Clin Exp Metastasis,2009,26:189-195.

14.Hu J,Xu Y,Shen ZZ,Wang Z,Lu Q,Yang GH,Ding ZB,Fan J,Zhou J.High expressions of vascular endothelial growth factor and platelet-derived endothelial cell growth factor predict poor prognosis in alpha-fetoprotein-negative hepatocellular carcinoma patients after curative resection.J Cancer Res Clin Oncol,2009,135:1359-1367.

15.Huang XY,Wang L,Huang ZL,Zheng Q,Li QS,Tang ZY.Herbal extract“Songyou Yin” inhibits tumor growth and prolongs survival in nude mice bearing human hepatocellular carcinoma xenograft with high metastatic potential.J Cancer Res Clin Oncol,2009,135:1245-1255.

16.Ji J,Shi J,Budhu A,Yu Z,Forgues M,Roessler S,Ambs S,Chen Y,Meltzer PS,Croce CM,Qin LX,Man K,Lo CM,Lee J,Ng IO,Fan J,Tang ZY,Sun HC,Wang XW.MicroRNA expression,survival,and response to interferon in liver cancer.N Engl J Med,2009,361:1437-1447.

17.Ju MJ,Qiu SJ,Fan J,Xiao YS,Gao Q,Zhou J,Li YW,Tang ZY.Peritumoral activated hepatic stellate cells predict poor clinical outcome in hepatocellular carcinoma after curative resection.Am J Clin Pathol,2009,131:498-510.

18.Ju MJ,Qiu SJ,Fan J,Zhou J,Gao Q,Cai MY,Li YW,Tang ZY.Preoperative serum gamma-glutamyl transferase to alanine aminotransferase ratio is a convenient prognostic marker for Child-Pugh A hepatocellular carcinoma after operation.J Gastroenterol,2009,44:635-642.

19.Ju MJ,Qiu SJ,Gao Q,Fan J,Cai MY,Li YW,Tang ZY.Combination of peritumoral mast cells and T-regulatory cells predicts prognosis of hepatocellular carcinoma.Cancer Sci,2009,100:1267-1274.

20.Ke AW,Shi GM,Zhou J,Wu FZ,Ding ZB,Hu MY,Xu Y,Song ZJ,Wang ZJ,Wu JC,Bai DS,Li JC,Liu KD,Fan J.Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma.Hepatology,2009,49:491-503.

21.Li H,Ren Z,Kang X,Zhang L,Li X,Wang Y,Xue T,Shen Y,Liu Y.Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells.BMC Cancer,2009,9:366.

22.Li Y,Kang X,Guo K,Li X,Gao D,Cui J,Sun L,Yang P,Liu Y.Proteome alteration of early-stage differentiation of mouse embryonic stem cells into hepatocyte-like cells.Electrophoresis,2009,30:1431-1440.

23.Li YW,Qiu SJ,Fan J,Gao Q,Zhou J,Xiao YS,Xu Y,Wang XY,Sun J,Huang XW.Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection.J Cancer Res Clin Oncol,2009,135:439-449.

24.Ni HM,Chen X,Shi YH,Liao Y,Beg AA,Fan J,Yin XM.Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice.J Biol Chem,2009,284:4373-4382.

25.Shi YH,Ding ZB,Zhou J,Qiu SJ,Fan J.Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma.Autophagy,2009,5:380-382.

26.Shi YH,Zhou J,Fan J.Treatment for the recurrence of hepatocellular carcinoma following liver transplantation:what is the best strategy?Cancer Biol Ther,2009,8:22-24.

27.Sun Q,Kang X,Zhang Y,Zhou H,Dai Z,Lu W,Zhou X,Liu X,Yang P,Liu Y.DSA affinity glycoproteome of human liver tissue.Arch Biochem Biophys,2009,484:24-29.

28.Xiong YQ,Sun HC,Zhang W,Zhu XD,Zhuang PY,Zhang JB,Wang L,Wu WZ,Qin LX,Tang ZY.Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells.Clin Cancer Res,2009,15:4838-4846.

29.Yang XR,Xu Y,Yu B,Zhou J,Li JC,Qiu SJ,Shi YH,Wang XY,Dai Z,Shi GM,Wu B,Wu LM,Yang GH,Zhang BH,Qin WX,Fan J.CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery.Clin Cancer Res,2009,15:5518-5527.

30.Yu B,Yang X,Xu Y,Yao G,Shu H,Lin B,Hood L,Wang H,Yang S,Gu J,Fan J,Qin W.Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas.J Hepatol,2009,50:948-957.

31.Zhang N,Wang L,Liang Y,Zhao YM,Xue Q,Wu WZ,Sun HC,Fan J,Tang ZY.The antiangiogenic effects of tyroservatide on animal models of hepatocellular carcinoma.J Cancer Res Clin Oncol,2009,135:1447-1453.

32.Zhou XD,Tang ZY,Fan J,Zhou J,Wu ZQ,Qin LX,Ma ZC,Sun HC,Qiu SJ,Yu Y,Ren N,Ye QH,Wang L,Ye SL.Intrahepatic cholangiocarcinoma:report of 272 patients compared with 5,829 patients with hepatocellular carcinoma.J Cancer Res Clin Oncol,2009,135:1073-1080.

33.Zhou XD,Tang ZY,Ma ZC,Fan J,Wu ZQ,Qin LX,Zhou J,Yu Y,Sun HC,Qiu SJ.Twenty-year survivors after resection for hepatocellular carcinoma-analysis of 53 cases.J Cancer Res Clin Oncol,2009,135:1067-1072.

34.Chen RX,Xia YH,Cui JF,Xue TC,Ye SL.Osteopontin,a single marker for predicting the prognosis of patients with tumor-node-metastasis stage I hepatocellular carcinoma after surgical resection.J Gastroenterol Hepatol,2010,25:1435-1442.

35.Chen RX,Xia YH,Xue TC,Ye SL.Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression.J Exp Clin Cancer Res,2010,29:172.

36.Gan L,Guo K,Li Y,Kang X,Sun L,Shu H,Liu Y.Up-regulated expression of stathmin may be associated with hepatocarcinogenesis.Oncol Rep,2010,23:1037-1043.

37.Huang H,Zhang XF,Zhou HJ,Xue YH,Dong QZ,Ye QH,Qin LX.Expression and prognostic significance of osteopontin and caspase-3 in hepatocellular carcinoma patients after curative resection.Cancer Sci,2010,101:1314-1319.

38.Huang XY,Huang ZL,Wang L,Xu YH,Huang XY,Ai KX,Zheng Q,Tang ZY.Herbal compound“Songyou Yin”reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice.BMC Cancer,2010,10:580.

39.Huang XY,Ke AW,Shi GM,Ding ZB,Devbhandari RP,Gu FM,Li QL,Dai Z,Zhou J,Fan J.Overexpression of CD151 as an adverse marker for intrahepatic cholangiocarcinoma patients.Cancer,2010,116:5440-5451.

40.Jia JB,Wang WQ,Sun HC,Zhu XD,Liu L,Zhuang PY,Zhang JB,Zhang W,Xu HX,Kong LQ,Lu L,Wu WZ,Wang L,Tang ZY.High expression of macrophage colony-stimulating factor-1 receptor in peritumoral liver tissue is associated with poor outcome in hepatocellular carcinoma after curative resection.Oncologist,2010,15:732-743.

41.Kang X,Sun L,Guo K,Shu H,Yao J,Qin X,Liu Y.Serum protein biomarkers screening in HCC patients with liver cirrhosis by ICAT-LC-MS/MS.J Cancer Res Clin Oncol,2010,136:1151-1159.

42.Li GC,Ye QH,Xue YH,Sun HJ,Zhou HJ,Ren N,Jia HL,Shi J,Wu JC,Dai C,Dong QZ,Qin LX.Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97-H cell line.Cancer Sci,2010,101:2546-2553.

43.Li JC,Yang XR,Sun HX,Xu Y,Zhou J,Qiu SJ,Ke AW,Cui YH,Wang ZJ,Wang WM,Liu KD,Fan J.Up-regulation of Kruppel-like factor 8 promotes tumor invasion and indicates poor prognosis for hepatocellular carcinoma.Gastroenterology,2010,139:2146-2157,e2112.

44.Li X,Li Y,Kang X,Guo K,Li H,Gao D,Sun L,Liu Y.Dynamic alteration of protein expression profiles during neoplastic transformation of rat hepatic oval-like cells.Cancer Sci,2010,101:1099-1107.

45.Liu BB,Zheng D,Liu YK,Kang XN,Sun L,Guo K,Sun RX,Chen J,Zhao Y.Array-based profiling of the differential methylation status of Cp G islands in hepatocellular carcinoma cell lines.Oncol Lett,2010,1:815-820.

46.Liu L,Ren ZG,Shen Y,Zhu XD,Zhang W,Xiong W,Qin Y,Tang ZY.Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model:relevance of epithelial-mesenchymal transition.Cancer Sci,2010,101:120-128.

47.Liu L,Zhu XD,Wang WQ,Shen Y,Qin Y,Ren ZG,Sun HC,Tang ZY.Activation of betacatenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis.Clin Cancer Res,2010,16:2740-2750.

48.Shi GM,Ke AW,Zhou J,Wang XY,Xu Y,Ding ZB,Devbhandari RP,Huang XY,Qiu SJ,Shi YH,Dai Z,Yang XR,Yang GH,Fan J.CD151 modulates expression of matrix metalloproteinase 9 and promotes neoangiogenesis and progression of hepatocellular carcinoma.Hepatology,2010,52:183-196.

49.Shu H,Kang X,Guo K,Li S,Li M,Sun L,Gan L,Liu Y,Qin X.Diagnostic value of serum haptoglobin protein as hepatocellular carcinoma candidate marker complementary to alpha fetoprotein.Oncol Rep,2010,24:1271-1276.

50.Sun J,Xu HM,Zhou HJ,Dong QZ,Zhao Y,Fu LY,Hei ZY,Ye QH,Ren N,Jia HL,Qin LX.The prognostic significance of preoperative plasma levels of osteopontin in patients with TNM stage-I of hepatocellular carcinoma.J Cancer Res Clin Oncol,2010,136:1-7.

51.Wang KF,Ye SL,Song LJ,Weng YQ.The metastasis of hepatocarcinoma can be inhibited by T lymphocytes reconstitution in nude mice model.Hepatogastroenterology,2010,57:1220-1226.

52.Wu JC,Sun BS,Ren N,Ye QH,Qin LX.Genomic aberrations in hepatocellular carcinoma related to osteopontin expression detected by array-CGH.J Cancer Res Clin Oncol,2010,136:595-601.

53.Xia Y,Chen R,Song Z,Ye S,Sun R,Xue Q,Zhang Z.Gene expression profiles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum.J Cancer Res Clin Oncol,2010,136:309-321.

54.Xiong W,Ren ZG,Qiu SJ,Sun HC,Wang L,Liu BB,Li QS,Zhang W,Zhu XD,Liu L,Wang WQ,Tang ZY.Residual hepatocellular carcinoma after oxaliplatin treatment has increased metastatic potential in a nude mouse model and is attenuated by Songyou Yin.BMC Cancer,2010,10:219.

55.Xu M,Tan C,Zhou J,Huang X,Dai Z,Zhu H,Zhao Y,Gu F,Zhou S,Fan J.The dynamic changes of T-bet(+)/GATA-3(+)and RORgammat(+)/FOXP3(+)cells in recipient spleens and grafts after rat orthotopic liver transplantation.Transpl Immunol,2010,22:165-171.

56.Xu YF,Yi Y,Qiu SJ,Gao Q,Li YW,Dai CX,Cai MY,Ju MJ,Zhou J,Zhang BH,Fan J.PEBP1 downregulation is associated to poor prognosis in HCC related to hepatitis B infection.J Hepatol,2010,53:872-879.

57.Xue YH,Zhang XF,Dong QZ,Sun J,Dai C,Zhou HJ,Ren N,Jia HL,Ye QH,Qin LX.Thrombin is a therapeutic target for metastatic osteopontin-positive hepatocellular carcinoma.Hepatology,2010,52:2012-2022.

58.Yang XR,Xu Y,Yu B,Zhou J,Qiu SJ,Shi GM,Zhang BH,Wu WZ,Shi YH,Wu B,Yang GH,Ji Y,Fan J.High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma.Gut,2010,59:953-962.

59.Ye SL,Takayama T,Geschwind J,Marrero JA,Bronowicki JP.Current approaches to the treatment of early hepatocellular carcinoma.Oncologist,2010,15(Suppl 4):34-41.

60.Zhang T,Sun HC,Zhou HY,Luo JT,Zhang BL,Wang P,Wang L,Qin LX,Ren N,Ye SL,Li Q,Tang ZY.Interferon alpha inhibits hepatocellular carcinoma growth through inducing apoptosis and interfering with adhesion of tumor endothelial cells.Cancer Lett,2010,290:204-210.

61.Zhang W,Zhu XD,Sun HC,Xiong YQ,Zhuang PY,Xu HX,Kong LQ,Wang L,Wu WZ,Tang ZY.Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects.Clin Cancer Res,2010,16:3420-3430.

62.Zhou H,Huang H,Shi J,Zhao Y,Dong Q,Jia H,Liu Y,Ye Q,Sun H,Zhu X,Fu L,Guo K,Gao D,Sun J,Yan Z,Ren N,Tang Z,Qin L.Prognostic value of interleukin 2 and interleukin 15 in peritumoral hepatic tissues for patients with hepatitis B-related hepatocellular carcinoma after curative resection.Gut,2010,59:1699-1708.

63.Zhou J,Shen Z,He Y,Zheng S,Fan J.The current status of pediatric liver transplantation in Mainland China.Pediatr Transplant,2010,14:575-582.

64.Zhou J,Wang Z,Qiu SJ,Huang XW,Sun J,Gu W,Fan J.Surgical treatment for early hepatocellular carcinoma:comparison of resection and liver transplantation.J Cancer Res Clin Oncol,2010,136:1453-1460.

65.Zhuang PY,Zhang JB,Zhang W,Zhu XD,Liang Y,Xu HX,Xiong YQ,Kong LQ,Wang L,Wu WZ,Tang ZY,Qin LX,Sun HC.Long-term interferon-alpha treatment suppresses tumor growth but promotes metastasis capacity in hepatocellular carcinoma.J Cancer Res Clin Oncol,2010,136:1891-1900.

66.Chen XH,Zhang BH,Xin Y,Ren ZG,Fan J,Qiu SJ,Zhou J.Risk factors for residual tumor after resection of hepatocellular carcinoma.World J Gastroenterol,2011,17:1889-1894.

67.Cheng JW,Shi YH,Fan J,Huang XW,Qiu SJ,Xiao YS,Wang Z,Dai Z,Tang ZY,Zhou J.An immune function assay predicts post-transplant recurrence in patients with hepatocellular carcinoma.J Cancer Res Clin Oncol,2011,137:1445-1453.

68.Dai C,Dong QZ,Ren N,Zhu JJ,Zhou HJ,Sun HJ,Wang G,Zhang XF,Xue YH,Jia HL,Ye QH,Qin LX.Downregulation of HTPAP transcript variant 1 correlates with tumor metastasis and poor survival in patients with hepatocellular carcinoma.Cancer Sci,2011,102:583-590.

69.Devbhandari RP,Shi GM,Ke AW,Wu FZ,Huang XY,Wang XY,Shi YH,Ding ZB,Xu Y,Dai Z,Fan J,Zhou J.Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin beta1 complex in the progression of hepatocellular carcinoma.PLoS One,2011,6:e24901.

70.Ding ZB,Hui B,Shi YH,Zhou J,Peng YF,Gu CY,Yang H,Shi GM,Ke AW,Wang XY,Song K,Dai Z,Shen YH,Fan J.Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation.Clin Cancer Res,2011,17:6229-6238.

71.Gao Q,Wang XY,Qiu SJ,Zhou J,Shi YH,Zhang BH,Fan J.Tumor stroma reaction-related gene signature predicts clinical outcome in human hepatocellular carcinoma.Cancer Sci,2011,102:1522-1531.

72.Gao Q,Wang XY,Zhou J,Fan J.Cell line misidentification:the case of the Chang liver cell line.Hepatology,2011,54:1894-1895.

73.Gu FM,Li QL,Gao Q,Jiang JH,Huang XY,Pan JF,Fan J,Zhou J.Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3.World J Gastroenterol,2011,17:3922-3932.

74.Gu FM,Li QL,Gao Q,Jiang JH,Zhu K,Huang XY,Pan JF,Yan J,Hu JH,Wang Z,Dai Z,Fan J,Zhou J.IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma.Mol Cancer,2011,10:150.

75.Hu J,Wang Z,Fan J,Dai Z,He YF,Qiu SJ,Huang XW,Sun J,Xiao YS,Song K,Shi YH,Sun QM,Yang XR,Shi GM,Yu L,Yang GH,Ding ZB,Gao Q,Tang ZY,Zhou J.Genetic variations in plasma circulating DNA of HBV-related hepatocellular carcinoma patients predict recurrence after liver transplantation.PLoS One,2011,6:e26003.

76.Jia JB,Wang WQ,Sun HC,Liu L,Zhu XD,Kong LQ,Chai ZT,Zhang W,Zhang JB,Xu HX,Zeng ZC,Wu WZ,Wang L,Tang ZY.A novel tripeptide,tyroserleutide,inhibits irradiation-induced invasiveness and metastasis of hepatocellular carcinoma in nude mice.Invest New Drugs,2011,29:861-872.

77.Jin GZ,Li Y,Cong WM,Yu H,Dong H,Shu H,Liu XH,Yan GQ,Zhang L,Zhang Y,Kang XN,Guo K,Wang ZD,Yang PY,Liu YK.i TRAQ-2DLC-ESI-MS/MS based identification of a new set of immunohistochemical biomarkers for classification of dysplastic nodules and small hepatocellular carcinoma.J Proteome Res,2011,10:3418-3428.

78.Ke AW,Shi GM,Zhou J,Huang XY,Shi YH,Ding ZB,Wang XY,Devbhandari RP,Fan J.CD151 amplifies signaling by integrin alpha6beta1 to PI3K and induces the epithelialmesenchymal transition in HCC cells.Gastroenterology,2011,140:1629-1641,e1615.

79.Li T,Zeng ZC,Wang L,Qiu SJ,Zhou JW,Zhi XT,Yu H H,Tang ZY.Radiation enhances long-term metastasis potential of residual hepatocellular carcinoma in nude mice through TMPRSS4-induced epithelial-mesenchymal transition.Cancer Gene Ther,2011,18:617-626.

80.Li YW,Qiu SJ,Fan J,Zhou J,Gao Q,Xiao YS,Xu YF.Intratumoral neutrophils:a poor prognostic factor for hepatocellular carcinoma following resection.J Hepatol,2011,54:497-505.

81.Ren N,Wu JC,Dong QZ,Sun HJ,Jia HL,Li GC,Sun BS,Dai C,Shi J,Wei JW,Sheng YY,Zhou HJ,Ye QH,Qin LX.Association of specific genotypes in metastatic suppressor HTPAP with tumor metastasis and clinical prognosis in hepatocellular carcinoma.Cancer Res,2011,71:3278-3286.

82.Shi YH,Ding ZB,Zhou J,Hui B,Shi GM,Ke AW,Wang XY,Dai Z,Peng YF,Gu CY,Qiu SJ,Fan J.Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis.Autophagy,2011,7:1159-1172.

83.Shu H,Zhang S,Kang X,Li S,Qin X,Sun C,Lu H,Liu Y.Protein expression and fucosylated glycans of the serum haptoglobin-{beta}subunit in hepatitis B virus-based liver diseases.Acta Biochim Biophys Sin(Shanghai),2011,43:528-534.

84.Sun C,Liu YK.Induced pluripotent cancer cells:progress and application.J Cancer Res Clin Oncol,2011,137:1-8.

85.Tang J,Cui J,Chen R,Guo K,Kang X,Li Y,Gao D,Sun L,Xu C,Chen J,Tang Z,Liu Y.A three-dimensional cell biology model of human hepatocellular carcinoma in vitro.Tumour Biol,2011,32:469-479.

86.Wang C,Guo K,Gao D,Kang X,Jiang K,Li Y,Sun L,Zhang S,Sun C,Liu X,Wu W,Yang P,Liu Y.Identification of transaldolase as a novel serum biomarker for hepatocellular carcinoma metastasis using xenografted mouse model and clinic samples.Cancer Lett,2011,313:154-166.

87.Wang DD,Zhao YM,Wang L,Ren G,Wang F,Xia ZG,Wang XL,Zhang T,Pan Q,Dai Z,Chen JP,Dai HY,Zhang W,He HW,Zhou JM,Tang GY,Zhou J,Fan J,Tang ZY.Preoperative serum retinol-binding protein 4 is associated with the prognosis of patients with hepatocellular carcinoma after curative resection.J Cancer Res Clin Oncol,2011,137:651-658.

88.Wang WM,Xu Y,Yang XR,Wang YH,Sun HX,Fan J.Prognostic role of diabetes mellitus in hepatocellular carcinoma patients after curative treatments:a meta-analysis.Hepatobiliary Pancreat Dis Int,2011,10:346-355.

89.Wang Z,Hu J,Qiu SJ,Huang XW,Dai Z,Tan CJ,Zhou J,Fan J.An investigation of the effect of sorafenib on tumour growth and recurrence after liver cancer resection in nude mice independent of phosphorylated extracellular signal-regulated kinase levels.Expert Opin Investig Drugs,2011,20:1039-1045.

90.Xiong YQ,Sun HC,Zhu XD,Zhang W,Zhuang PY,Zhang JB,Xu HX,Kong LQ,Wu WZ,Qin LX,Tang ZY.Bevacizumab enhances chemosensitivity of hepatocellular carcinoma to adriamycin related to inhibition of survivin expression.J Cancer Res Clin Oncol,2011,137:505-512.

91.Xu HX,Zhu XD,Zhuang PY,Zhang JB,Zhang W,Kong LQ,Wang WQ,Liang Y,Wu WZ,Wang L,Fan J,Tang ZY,Sun HC.Expression and prognostic significance of placental growth factor in hepatocellular carcinoma and peritumoral liver tissue.Int J Cancer,2011,128:1559-1569.

92.Yang B,Zou J,Xia J,Ren Z,Gan Y,Wang Y,Zhang B,Ge N,Wang D,Chen Y,Chen R,Li L,Ye S,Wang X.Risk factors for recurrence of small hepatocellular carcinoma after longterm follow-up of percutaneous radiofrequency ablation.Eur J Radiol,2011,79:196-200.

93.Yu L,Dai Z,Wang Z,Fan J,Zhou J.Prognostic indicators for tumor recurrence after liver transplantation in hepatocellular carcinoma and related molecular targeted therapy.Oncology,2011,81(Suppl 1):116-122.

94.Zhang S,Shu H,Luo K,Kang X,Zhang Y,Lu H,Liu Y.N-linked glycan changes of serum haptoglobin beta chain in liver disease patients.Mol Biosyst,2011,7:1621-1628.

95.Zhao YM,Wang L,Dai Z,Wang DD,Hei ZY,Zhang N,Fu XT,Wang XL,Zhang SC,Qin LX,Tang ZY,Zhou J,Fan J.Validity of plasma macrophage migration inhibitory factor for diagnosis and prognosis of hepatocellular carcinoma.Int J Cancer,2011,129:2463-2472.

96.Zhou S,Tan C,Dai Z,Zhu H,Xu M,Zhou Z,Wang W,Zhao Y,Fu X,Zhou J,Fan J.Tacrolimus enhances the invasion potential of hepatocellular carcinoma cells and promotes lymphatic metastasis in a rat model of hepatocellular carcinoma:involvement of vascular endothelial growth factor-C.Transplant Proc,2011,43:2747-2754.

97.Zhu K,Dai Z,Pan Q,Wang Z,Yang GH,Yu L,Ding ZB,Shi GM,Ke AW,Yang XR,Tao ZH,Zhao YM,Qin Y,Zeng HY,Tang ZY,Fan J,Zhou J.Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition.Clin Cancer Res,2011,17:7294-7302.

98.Zhu XD,Zhang JB,Fan PL,Xiong YQ,Zhuang PY,Zhang W,Xu HX,Gao DM,Kong LQ,Wang L,Wu WZ,Tang ZY,Ding H,Sun HC.Antiangiogenic effects of pazopanib in xenograft hepatocellular carcinoma models:evaluation by quantitative contrast-enhanced ultrasonography.BMC Cancer,2011,11:28.

99.Chen R,Cui J,Xu C,Xue T,Guo K,Gao D,Liu Y,Ye S,Ren Z.The significance of MMP-9 over MMP-2 in HCC invasiveness and recurrence of hepatocellular carcinoma after curative resection.Ann Surg Oncol,2012,19(Suppl 3):S375-S384.

100.Chen RX,Xia YH,Xue TC,Ye SL.Suppression of microRNA-96 expression inhibits the invasion of hepatocellular carcinoma cells.Mol Med Rep,2012,5:800-804.

101.Gao Q,Shi Y,Wang X,Zhou J,Qiu S,Fan J.Translational medicine in hepatocellular carcinoma.Front Med,2012,6:122-133.

102.Gao Q,Zhao YJ,Wang XY,Qiu SJ,Shi YH,Sun J,Yi Y,Shi JY,Shi GM,Ding ZB,Xiao YS,Zhao ZH,Zhou J,He XH,Fan J.CXCR6 upregulation contributes to a proinflammatory tumor microenvironment that drives metastasis and poor patient outcomes in hepatocellular carcinoma.Cancer Res,2012,72:3546-3556.

103.Gu FM,Gao Q,Shi GM,Zhang X,Wang J,Jiang JH,Wang XY,Shi YH,Ding ZB,Fan J,Zhou J.Intratumoral IL-17(+)cells and neutrophils show strong prognostic significance in intrahepatic cholangiocarcinoma.Ann Surg Oncol,2012,19:2506-2514.

104.Huang C,Ding G,Gu C,Zhou J,Kuang M,Ji Y,He Y,Kondo T,Fan J.Decreased selenium-binding protein 1 enhances glutathione peroxidase 1 activity and downregulates HIF-1alpha to promote hepatocellular carcinoma invasiveness.Clin Cancer Res,2012,18:3042-3053.

105.Huang XY,Shi GM,Devbhandari RP,Ke AW,Wang Y,Wang XY,Wang Z,Shi YH,Xiao YS,Ding ZB,Dai Z,Xu Y,Jia WP,Tang ZY,Fan J,Zhou J.Low level of low-density lipoprotein receptor-related protein 1 predicts an unfavorable prognosis of hepatocellular carcinoma after curative resection.PLoS One,2012,7:e32775.

106.Jia QA,Ren ZG,Bu Y,Wang ZM,Zhang QB,Liang L,Jiang XM,Zhang QB,Tang ZY.Herbal Compound“Songyou Yin”Renders Hepatocellular Carcinoma Sensitive to Oxaliplatin through Inhibition of Stemness.Evid Based Complement Alternat Med,2012,2012:908601.

107.Jiang XM,Zhang JB,Xiong J,Huang XX,Ren ZG.Altered distribution and expression pattern of E-cadherin in hepatocellular carcinomas:correlations with prognosis and clinical features.Asian Pac J Cancer Prev,2012,13:6455-6461.

108.Kong J,Kong L,Kong J,Ke S,Gao J,Ding X,Zheng L,Sun H,Sun W.After insufficient radiofrequency ablation,tumor-associated endothelial cells exhibit enhanced angiogenesis and promote invasiveness of residual hepatocellular carcinoma.J Transl Med,2012,10:230.

109.Li GC,Ye QH,Dong QZ,Ren N,Jia HL,Qin LX.TGF beta1 and related-Smads contribute to pulmonary metastasis of hepatocellular carcinoma in mice model.J Exp Clin Cancer Res,2012,31:93.

110.Li QL,Gu FM,Wang Z,Jiang JH,Yao LQ,Tan CJ,Huang XY,Ke AW,Dai Z,Fan J,Zhou J.Activation of PI3K/AKT and MAPK pathway through a PDGFRbeta-dependent feedback loop is involved in rapamycin resistance in hepatocellular carcinoma.PLoS One,2012,7:e33379.

111.Liao R,Sun TW,Yi Y,Wu H,Li YW,Wang JX,Zhou J,Shi YH,Cheng YF,Qiu SJ,Fan J.Expression of TREM-1 in hepatic stellate cells and prognostic value in hepatitis B-related hepatocellular carcinoma.Cancer Sci,2012,103:984-992.

112.Liu WR,Shi YH,Peng YF,Fan J.Epigenetics of hepatocellular carcinoma:a new horizon.Chin Med J(Engl),2012,125:2349-2360.

113.Qin LX.Inflammatory immune responses in tumor microenvironment and metastasis of hepatocellular carcinoma.Cancer Microenviron,2012,5:203-209.

114.Song K,Gao Q,Zhou J,Qiu SJ,Huang XW,Wang XY,Fan J.Prognostic significance and clinical relevance of Sprouty 2 protein expression in human hepatocellular carcinoma.Hepatobiliary Pancreat Dis Int,2012,11:177-184.

115.Sun TW,Gao Q,Qiu SJ,Zhou J,Wang XY,Yi Y,Shi JY,Xu YF,Shi YH,Song K,Xiao YS,Fan J.B7-H3 is expressed in human hepatocellular carcinoma and is associated with tumor aggressiveness and postoperative recurrence.Cancer Immunol Immunother,2012,61:2171-2182.

116.Wang LR,Zhou JM,Zhao YM,He HW,Chai ZT,Wang M,Ji Y,Chen Y,Liu C,Sun HC,Wu WZ,Ye QH,Zhou J,Fan J,Tang ZY,Wang L.Clinical experience with primary hepatic epithelioid hemangioendothelioma:retrospective study of 33 patients.World J Surg,2012,36:2677-2683.

117.Wang WQ,Liu L,Sun HC,Fu YL,Xu HX,Chai ZT,Zhang QB,Kong LQ,Zhu XD,Lu L,Ren ZG,Tang ZY.Tanshinone IIA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization.J Hematol Oncol,2012,5:69.

118.Wang Y,Chen Y,Ge N,Zhang L,Xie X,Zhang J,Chen R,Wang Y,Zhang B,Xia J,Gan Y,Ren Z,Ye S.Prognostic significance of alpha-fetoprotein status in the outcome of hepatocellular carcinoma after treatment of transarterial chemoembolization.Ann Surg Oncol,2012,19:3540-3546.

119.Wu H,Chen P,Liao R,Li YW,Yi Y,Wang JX,Sun TW,Zhou J,Shi YH,Yang XR,Jin JJ,Cheng YF,Fan J,Qiu SJ.Overexpression of galectin-1 is associated with poor prognosis in human hepatocellular carcinoma following resection.J Gastroenterol Hepatol,2012,27:1312-1319.

120.Xu Y,Chenna V,Hu C,Sun HX,Khan M,Bai H,Yang XR,Zhu QF,Sun YF,Maitra A,Fan J,Anders RA.Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1(Nano H HI)inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma.Clin Cancer Res,2012,18:1291-1302.

121.Xue TC,Chen RX,Han D,Chen J,Xue Q,Gao DM,Sun RX,Tang ZY,Ye SL.Downregulation of CXCR7 inhibits the growth and lung metastasis of human hepatocellular carcinoma cells with highly metastatic potential.Exp Ther Med,2012,3:117-123.

122.Yan J,Zhuo S,Chen G,Tan C,Zhu W,Lu J,Fan J,Chen J,Zhou J.Use of multiphoton microscopy to diagnose liver cancer and lung metastasis in an orthotopic rat model.Scanning,2012,34:271-277.

123.Yan J,Zhuo S,Chen G,Wu X,Zhou D,Xie S,Jiang J,Ying M,Jia F,Chen J,Zhou J.Preclinical study of using multiphoton microscopy to diagnose liver cancer and differentiate benign and malignant liver lesions.J Biomed Opt,2012,17:026004.

124.Yin X,Li YW,Zhang BH,Ren ZG,Qiu SJ,Yi Y,Fan J.Coexpression of stemness factors Oct4 and Nanog predict liver resection.Ann Surg Oncol,2012,19:2877-2887.

125.Yin X,Zhang BH,Qiu SJ,Ren ZG,Zhou J,Chen XH,Zhou Y,Fan J.Combined hepatocellular carcinoma and cholangiocarcinoma:clinical features,treatment modalities,and prognosis.Ann Surg Oncol,2012,19:2869-2876.

126.Zeng L,Yu J,Huang T,Jia H,Dong Q,He F,Yuan W,Qin L,Li Y,Xie L.Differential combinatorial regulatory network analysis related to venous metastasis of hepatocellular carcinoma.BMC Genomics,2012,13(Suppl 8):S14.

127.Zhang JB,Sun HC,Jia WD,Zhuang PY,Qian YB,Zhu XD,Kong LQ,Wang L,Wu WZ,Tang ZY.Up-regulation of platelet-derived growth factor-A is responsible for the failure of reinitiated interferon alpha treatment in hepatocellular carcinoma.BMC Cancer,2012,12:439.

128.Zhang L,Xie XY,Wang Y,Wang YH,Chen Y,Ren ZG.Treatment of radiation-induced hemorrhagic gastritis with prednisolone:a case report.World J Gastroenterol,2012,18:7402-7404.

129.Zhang X,Yang XR,Huang XW,Wang WM,Shi RY,Xu Y,Wang Z,Qiu SJ,Fan J,Zhou J.Sorafenib in treatment of patients with advanced hepatocellular carcinoma:a systematic review.Hepatobiliary Pancreat Dis Int,2012,11:458-466.

130.Zhao YM,Zhou JM,Wang LR,He HW,Wang XL,Tao ZH,Sun HC,Wu WZ,Fan J,Tang ZY,Wang L.HIWI is associated with prognosis in patients with hepatocellular carcinoma after curative resection.Cancer,2012,118:2708-2717.

131.Zhou J,Shi YH,Fan J.Circulating cell-free nucleic acids:promising biomarkers of hepatocellular carcinoma.Semin Oncol,2012,39:440-448.

132.Zhou SL,Dai Z,Zhou ZJ,Wang XY,Yang GH,Wang Z,Huang XW,Fan J,Zhou J.Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma.Hepatology,2012,56:2242-2254.

133.Zhou Y,Yin X,Ying J,Zhang B.Golgi protein 73 versus alpha-fetoprotein as a biomarker for hepatocellular carcinoma:a diagnostic meta-analysis.BMC Cancer,2012,12:17.

134.Zhu HT,Dong QZ,Sheng YY,Wei JW,Wang G,Zhou HJ,Ren N,Jia HL,Ye QH,Qin LX.MicroRNA-29a-5p is a novel predictor for early recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection.PLoS One,2012,7:e52393.

135.Zhu HT,Dong QZ,Wang G,Zhou HJ,Ren N,Jia HL,Ye QH,Qin LX.Identification of suitable reference genes for qRT-PCR analysis of circulating micro RNAs in hepatitis B virusinfected patients.Mol Biotechnol,2012,50:49-56.

136.Zhu XC,Dong QZ,Zhang XF,Deng B,Jia HL,Ye QH,Qin LX,Wu XZ.microRNA-29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma.Int J Mol Med,2012,30:1321-1326.

137.Chai ZT,Kong J,Zhu XD,Zhang YY,Lu L,Zhou JM,Wang LR,Zhang KZ,Zhang QB,Ao JY,Wang M,Wu WZ,Wang L,Tang ZY,Sun HC.Micro RNA-26a inhibits angiogenesis by down-regulating VEGFA through the PIK3C2alpha/Akt/HIF-1alpha pathway in hepatocellular carcinoma.PLoS One,2013,8:e77957.

138.Chen X,Zhang B,Yin X,Ren Z,Qiu S,Zhou J.Lipiodolized transarterial chemoembolization in hepatocellular carcinoma patients after curative resection.J Cancer Res Clin Oncol,2013,139:773-781.

139.Chen YJ,Zhu JM,Wu H,Fan J,Zhou J,Hu J,Yu Q,Liu TT,Yang L,Wu CL,Guo XL,Huang XW,Shen XZ.Circulating micro RNAs as a Fingerprint for Liver Cirrhosis.PLoS One,2013,8:e66577.

140.Deng B,Zhang XF,Zhu XC,Huang H,Jia HL,Ye QH,Dong QZ,Qin LX.Correlation and prognostic value of osteopontin and Bcl-2 in hepatocellular carcinoma patients after curative resection.Oncol Rep,2013,30:2795-2803.

141.Deng L,Ren Z,Jia Q,Wu W,Shen H,Wang Y.Schedule-dependent antitumor effects of 5-fluorouracil combined with sorafenib in hepatocellular carcinoma.BMC Cancer,2013,13:363.

142.Dong QZ,Zhang XF,Zhao Y,Jia HL,Zhou HJ,Dai C,Sun HJ,Qin Y,Zhang WD,Ren N,Ye QH,Qin LX.Osteopontin promoter polymorphisms at locus-443 significantly affect the metastasis and prognosis of human hepatocellular carcinoma.Hepatology,2013,57:1024-1034.

143.Hu J,Wang Z,Tan CJ,Liao BY,Zhang X,Xu M,Dai Z,Qiu SJ,Huang XW,Sun J,Sun QM,He YF,Song K,Pan Q,Wu Y,Fan J,Zhou J.Plasma microRNA,a potential biomarker for acute rejection after liver transplantation.Transplantation,2013,95:991-999.

144.Huang C,Wang Y,Liu S,Ding G,Liu W,Zhou J,Kuang M,Ji Y,Kondo T,Fan J.Quantitative proteomic analysis identified paraoxonase 1 as a novel serum biomarker for microvascular invasion in hepatocellular carcinoma.J Proteome Res,2013,12:1838-1846.

145.Huang XY,Ke AW,Shi GM,Zhang X,Zhang C,Shi YH,Wang XY,Ding ZB,Xiao YS,Yan J,Qiu SJ,Fan J,Zhou J.alphaB-crystallin complexes with 14-3-3zeta to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinoma.Hepatology,2013,57:2235-2247.

146.Jia QA,Wang ZM,Ren ZG,Bu Y,Xie XY,Wang YH,Zhang L,Zhang QB,Xue TC,Deng LF,Tang ZY.Herbal compound“Songyou Yin”attenuates hepatoma cell invasiveness and metastasis through downregulation of cytokines secreted by activated hepatic stellate cells.BMC Complement Altern Med,2013,13:89.

147.Jiang JH,Gao Q,Shen XZ,Yu Y,Gu FM,Yan J,Pan JF,Jin F,Fan J,Zhou J,Huang XW.An X-chromosomal association study identifies a susceptibility locus at Xq22.1 for hepatitis B virus-related hepatocellular carcinoma.Clin Res Hepatol Gastroenterol,2013,37:586-595.

148.Jin GZ,Dong H,Yu WL,Li Y,Lu XY,Yu H,Xian ZH,Dong W,Liu YK,Cong WM,Wu MC.A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values.BMC Cancer,2013,13:161.

149.Kong LQ,Zhu XD,Xu HX,Zhang JB,Lu L,Wang WQ,Zhang QB,Wu WZ,Wang L,Fan J,Tang ZY,Sun HC.The clinical significance of the CD163+and CD68+macrophages in patients with hepatocellular carcinoma.PLoS One,2013,8:e59771.

150.Li G,Qin L,Ye Q,Dong Q,Ren N,Jia H.Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-beta/Smad pathway in mice.Exp Ther Med,2013,5:133-137.

151.Li GC,Ye QH,Dong QZ,Ren N,Jia HL,Qin LX.Mesenchymal stem cells seldomly fuse with hepatocellular carcinoma cells and are mainly distributed in the tumor stroma in mouse models.Oncol Rep,2013,29:713-719.

152.Li S,Mo C,Peng Q,Kang X,Sun C,Jiang K,Huang L,Lu Y,Sui J,Qin X,Liu Y.Cell surface glycan alterations in epithelial mesenchymal transition process of Huh7 hepatocellular carcinoma cell.PLoS One,2013,8:e71273.

153.Liao R,Sun J,Wu H,Yi Y,Wang JX,He HW,Cai XY,Zhou J,Cheng YF,Fan J,Qiu SJ.High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma.J Exp Clin Cancer Res,2013,32:3.

154.Liao R,Wu H,Yi Y,Wang JX,Cai XY,He HW,Cheng YF,Zhou J,Fan J,Sun J,Qiu SJ.Clinical significance and gene expression study of human hepatic stellate cells in HBV relatedhepatocellular carcinoma.J Exp Clin Cancer Res,2013,32:22.

155.Liu Y,Zhang JB,Qin Y,Wang W,Wei L,Teng Y,Guo L,Zhang B,Lin Z,Liu J,Ren ZG,Ye QH,Xie Y.PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1alpha expression and protein stability.Hepatology,2013,58:692-705.

156.Lu L,Sun HC,Zhang W,Chai ZT,Zhu XD,Kong LQ,Wang WQ,Zhang KZ,Zhang YY,Zhang QB,Ao JY,Li JQ,Wang L,Wu WZ,Tang ZY.Aspirin minimized the pro-metastasis effect of sorafenib and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma.PLoS One,2013,8:e65023.

157.Peng YF,Shi YH,Ding ZB,Ke AW,Gu CY,Hui B,Zhou J,Qiu SJ,Dai Z,Fan J.Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells.Autophagy,2013,9:2056-2068.

158.Peng YF,Shi YH,Ding ZB,Zhou J,Qiu SJ,Hui B,Gu CY,Yang H,Liu WR,Fan J.alpha-Fetoprotein promoter-driven Cre/Lox P-switched RNA interference for hepatocellular carcinoma tissue-specific target therapy.PLoS One,2013,8:e53072.

159.Peng YF,Shi YH,Shen YH,Ding ZB,Ke AW,Zhou J,Qiu SJ,Fan J.Promoting colonization in metastatic HCC cells by modulation of autophagy.PLoS One,2013,8:e74407.

160.Shi JY,Gao Q,Wang ZC,Zhou J,Wang XY,Min ZH,Shi YH,Shi GM,Ding ZB,Ke AW,Dai Z,Qiu SJ,Song K,Fan J.Margin-infiltrating CD20(+)B cells display an atypical memory phenotype and correlate with favorable prognosis in hepatocellular carcinoma.Clin Cancer Res,2013,19:5994-6005.

161.Shi RY,Yang XR,Shen QJ,Yang LX,Xu Y,Qiu SJ,Sun YF,Zhang X,Wang Z,Zhu K,Qin WX,Tang ZY,Fan J,Zhou J.High expression of Dickkopf-related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery.Cancer,2013,119:993-1003.

162.Sun C,Sun L,Jiang K,Gao DM,Kang XN,Wang C,Zhang S,Huang S,Qin X,Li Y,Liu YK.NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway.Int J Biochem Cell Biol,2013,45:1099-1108.

163.Sun C,Sun L,Li Y,Kang X,Zhang S,Liu Y.Sox2 expression predicts poor survival of hepatocellular carcinoma patients and it promotes liver cancer cell invasion by activating Slug.Med Oncol,2013,30:503.

164.Sun HX,Xu Y,Yang XR,Wang WM,Bai H,Shi RY,Nayar SK,Devbhandari RP,He YZ,Zhu QF,Sun YF,Hu B,Khan M,Anders RA,Fan J.Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/E2F transcription factor 1-dependent apoptotic pathway.Hepatology,2013,57:1088-1097.

165.Sun X,Wang Z,Zhai S,Cheng Y,Liu J,Liu B.In vitro cytotoxicity of silver nanoparticles in primary rat hepatic stellate cells.Mol Med Rep,2013,8:1365-1372.

166.Sun YF,Xu Y,Yang XR,Guo W,Zhang X,Qiu SJ,Shi RY,Hu B,Zhou J,Fan J.Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection.Hepatology,2013,57:1458-1468.

167.Tao ZH,Wan JL,Zeng LY,Xie L,Sun HC,Qin LX,Wang L,Zhou J,Ren ZG,Li YX,Fan J,Wu WZ.miR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma.J Exp Med,2013,210:789-803.

168.Wang C,Jiang K,Gao D,Kang X,Sun C,Zhang Q,Li Y,Sun L,Zhang S,Guo K,Liu Y.Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78.PLoS One,2013,8:e55981.

169.Wang H,Song K,Chen Z,Yu Y.Poor metabolizers at the cytochrome P450 2C19 loci is at increased risk of developing cancer in Asian populations.PLoS One,2013,8:e73126.

170.Wang P,Dong Q,Zhang C,Kuan PF,Liu Y,Jeck WR,Andersen JB,Jiang W,Savich GL,Tan TX,Auman JT,Hoskins JM,Misher AD,Moser CD,Yourstone SM,Kim JW,Cibulskis K,Getz G,Hunt HV,Thorgeirsson SS,Roberts LR,Ye D,Guan KL,Xiong Y,Qin LX,Chiang DY.Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas.Oncogene,2013,32:3091-3100.

171.Wang YH,Dong YY,Wang WM,Xie XY,Wang ZM,Chen RX,Chen J,Gao DM,Cui JF,Ren ZG.Vascular endothelial cells facilitated HCC invasion and metastasis through the Akt and NF-kappaB pathways induced by paracrine cytokines.J Exp Clin Cancer Res,2013,32:51.

172.Wang ZC,Gao Q,Shi JY,Yang LX,Zhou J,Wang XY,Shi YH,Ke AW,Shi GM,Ding ZB,Dai Z,Qiu SJ,Fan J.Genetic polymorphism of the kinesin-like protein KIF1B gene and the risk of hepatocellular carcinoma.PLoS One,2013,8:e62571.

173.Wu H,Chen P,Liao R,Li YW,Yi Y,Wang JX,Cai XY,He HW,Jin JJ,Cheng YF,Fan J,Sun J,Qiu SJ.Intratumoral regulatory T cells with higher prevalence and more suppressive activity in hepatocellular carcinoma patients.J Gastroenterol Hepatol,2013,28:1555-1564.

174.Xia YH,Wang ZM,Chen RX,Ye SL,Sun RX,Xue Q,Huang Y.T-cell apoptosis induced by intratumoral activated hepatic stellate cells is associated with lung metastasis in hepatocellular carcinoma.Oncol Rep,2013,30:1175-1184.

175.Xiao YS,Gao Q,Xu XN,Li YW,Ju MJ,Cai MY,Dai CX,Hu J,Qiu SJ,Zhou J,Fan J.Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.PLoS One,2013,8:e70345.

176.Xu J,Xia J.NRP-1 silencing suppresses hepatocellular carcinoma cell growth in vitro and in vivo.Exp Ther Med,2013,5:150-154.

177.Xue TC,Chen RX,Ren ZG,Zou JH,Tang ZY,Ye SL.Transmembrane receptor CXCR7 increases the risk of extrahepatic metastasis of relatively well-differentiated hepatocellular carcinoma through upregulation of osteopontin.Oncol Rep,2013,30:105-110.

178.Xue TC,Xie XY,Zhang L,Yin X,Zhang BH,Ren ZG.Transarterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus:a meta-analysis.BMC Gastroenterol,2013,13:60.

179.Yan J,Tan C,Gu F,Jiang J,Xu M,Huang X,Dai Z,Wang Z,Fan J,Zhou J.Sorafenib delays recurrence and metastasis after liver transplantation in a rat model of hepatocellular carcinoma with high expression of phosphorylated extracellular signal-regulated kinase.Liver Transpl,2013,19:507-520.

180.Yang X,Liang L,Zhang XF,Jia HL,Qin Y,Zhu XC,Gao XM,Qiao P,Zheng Y,Sheng YY,Wei JW,Zhou HJ,Ren N,Ye QH,Dong QZ,Qin LX.MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin-6-Stat3 pathway.Hepatology,2013,58:158-170.

181.Yi Y,He HW,Wang JX,Cai XY,Li YW,Zhou J,Cheng YF,Jin JJ,Fan J,Qiu SJ.The functional impairment of HCC-infiltrating gammadelta T cells,partially mediated by regulatory T cells in a TGFbeta-and IL-10-dependent manner.J Hepatol,2013,58:977-983.

182.Yin X,Li YW,Jin JJ,Zhou Y,Ren ZG,Qiu SJ,Zhang BH.The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma.Oncol Lett,2013,5:1155-1162.

183.Yin X,Zheng SS,Zhang BH,Zhou Y,Chen XH,Ren ZG,Qiu SJ,Fan J.Elevation of serum gamma-glutamyltransferase as a predictor of aggressive tumor behaviors and unfavorable prognosis in patients with intrahepatic cholangiocarcinoma:analysis of a large monocenter study.Eur J Gastroenterol Hepatol,2013,25:1408-1414.

184.Zhang C,Bai DS,Huang XY,Shi GM,Ke AW,Yang LX,Yang XR,Zhou J,Fan J.Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma.PLoS One,2013,8:e54619.

185.Zhang JB,Guo K,Sun HC,Zhu XD,Zhang B,Lin ZH,Zhang BH,Liu YK,Ren ZG,Fan J.Prognostic value of peritumoral heat-shock factor-1 in patients receiving resection of hepatocellular carcinoma.Br J Cancer,2013,109:1648-1656.

186.Zhang QB,Sun HC,Zhang KZ,Jia QA,Bu Y,Wang M,Chai ZT,Zhang QB,Wang WQ,Kong LQ,Zhu XD,Lu L,Wu WZ,Wang L,Tang ZY.Suppression of natural killer cells by sorafenib contributes to prometastatic effects in hepatocellular carcinoma.PLoS One,2013,8:e55945.

187.Zhang S,Jiang K,Sun C,Lu H,Liu Y.Quantitative analysis of site-specific N-glycans on sera haptoglobin beta chain in liver diseases.Acta Biochim Biophys Sin(Shanghai),2013,45:1021-1029.

188.Zheng SS,Chen XH,Yin X,Zhang BH.Prognostic significance of HIF-1alpha expression in hepatocellular carcinoma:a meta-analysis.PLoS One,2013,8:e65753.

189.Zhou C,Zhou HJ,Zhang XF,Lou LL,Ye QH,Zheng Y,Wang J,Zhu HT,Dong QZ,Jia HL,Zhu WW,Guo L,Zhao Y,Gao DM,Qin LX.Postoperative serum osteopontin level is a novel monitor for treatment response and tumor recurrence after resection of hepatitis B-related hepatocellular carcinoma.Ann Surg Oncol,2013,20:929-937.

190.Zhou ZJ,Dai Z,Zhou SL,Fu XT,Zhao YM,Shi YH,Zhou J,Fan J.Overexpression of Hn RNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma.Int J Cancer,2013,132:1080-1089.

191.Zhu K,Dai Z,Zhou J.Biomarkers for hepatocellular carcinoma:progression in early diagnosis,prognosis,and personalized therapy.Biomark Res,2013,1:10.

192.Zhu K,Pan Q,Zhang X,Kong LQ,Fan J,Dai Z,Wang L,Yang XR,Hu J,Wan JL,Zhao YM,Tao ZH,Chai ZT,Zeng HY,Tang ZY,Sun HC,Zhou J.MiR-146a enhances angiogenic activity of endothelial cells in hepatocellular carcinoma by promoting PDGFRA expression.Carcinogenesis,2013,34:2071-2079.

193.Zhu WW,Guo JJ,Guo L,Jia HL,Zhu M,Zhang JB,Loffredo CA,Forgues M,Huang H,Xing XJ,Ren N,Dong QZ,Zhou HJ,Ren ZG,Zhao NQ,Wang XW,Tang ZY,Qin LX,Ye QH.Evaluation of midkine as a diagnostic serum biomarker in hepatocellular carcinoma.Clin Cancer Res,2013,19:3944-3954.

194.Zhu XD,Sun HC,Xu HX,Kong LQ,Chai ZT,Lu L,Zhang JB,Gao DM,Wang WQ,Zhang W,Zhuang PY,Wu WZ,Wang L,Tang ZY.Antiangiogenic therapy promoted metastasis of hepatocellular carcinoma by suppressing host-derived interleukin-12b in mouse models.Angiogenesis,2013,16:809-820.

195.Zhuang PY,Shen J,Zhu XD,Lu L,Wang L,Tang ZY,Sun HC.Prognostic roles of crosstalk between peritumoral hepatocytes and stromal cells in hepatocellular carcinoma involving peritumoral VEGF-C,VEGFR-1 and VEGFR-3.PLoS One,2013,8:e64598.

196.Zhuang PY,Shen J,Zhu XD,Zhang JB,Tang ZY,Qin LX,Sun HC.Direct transformation of lung microenvironment by interferon-alpha treatment counteracts growth of lung metastasis of hepatocellular carcinoma.PLoS One,2013,8:e58913.

197.Bu Y,Jia QA,Ren ZG,Zhang JB,Jiang XM,Liang L,Xue TC,Zhang QB,Wang YH,Zhang L,Xie XY,Tang ZY.Maintenance of stemness in oxaliplatin-resistant hepatocellular carcinoma is associated with increased autocrine of IGF1.PLoS One,2014,9:e89686.

198.Cai XY,Wang JX,Yi Y,He HW,Ni XC,Zhou J,Cheng YF,Jin JJ,Fan J,Qiu SJ.Low counts of gammadelta T cells in peritumoral liver tissue are related to more frequent recurrence in patients with hepatocellular carcinoma after curative resection.Asian Pac J Cancer Prev,2014,15:775-780.

199.Chen R,Dong Y,Xie X,Chen J,Gao D,Liu Y,Ren Z,Cui J.Screening candidate metastasis-associated genes in three-dimensional HCC spheroids with different metastasis potential.Int J Clin Exp Pathol,2014,7:2527-2535.

200.Chen RX,Song HY,Dong YY,Hu C,Zheng QD,Xue TC,Liu XH,Zhang Y,Chen J,Ren ZG,Liu YK,Cui JF.Dynamic expression patterns of differential proteins during early invasion of hepatocellular carcinoma.PLoS One,2014,9:e88543.

201.Dai Z,Zhou SL,Zhou ZJ,Bai DS,Xu XY,Fu XT,Chen Q,Zhao YM,Zhu K,Yu L,Yang GH,Wang Z,Wu WZ,Zhou J,Fan J.Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways.J Pathol,2014,234:316-328.

202.Dong Y,Xie X,Wang Z,Hu C,Zheng Q,Wang Y,Chen R,Xue T,Chen J,Gao D,Wu W,Ren Z,Cui J.Increasing matrix stiffness upregulates vascular endothelial growth factor expression in hepatocellular carcinoma cells mediated by integrin beta1.Biochem Biophys Res Commun,2014,444:427-432.

203.Fan Y,Ge N,Wang X,Sun W,Mao R,Bu W,Creighton CJ,Zheng P,Vasudevan S,An L,Yang J,Zhao YJ,Zhang H,Li XN,Rao PH,Leung E,Lu YJ,Gray JW,Schiff R,Hilsenbeck SG,Osborne CK,Yang J,Zhang H.Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells.J Pathol,2014,232:75-86.

204.Fang TT,Sun XJ,Chen J,Zhao Y,Sun RX,Ren N,Liu BB.Long non-coding RNAs are differentially expressed in hepatocellular carcinoma cell lines with differing metastatic potential.Asian Pac J Cancer Prev,2014,15:10513-10524.

205.Gao Q,Yu GY,Shi JY,Li LH,Zhang WJ,Wang ZC,Yang LX,Duan M,Zhao H,Wang XY,Zhou J,Qiu SJ,Jeong LS,Jia LJ,Fan J.Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target.Oncotarget,2014,5:7820-7832.

206.Gao Q,Zhao YJ,Wang XY,Guo WJ,Gao S,Wei L,Shi JY,Shi GM,Wang ZC,Zhang YN,Shi YH,Ding J,Ding ZB,Ke AW,Dai Z,Wu FZ,Wang H,Qiu ZP,Chen ZA,Zhang ZF,Qiu SJ,Zhou J,He XH,Fan J.Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients.Gastroenterology,2014,146:1397-1407.

207.Guo W,Yang XR,Sun YF,Shen MN,Ma XL,Wu J,Zhang CY,Zhou Y,Xu Y,Hu B,Zhang X,Zhou J,Fan J.Clinical significance of Ep CAM m RNA-positive circulating tumor cells in hepatocellular carcinoma by an optimized negative enrichment and qRT-PCR-based platform.Clin Cancer Res,2014,20:4794-4805.

208.Hu B,Yang XR,Xu Y,Sun YF,Sun C,Guo W,Zhang X,Wang WM,Qiu SJ,Zhou J,Fan J.Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma.Clin Cancer Res,2014,20:6212-6222.

209.Hu J,Wang Z,Liao BY,Yu L,Gao X,Lu S,Wang S,Dai Z,Zhang X,Chen Q,Qiu SJ,Wu Y,Zhu H,Fan J,Zhou J,Wang J.Human miR-1228 as a stable endogenous control for the quantification of circulating microRNAs in cancer patients.Int J Cancer,2014,135:1187-1194.

210.Huang P,Lopez Villar E.Possible mechanism and clinical potentials of allostery.Clin Transl Med,2014,3:18.

211.Huang P,Xu X,Wang L,Zhu B,Wang X,Xia J.The role of EGF-EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironment.J Cell Mol Med,2014,18:218-230.

212.Huang XY,Zhang C,Cai JB,Shi GM,Ke AW,Dong ZR,Zhang PF,Fan J,Peng BG,Zhou J.Comprehensive multiple molecular profile of epithelial mesenchymal transition in intrahepatic cholangiocarcinoma patients.PLoS One,2014,9:e96860.

213.Huang Y,Yang X,Zhao F,Shen Q,Wang Z,Lv X,Hu B,Yu B,Fan J,Qin W.Overexpression of Dickkopf-1 predicts poor prognosis for patients with hepatocellular carcinoma after orthotopic liver transplantation by promoting cancer metastasis and recurrence.Med Oncol,2014,31:966.

214.Jiang JH,Gao Q,Ke AW,Yu Y,Shi GM,Fan J,Zhou J,Huang XW.Prognostic significance of nuclear RNA export factor 3 in hepatocellular carcinoma.Oncol Lett,2014,7:641-646.

215.Jiang JH,Liu YF,Ke AW,Gu FM,Yu Y,Dai Z,Gao Q,Shi GM,Liao BY,Xie YH,Fan J,Huang XW,Zhou J.Clinical significance of the ubiquitin ligase UBE3C in hepatocellular carcinoma revealed by exome sequencing.Hepatology,2014,59:2216-2227.

216.Kong Q,Yuan J,Gao L,Zhao S,Jiang W,Huang Y,Bie Z.Identification of suitable reference genes for gene expression normalization in qRT-PCR analysis in watermelon.PLoS One,2014,9:e90612.

217.Li S,Mo C,Huang S,Yang S,Lu Y,Peng Q,Wang J,Deng Y,Qin X,Liu Y.Overexpressed Testis-specific Protein Y-encoded 1 as a novel biomarker for male hepatocellular carcinoma.PLoS One,2014,9:e89219.

218.Li YW,Wang JX,Yin X,Qiu SJ,Wu H,Liao R,Yi Y,Xiao YS,Zhou J,Zhang BH,Fan J.Decreased expression of GATA2 promoted proliferation,migration and invasion of Hep G2 in vitro and correlated with poor prognosis of hepatocellular carcinoma.PLoS One,2014,9:e87505.

219.Lin Q,Ye Q,Zhu D,Wei Y,Ren L,Ye L,Feng Q,Xu P,Zheng P,Lv M,Fan J,Xu J.Determinants of long-term outcome in patients undergoing simultaneous resection of synchronous colorectal liver metastases.PLoS One,2014,9:e105747.

220.Lin ZH,Wang L,Zhang JB,Liu Y,Li XQ,Guo L,Zhang B,Zhu WW,Ye QH.MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway.Int J Oncol,2014,45:629-640.

221.Liu T,Zhang S,Chen J,Jiang K,Zhang Q,Guo K,Liu Y.The transcriptional profiling of glycogenes associated with hepatocellular carcinoma metastasis.PLoS One,2014,9:e107941.

222.Liu WR,Tian MX,Jin L,Yang LX,Ding ZB,Shen YH,Peng YF,Zhou J,Qiu SJ,Dai Z,Fan J,Shi YH.High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma.J Exp Clin Cancer Res,2014,33:32.

223.Ma H,Zhang L,Tang B,Wang Y,Chen R,Zhang B,Chen Y,Ge N,Wang Y,Gan Y,Ye S,Ren Z.gamma-Glutamyltranspeptidase is a prognostic marker of survival and recurrence in radiofrequency-ablation treatment of hepatocellular carcinoma.Ann Surg Oncol,2014,21:3084-3089.

224.Ni XC,Yi Y,Fu YP,He HW,Cai XY,Wang JX,Zhou J,Fan J,Qiu SJ.Serum amyloid A is a novel prognostic biomarker in hepatocellular carcinoma.Asian Pac J Cancer Prev,2014,15:10713-10718.

225.Shen YH,Chen S,Peng YF,Shi YH,Huang XW,Yang GH,Ding ZB,Yi Y,Zhou J,Qiu SJ,Fan J,Ren N.Quantitative assessment of the effect of glutathione S-transferase genes GSTM1 and GSTT1 on hepatocellular carcinoma risk.Tumour Biol,2014,35:4007-4015.

226.Shen YH,Chen S,Zhang WT,Ji Y,Yu L,Sun HC,Qiu SJ,Ren N,Zhou J.Clinical analysis of gastroenteropancreatic neuroendocrine tumor with liver metastasis,compared with primary hepatic neuroendocrine tumor.J Cancer Res Ther,2014,(10 Suppl):276-280.

227.Song FN,Duan M,Liu LZ,Wang ZC,Shi JY,Yang LX,Zhou J,Fan J,Gao Q,Wang XY.RANKL promotes migration and invasion of hepatocellular carcinoma cells via NF-kappaBmediated epithelial-mesenchymal transition.PLoS One,2014,9:e108507.

228.Tang J,Tao ZH,Wen D,Wan JL,Liu DL,Zhang S,Cui JF,Sun HC,Wang L,Zhou J,Fan J,Wu WZ.MiR-612 suppresses the stemness of liver cancer via Wnt/beta-catenin signaling.Biochem Biophys Res Commun,2014,447:210-215.

229.Tian H,Huang P,Zhao Z,Tang W,Xia J.HIF-1alpha plays a role in the chemotactic migration of hepatocarcinoma cells through the modulation of CXCL6 expression.Cell Physiol Biochem,2014,34:1536-1546.

230.Wang JX,Yi Y,Li YW,Cai XY,He HW,Ni XC,Zhou J,Cheng YF,Jin JJ,Fan J,Qiu SJ.Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection.BMC Cancer,2014,14:297.

231.Wang W,Cheng J,Qin JJ,Voruganti S,Nag S,Fan J,Gao Q,Zhang R.RYBP expression is associated with better survival of patients with hepatocellular carcinoma(HCC)and responsiveness to chemotherapy of HCC cells in vitro and in vivo.Oncotarget,2014,5:11604-11619.

232.Wang ZM,Zhou LY,Liu BB,Jia QA,Dong YY,Xia YH,Ye SL.Rat hepatic stellate cells alter the gene expression profile and promote the growth,migration and invasion of hepatocellular carcinoma cells.Mol Med Rep,2014,10:1725-1733.

233.Wu JC,Jia HL,Li ZR,Zhou KL,Qin LX,Dong QZ,Ren N.Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma.PLoS One,2014,9:e90528.

234.Xu M,Tan C,Hu J,Alwahsh SM,Yan J,Hu J,Dai Z,Wang Z,Zhou J,Fan J,Huang X.Expression of hemopexin in acute rejection of rat liver allograft identified by serum proteomic analysis.Shock,2014,42:65-74.

235.Xu X,Huang P,Tian H,Chen Y,Ge N,Tang W,Yang B,Xia J.Role of lamivudine with transarterial chemoembolization in the survival of patients with hepatocellular carcinoma.J Gastroenterol Hepatol,2014,29:1273-1278.

236.Xu X,Huang P,Yang B,Wang X,Xia J.Roles of CXCL5 on migration and invasion of liver cancer cells.J Transl Med,2014,12:193.

237.Xue TC,Ge NL,Zhang L,Cui JF,Chen RX,You Y,Ye SL,Ren ZG.Goosecoid promotes the metastasis of hepatocellular carcinoma by modulating the epithelial-mesenchymal transition.PLoS One,2014,9:e109695.

238.Xue TC,Jia QA,Bu Y,Chen RX,Cui JF,Tang ZY,Ye SL.CXCR7 correlates with the differentiation of hepatocellular carcinoma and suppresses HNF4alpha expression through the ERK pathway.Oncol Rep,2014,32:2387-2396.

239.Xue TC,Zhang L,Xie XY,Ge NL,Li LX,Zhang BH,Ye SL,Ren ZG.Prognostic significance of the neutrophil-to-lymphocyte ratio in primary liver cancer:a meta-analysis.PLoS One,2014,9:e96072.

240.Xue TC,Zou JH,Chen RX,Cui JF,Tang ZY,Ye SL.Spatial localization of the JAG1/Notch1/osteopontin cascade modulates extrahepatic metastasis in hepatocellular carcinoma.Int J Oncol,2014,45:1883-1890.

241.Yang X,Zhang XF,Lu X,Jia HL,Liang L,Dong QZ,Ye QH,Qin LX.MicroRNA-26a suppresses angiogenesis in human hepatocellular carcinoma by targeting hepatocyte growth factor-c Met pathway.Hepatology,2014,59:1874-1885.

242.Yin X,Zhang L,Wang YH,Zhang BH,Gan YH,Ge NL,Chen Y,Li LX,Ren ZG.Transcatheter arterial chemoembolization combined with radiofrequency ablation delays tumor progression and prolongs overall survival in patients with intermediate(BCLC B)hepatocellular carcinoma.BMC Cancer,2014,14:849.

243.Zhang KZ,Zhang QB,Zhang QB,Sun HC,Ao JY,Chai ZT,Zhu XD,Lu L,Zhang YY,Bu Y,Kong LQ,Tang ZY.Arsenic trioxide induces differentiation of CD133+hepatocellular carcinoma cells and prolongs posthepatectomy survival by targeting GLI1 expression in a mouse model.J Hematol Oncol,2014,7:28.

244.Zhang L,Yin X,Gan YH,Zhang BH,Zhang JB,Chen Y,Xie XY,Ge NL,Wang YH,Ye SL,Ren ZG.Radiofrequency ablation following first-line transarterial chemoembolization for patients with unresectable hepatocellular carcinoma beyond the Milan criteria.BMC Gastroenterol,2014,14:11.

245.Zhang N,Wang L,Chai ZT,Zhu ZM,Zhu XD,Ma DN,Zhang QB,Zhao YM,Wang M,Ao JY,Ren ZG,Gao DM,Sun HC,Tang ZY.Incomplete radiofrequency ablation enhances invasiveness and metastasis of residual cancer of hepatocellular carcinoma cell HCCLM3 via activating beta-catenin signaling.PLoS One,2014,9:e115949.

246.Zhang W,Song TQ,Zhang T,Wu Q,Kong DL,Li Q,Sun HC.Adjuvant interferon for early or late recurrence of hepatocellular carcinoma and mortality from hepatocellular carcinoma following curative treatment:A meta-analysis with comparison of different types of hepatitis.Mol Clin Oncol,2014,2:1125-1134.

247.Zhang ZJ,Yang YK,Wu WZ.Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice.J Transl Med,2014,12:57.

248.Zhou SL,Dai Z,Zhou ZJ,Chen Q,Wang Z,Xiao YS,Hu ZQ,Huang XY,Yang GH,Shi YH,Qiu SJ,Fan J,Zhou J.CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils.Carcinogenesis,2014,35:597-605.

249.Zhou ZJ,Dai Z,Zhou SL,Hu ZQ,Chen Q,Zhao YM,Shi YH,Gao Q,Wu WZ,Qiu SJ,Zhou J,Fan J.HNRNPAB induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by transcriptionally activating SNAIL.Cancer Res,2014,74:2750-2762.

250.Zhu H,Sun Q,Tan C,Xu M,Dai Z,Wang Z,Fan J,Zhou J.Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF1alpha expression in vivo.Mol Med Rep,2014,10:585-592.

251.Zhu K,Pan Q,Jia LQ,Dai Z,Ke AW,Zeng HY,Tang ZY,Fan J,Zhou J.MiR-302c inhibits tumor growth of hepatocellular carcinoma by suppressing the endothelial-mesenchymal transition of endothelial cells.Sci Rep,2014,4:5524.

252.Zhu W,Guo L,Zhang B,Lou L,Lin Z,Zhu X,Ren N,Dong Q,Ye Q,Qin L.Combination of osteopontin with peritumoral infiltrating macrophages is associated with poor prognosis of early-stage hepatocellular carcinoma after curative resection.Ann Surg Oncol,2014,21:1304-1313.

253.Ao JY,Chai ZT,Zhang YY,Zhu XD,Kong LQ,Zhang N,Ye BG,Cai H,Gao DM,Sun HC.Robo1 promotes angiogenesis in hepatocellular carcinoma through the Rho family of guanosine triphosphatases'signaling pathway.Tumour Biol,2015,36:8413-8424.

254.Bu Y,Jia QA,Ren ZG,Xue TC,Zhang QB,Zhang KZ,Zhang QB,You Y,Tian H,Qin LX,Tang ZY.The herbal compound Songyou Yin(SYY)inhibits hepatocellular carcinoma growth and improves survival in models of chronic fibrosis via paracrine inhibition of activated hepatic stellate cells.Oncotarget,2015,6:40068-40080.

255.Cai H,Kong WT,Chen CB,Shi GM,Huang C,Shen YH,Sun HC.Cholelithiasis and the risk of intrahepatic cholangiocarcinoma:a meta-analysis of observational studies.BMC Cancer,2015,15:831.

256.Cai JB,Shi GM,Dong ZR,Ke AW,Ma HH,Gao Q,Shen ZZ,Huang XY,Chen H,Yu DD,Liu LX,Zhang PF,Zhang C,Hu MY,Yang LX,Shi YH,Wang XY,Ding ZB,Qiu SJ,Sun HC,Zhou J,Shi YG,Fan J.Ubiquitin-specific protease 7 accelerates p14(ARF)degradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression.Hepatology,2015,61:1603-1614.

257.Chai ZT,Zhu XD,Ao JY,Wang WQ,Gao DM,Kong J,Zhang N,Zhang YY,Ye BG,Ma DN,Cai H,Sun HC.microRNA-26a suppresses recruitment of macrophages by downregulating macrophage colony-stimulating factor expression through the PI3K/Akt pathway in hepatocellular carcinoma.J Hematol Oncol,2015,8:56.

258.Chen Q,Dai Z,Yin D,Yang LX,Wang Z,Xiao YS,Fan J,Zhou J.Negative impact of preoperative platelet-lymphocyte ratio on outcome after hepatic resection for intrahepatic cholangiocarcinoma.Medicine(Baltimore),2015,94:e574.

259.Chen Q,Yang LX,Li XD,Yin D,Shi SM,Chen EB,Yu L,Zhou ZJ,Zhou SL,Shi YH,Fan J,Zhou J,Dai Z.The elevated preoperative neutrophil-to-lymphocyte ratio predicts poor prognosis in intrahepatic cholangiocarcinoma patients undergoing hepatectomy.Tumour Biol,2015,36:5283-5289.

260.Chen Z,Lu X,Wang Z,Jin G,Wang Q,Chen D,Chen T,Li J,Fan J,Cong W,Gao Q,He X.Co-expression of PKM2 and TRIM35 predicts survival and recurrence in hepatocellular carcinoma.Oncotarget,2015,6:2538-2548.

261.Dong H,Zhang L,Qian Z,Zhu X,Zhu G,Chen Y,Xie X,Ye Q,Zang J,Ren Z,Ji Q.Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma.PLoS One,2015,10:e0123175.

262.Dong L,Tan Q,Ye W,Liu D,Chen H,Hu H,Wen D,Liu Y,Cao Y,Kang J,Fan J,Guo W,Wu W.Screening and Identifying a Novel ssDNA Aptamer against Alpha-fetoprotein Using CE-SELEX.Sci Rep,2015,5:15552.

263.Dong ZR,Zhang C,Cai JB,Zhang PF,Shi GM,Gao DM,Sun HC,Qiu SJ,Zhou J,Ke AW,Fan J.Role of 5-hydroxymethylcytosine level in diagnosis and prognosis prediction of intrahepatic cholangiocarcinoma.Tumour Biol,2015,36:2763-2771.

264.Duan M,Wang ZC,Wang XY,Shi JY,Yang LX,Ding ZB,Gao Q,Zhou J,Fan J.TREM-1,an inflammatory modulator,is expressed in hepatocellular carcinoma cells and significantly promotes tumor progression.Ann Surg Oncol,2015,22:3121-3129.

265.Fu XT,Dai Z,Song K,Zhang ZJ,Zhou ZJ,Zhou SL,Zhao YM,Xiao YS,Sun QM,Ding ZB,Fan J.Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway.Int J Oncol,2015,46:587-596.

266.Gao Q,Wang XY,Zhou J,Fan J.Heterogeneity of intermediate-stage HCC necessitates personalized management including surgery.Nat Rev Clin Oncol,2015,12:10.

267.Gao Q,Wang XY,Zhou J,Fan J.Multiple carcinogenesis contributes to the heterogeneity of HCC.Nat Rev Gastroenterol Hepatol,2015,12:13.

268.Gong C,Zhang J,Zhang L,Wang Y,Ma H,Wu W,Cui J,Wang Y,Ren Z.Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma.Am J Cancer Res,2015,5:702-713.

269.Guo W,Qiu Z,Wang Z,Wang Q,Tan N,Chen T,Chen Z,Huang S,Gu J,Li J,Yao M,Zhao Y,He X.MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer.Hepatology,2015,62:1132-1144.

270.He M,Xia J,Shehab M,Wang X.The development of precision medicine in clinical practice.Clin Transl Med,2015,4:69.

271.He YF,Wang CQ,Yu Y,Qian J,Song K,Sun QM,Zhou J.Tie2-Expressing Monocytes Are Associated with Identification and Prognoses of Hepatitis B Virus Related Hepatocellular Carcinoma after Resection.PLoS One,2015,10:e0143657.

272.Hu B,Sun D,Sun C,Sun YF,Sun HX,Zhu QF,Yang XR,Gao YB,Tang WG,Fan J,Maitra A,Anders RA,Xu Y.A polymeric nanoparticle formulation of curcumin in combination with sorafenib synergistically inhibits tumor growth and metastasis in an orthotopic model of human hepatocellular carcinoma.Biochem Biophys Res Commun,2015,468:525-532.

273.Hu F,Deng X,Yang X,Jin H,Gu D,Lv X,Wang C,Zhang Y,Huo X,Shen Q,Luo Q,Zhao F,Ge T,Zhao F,Chu W,Shu H,Yao M,Fan J,Qin W.Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1alpha to promote the metastasis of hepatocellular carcinoma.Oncogene,2015,34:6007-6017.

274.Jiang K,Shang S,Li W,Guo K,Qin X,Zhang S,Liu Y.Multiple lectin assays for detecting glyco-alteration of serum GP73 in liver diseases.Glycoconj J,2015,32:657-664.

275.Jin C,Ye QH,Yuan FL,Gu YL,Li JP,Shi YH,Shen XM,Bo L,Lin ZH.Involvement of acid-sensing ion channel 1alpha in hepatic carcinoma cell migration and invasion.Tumour Biol,2015,36:4309-4317.

276.Li HJ,Sun QM,Liu LZ,Zhang J,Huang J,Wang CH,Ding R,Song K,Tong Z.High expression of IL-9R promotes the progression of human hepatocellular carcinoma and indicates a poor clinical outcome.Oncol Rep,2015,34:795-802.

277.Li JH,Xie XY,Zhang L,Le F,Ge NL,Li LX,Gan YH,Chen Y,Zhang JB,Xue TC,Chen RX,Xia JL,Zhang BH,Ye SL,Wang YH,Ren ZG.Oxaliplatin and 5-fluorouracil hepatic infusion with lipiodolized chemoembolization in large hepatocellular carcinoma.World J Gastroenterol,2015,21:3970-3977.

278.Li JH,Yao RR,Shen HJ,Zhang L,Xie XY,Chen RX,Wang YH,Ren ZG.Clostridium perfringens infection after transarterial chemoembolization for large hepatocellular carcinoma.World J Gastroenterol,2015,21:4397-4401.(https://www.daowen.com)

279.Li W,Liang Y,Yang B,Sun H,Wu W.Downregulation of ARNT2 promotes tumor growth and predicts poor prognosis in human hepatocellular carcinoma.J Gastroenterol Hepatol,2015,30:1085-1093.

280.Lin Q,Ye Q,Zhu D,Wei Y,Ren L,Zheng P,Xu P,Ye L,Lv M,Fan J,Xu J.Comparison of minimally invasive and open colorectal resections for patients undergoing simultaneous R0 resection for liver metastases:a propensity score analysis.Int J Colorectal Dis,2015,30:385-395.

281.Liu WR,Tian MX,Jin L,Yang LX,Ding ZB,Shen YH,Peng YF,Zhou J,Qiu SJ,Dai Z,Fan J,Shi YH.High levels of hepatitis B surface antigen are associated with poorer survival and early recurrence of hepatocellular carcinoma in patients with low hepatitis B viral loads.Ann Surg Oncol,2015,22:843-850.

282.Liu WR,Tian MX,Yang LX,Lin YL,Jin L,Ding ZB,Shen YH,Peng YF,Gao DM,Zhou J,Qiu SJ,Dai Z,He R,Fan J,Shi YH.PKM2 promotes metastasis by recruiting myeloidderived suppressor cells and indicates poor prognosis for hepatocellular carcinoma.Oncotarget,2015,6:846-861.

283.Liu Y,Ye X,Zhang JB,Ouyang H,Shen Z,Wu Y,Wang W,Wu J,Tao S,Yang X,Qiao K,Zhang J,Liu J,Fu Q,Xie Y.PROX1 promotes hepatocellular carcinoma proliferation and sorafenib resistance by enhancing beta-catenin expression and nuclear translocation.Oncogene,2015,34:5524-5535.

284.Ni XC,Yi Y,Fu YP,He HW,Cai XY,Wang JX,Zhou J,Cheng YF,Jin JJ,Fan J,Qiu SJ.Prognostic Value of the Modified Glasgow Prognostic Score in Patients Undergoing Radical Surgery for Hepatocellular Carcinoma.Medicine(Baltimore),2015,94:e1486.

285.Ren Z,Zhu K,Kang H,Lu M,Qu Z,Lu L,Song T,Zhou W,Wang H,Yang W,Wang X,Yang Y,Shi L,Bai Y,Guo X,Ye SL.Randomized controlled trial of the prophylactic effect of urea-based cream on sorafenib-associated hand-foot skin reactions in patients with advanced hepatocellular carcinoma.J Clin Oncol,2015,33:894-900.

286.Roessler S,Lin G,Forgues M,Budhu A,Hoover S,Simpson RM,Wu X,He P,Qin LX,Tang ZY,Ye QH,Wang XW.Integrative genomic and transcriptomic characterization of matched primary and metastatic liver and colorectal carcinoma.Int J Biol Sci,2015,11:88-98.

287.Shen Y,Shi G,Huang C,Zhu X,Chen S,Sun H,Zhou J,Fan J.Prediction of Post-Operative Liver Dysfunction by Serum Markers of Liver Fibrosis in Hepatocellular Carcinoma.PLoS One,2015,10:e0140932.

288.Shi JY,Yang LX,Wang ZC,Wang LY,Zhou J,Wang XY,Shi GM,Ding ZB,Ke AW,Dai Z,Qiu SJ,Tang QQ,Gao Q,Fan J.CC chemokine receptor-like 1 functions as a tumour suppressor by impairing CCR7-related chemotaxis in hepatocellular carcinoma.J Pathol,2015,235:546-558.

289.Song J,Ge Z,Yang X,Luo Q,Wang C,You H,Ge T,Deng Y,Lin H,Cui Y,Chu W,Yao M,Zhang Z,Gu J,Fan J,Qin W.Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin.Cancer Lett,2015,356:713-720.

290.Tang W,Feng X,Zhang S,Ren Z,Liu Y,Yang B,lv B,Cai Y,Xia J,Ge N.Caveolin-1 Confers Resistance of Hepatoma Cells to Anoikis by Activating IGF-1 Pathway.Cell Physiol Biochem,2015,36:1223-1236.

291.Tian M,Li Y,Liu W,Jin L,Jiang X,Wang X,Ding Z,Peng Y,Zhou J,Fan J,Cao Y,Wang W,Shi Y.The nanomechanical signature of liver cancer tissues and its molecular origin.Nanoscale,2015,7:12998-13010.

292.Wan J,Wen D,Dong L,Tang J,Liu D,Liu Y,Tao Z,Gao D,Sun H,Cao Y,Fan J,Wu W.Establishment of monoclonal HCC cell lines with organ site-specific tropisms.BMC Cancer,2015,15:678.

293.Wang Z,Liao BY,Qiu SJ,Sun HC,Yang XR,Zhou J,Fan J.Oxidized Regenerated Cellulose Reduces the Amount of Fluid Drainage after Liver Resection:A Randomized Prospective Clinical Trial.Hepatogastroenterology,2015,62:951-954.

294.Wang ZC,Gao Q,Shi JY,Guo WJ,Yang LX,Liu XY,Liu LZ,Ma LJ,Duan M,Zhao YJ,Wu YN,Gao DM,Wang XY,Shi GM,Ding ZB,Ke AW,Tang QQ,Cao Y,Zhou J,Fan J.Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor-induced epithelial-mesenchymal transition.Hepatology,2015,62:1201-1214.

295.Wang ZC,Liu LZ,Liu XY,Hu JJ,Wu YN,Shi JY,Yang LX,Duan M,Wang XY,Zhou J,Fan J,Gao Q.Genetic polymorphisms of the multidrug resistance 1 gene MDR1 and the risk of hepatocellular carcinoma.Tumour Biol,2015,36:7007-7015.

296.Wen D,Liu D,Tang J,Dong L,Liu Y,Tao Z,Wan J,Gao D,Wang L,Sun H,Fan J,Wu W.Malic enzyme 1 induces epithelial-mesenchymal transition and indicates poor prognosis in hepatocellular carcinoma.Tumour Biol,2015,36:6211-6221.

297.Xia J,Xu X,Huang P,He M,Wang X.The potential of CXCL5 as a target for liver cancerwhat do we know so far?Expert Opin Ther Targets,2015,19:141-146.

298.Xue T,Le F,Chen R,Xie X,Zhang L,Ge N,Chen Y,Wang Y,Zhang B,Ye S,Ren Z.Transarterial chemoembolization for huge hepatocellular carcinoma with diameter over ten centimeters:a large cohort study.Med Oncol,2015,32:64.

299.Xue TC,Jia QA,Ge NL,Chen Y,Zhang BH,Ye SL.Imbalance in systemic inflammation and immune response following transarterial chemoembolization potentially increases metastatic risk in huge hepatocellular carcinoma.Tumour Biol,2015,36:8797-8803.

300.Xue TC,Jia QA,Ge NL,Zhang BH,Wang YH,Ren ZG,Ye SL.The platelet-to-lymphocyte ratio predicts poor survival in patients with huge hepatocellular carcinoma that received transarterial chemoembolization.Tumour Biol,2015,36:6045-6051.

301.Xue TC,Zhang BH,Ye SL,Ren ZG.Differentially expressed gene profiles of intrahepatic cholangiocarcinoma,hepatocellular carcinoma,and combined hepatocellularcholangiocarcinoma by integrated microarray analysis.Tumour Biol,2015,36:5891-5899.

302.Xue TC,Zhang L,Ren ZG,Chen RX,Cui JF,Ge NL,Ye SL.Sex-determination gene SRY potentially associates with poor prognosis but not sex bias in hepatocellular carcinoma.Dig Dis Sci,2015,60:427-435.

303.Yan J,Fan Z,Wu X,Xu M,Jiang J,Tan C,Wu W,Wei X,Zhou J.Circulating tumor cells are correlated with disease progression and treatment response in an orthotopic hepatocellular carcinoma model.Cytometry A,2015,87:1020-1028.

304.Yang H,Peng YF,Ni HM,Li Y,Shi YH,Ding WX,Fan J.Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth.PLoS One,2015,10:e0130953.

305.Yang LX,Gao Q,Shi JY,Wang ZC,Zhang Y,Gao PT,Wang XY,Shi YH,Ke AW,Shi GM,Cai JB,Liu WR,Duan M,Zhao YJ,Ji Y,Gao DM,Zhu K,Zhou J,Qiu SJ,Cao Y,Tang QQ,Fan J.Mitogen-activated protein kinase kinase kinase 4 deficiency in intrahepatic cholangiocarcinoma leads to invasive growth and epithelial-mesenchymal transition.Hepatology,2015,62:1804-1816.

306.Yin X,Zhang BH,Zheng SS,Gao DM,Qiu SJ,Wu WZ,Ren ZG.Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signaling.J Hematol Oncol,2015,8:23.

307.You Y,Zheng Q,Dong Y,Wang Y,Zhang L,Xue T,Xie X,Hu C,Wang Z,Chen R,Wang Y,Cui J,Ren Z.Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin beta1/GSK3beta/beta-Catenin Signaling Pathway.PLoS One,2015,10:e0134243.

308.Zhang C,Liu LX,Dong ZR,Shi GM,Cai JB,Zhang PF,Ke AW,Yu JX,Zhou J,Fan J.Up-regulation of 14-3-3zeta expression in intrahepatic cholangiocarcinoma and its clinical implications.Tumour Biol,2015,36:1781-1789.

309.Zhang JB,Zhang B,Guo L,Lin ZH,Li XQ,Guo K,Sun HC,Ye QH.Peritumoral Cbl is a strong independent prognostic marker after curative resection of hepatocellular carcinoma.Oncotarget,2015,6:40223-40234.

310.Zhang L,Ge NL,Chen Y,Xie XY,Yin X,Gan YH,Zhang BH,Zhang JB,Chen RX,Wang YH,Ye SL,Ren ZG.Long-term outcomes and prognostic analysis of radiofrequency ablation for small hepatocellular carcinoma:10-year follow-up in Chinese patients.Med Oncol,2015,32:77.

311.Zhang P,Dong Z,Cai J,Zhang C,Shen Z,Ke A,Gao D,Fan J,Shi G.BRD4 promotes tumor growth and epithelial-mesenchymal transition in hepatocellular carcinoma.Int J Immunopathol Pharmacol,2015,28:36-44.

312.Zhang Q,Jiang K,Li Y,Gao D,Sun L,Zhang S,Liu T,Guo K,Liu Y.Histidine-rich glycoprotein function in hepatocellular carcinoma depends on its N-glycosylation status,and it regulates cell proliferation by inhibiting Erk1/2 phosphorylation.Oncotarget,2015,6:30222-30231.

313.Zhang S,Jiang K,Zhang Q,Guo K,Liu Y.Serum fucosylated paraoxonase 1 as a potential glycobiomarker for clinical diagnosis of early hepatocellular carcinoma using ELISA Index.Glycoconj J,2015,32:119-125.

314.Zhang X,Yang XR,Sun C,Hu B,Sun YF,Huang XW,Wang Z,He YF,Zeng HY,Qiu SJ,Cao Y,Fan J,Zhou J.Promyelocytic leukemia protein induces arsenic trioxide resistance through regulation of aldehyde dehydrogenase 3 family member A1 in hepatocellular carcinoma.Cancer Lett,2015,366:112-122.

315.Zhou SL,Zhou ZJ,Hu ZQ,Li X,Huang XW,Wang Z,Fan J,Dai Z,Zhou J.CXCR2/CXCL5 axis contributes to epithelial-mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3beta/Snail signaling.Cancer Lett,2015,358:124-135.

316.Zou JH,Xue TC,Sun C,Li Y,Liu BB,Sun RX,Chen J,Ren ZG,Ye SL.Prognostic significance of Hes-1,a downstream target of notch signaling in hepatocellular carcinoma.Asian Pac J Cancer Prev,2015,16:3811-3816.

317.Bai DS,Wu C,Yang LX,Zhang C,Zhang PF,He YZ,Cai JB,Song ZJ,Dong ZR,Huang XY,Ke AW,Shi GM.UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2.Oncotarget,2016,7:32946-32955.

318.Cai XY,Ni XC,Yi Y,He HW,Wang JX,Fu YP,Sun J,Zhou J,Cheng YF,Jin JJ,Fan J,Qiu SJ.Overexpression of CD39 in hepatocellular carcinoma is an independent indicator of poor outcome after radical resection.Medicine(Baltimore),2016,95:e4989.

319.Chen RX,Gan YH,Ge NL,Chen Y,Ma H,Wang Y,Zhang BH,Wang YH,Ye SL,Luo JF,Ren ZG.Comparison of transarterial chemoembolization with radiofrequency ablation for unresectable Barcelona Clinic Liver Cancer stage 0/A hepatocellular carcinoma:a propensity score matching.J Gastroenterol Hepatol,2016,31:442-449.

320.Ding ZB,Fu XT,Shi YH,Zhou J,Peng YF,Liu WR,Shi GM,Gao Q,Wang XY,Song K,Jin L,Tian MX,Shen YH,Fan J.Lamp2a is required for tumor growth and promotes tumor recurrence of hepatocellular carcinoma.Int J Oncol,2016,49:2367-2376.

321.Dong P,Ma L,Liu L,Zhao G,Zhang S,Dong L,Xue R,Chen S.CD86(+)/CD206(+),Diametrically Polarized Tumor-Associated Macrophages,Predict Hepatocellular Carcinoma Patient Prognosis.Int J Mol Sci,2016,17:320.

322.Dong Y,Shen X,He M,Wu Z,Zheng Q,Wang Y,Chen Y,Wu S,Cui J,Zeng Z.Activation of the JNK-c-Jun pathway in response to irradiation facilitates Fas ligand secretion in hepatoma cells and increases hepatocyte injury.J Exp Clin Cancer Res,2016,35:114.

323.Fan W,Li J,Wang Y,Pan J,Li S,Zhu L,Guo C,Yan Z.CD105 promotes chondrogenesis of synovium-derived mesenchymal stem cells through Smad2 signaling.Biochem Biophys Res Commun,2016,474:338-344.

324.Fang T,Hou J,He M,Wang L,Zheng M,Wang X,Xia J.Actinidia chinensis Planch root extract(ac Roots)inhibits hepatocellular carcinoma progression by inhibiting EP3 expression.Cell Biol Toxicol,2016,32:499-511.

325.Fang T,Lin J,Wang Y,Chen G,Huang J,Chen J,Zhao Y,Sun R,Liang C,Liu B.Tetraspanin-8 promotes hepatocellular carcinoma metastasis by increasing ADAM12m expression.Oncotarget,2016,7:40630-40643.

326.Fu YP,Ni XC,Yi Y,Cai XY,He HW,Wang JX,Lu ZF,Han X,Cao Y,Zhou J,Fan J,Qiu SJ.A Novel and Validated Inflammation-Based Score(IBS)Predicts Survival in Patients With Hepatocellular Carcinoma Following Curative Surgical Resection:A STROBE-Compliant Article.Medicine(Baltimore),2016,95:e2784.

327.Fu YP,Yi Y,Cai XY,Sun J,Ni XC,He HW,Wang JX,Lu ZF,Huang JL,Cao Y,Zhou J,Fan J,Qiu SJ.Overexpression of interleukin-35 associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection.Br J Cancer,2016,114:767-776.

328.Gong ZJ,Guo W,Sun YF,Zhang X,Qiu SJ,Zhou J,Fan J,Yang XR.Prognostic value of fever grade combined with neutrophil percentage in hepatocellular carcinoma patients presenting fever as the initial manifestation.Onco Targets Ther,2016,9:6281-6290.

329.Guo L,Zhang S,Zhang B,Chen W,Li X,Zhang W,Zhou C,Zhang J,Ren N,Ye Q.Silencing GTSE-1 expression inhibits proliferation and invasion of hepatocellular carcinoma cells.Cell Biol Toxicol,2016,32:263-274.

330.Huang A,Zhang X,Zhou SL,Cao Y,Huang XW,Fan J,Yang XR,Zhou J.Detecting Circulating Tumor DNA in Hepatocellular Carcinoma Patients Using Droplet Digital PCR Is Feasible and Reflects Intratumoral Heterogeneity.J Cancer,2016,7:1907-1914.

331.Huang A,Zhang X,Zhou SL,Cao Y,Huang XW,Fan J,Yang XR,Zhou J.Plasma Circulating Cell-free DNA Integrity as a Promising Biomarker for Diagnosis and Surveillance in Patients with Hepatocellular Carcinoma.J Cancer,2016,7:1798-1803.

332.Jiang K,Li W,Shang S,Sun L,Guo K,Zhang S,Liu Y.Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma.Oncol Rep,2016,35:2141-2150.

333.Jiang K,Li W,Zhang Q,Yan G,Guo K,Zhang S,Liu Y.GP73 N-glycosylation at Asn144 reduces hepatocellular carcinoma cell motility and invasiveness.Oncotarget,2016,7:23530-23541.

334.Jin L,Liu WR,Tian MX,Fan J,Shi YH.The Sph Ks/S1P/S1PR1 axis in immunity and cancer:more ore to be mined.World J Surg Oncol,2016,14:131.

335.Ke AW,Zhang PF,Shen YH,Gao PT,Dong ZR,Zhang C,Cai JB,Huang XY,Wu C,Zhang L,Kang Q,Liu LX,Xie N,Shen ZZ,Hu MY,Cao Y,Qiu SJ,Sun HC,Zhou J,Fan J,Shi GM.Generation and characterization of a tetraspanin CD151/integrin alpha6beta1-binding domain competitively binding monoclonal antibody for inhibition of tumor progression in HCC.Oncotarget,2016,7:6314-6322.

336.Li JH,Wang Y,Xie XY,Yin X,Zhang L,Chen RX,Ren ZG.Aspirin in combination with TACE in treatment of unresectable HCC:a matched-pairs analysis.Am J Cancer Res,2016,6:2109-2116.

337.Li JH,Wang YC,Qin CD,Yao RR,Zhang R,Wang Y,Xie XY,Zhang L,Wang YH,Ren ZG.Over expression of hyaluronan promotes progression of HCC via CD44-mediated pyruvate kinase M2 nuclear translocation.Am J Cancer Res,2016,6:509-521.

338.Li X,Lin Z,Zhang B,Guo L,Liu S,Li H,Zhang J,Ye Q.beta-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.Sci Rep,2016,6:21010.

339.Liu D,Dong L,Liu Y,Wen D,Gao D,Sun H,Fan J,Wu W.A c-Myc/miR-17-5p feedback loop regulates metastasis and invasion of hepatocellular carcinoma.Tumour Biol,2016,37:5039-5047.

340.Liu S,Li X,Li H,Guo L,Zhang B,Gong Z,Zhang J,Ye Q.Longer duration of the Pringle maneuver is associated with hepatocellular carcinoma recurrence following curative resection.J Surg Oncol,2016,114:112-118.

341.Liu S,Li X,Li H,Guo L,Zhang B,Zhang J,Ye Q.Is the Hong Kong Liver Cancer staging system the best guide for hepatitis B virus-related hepatocellular carcinoma patients with multiple tumors?Oncotarget,2016,7:51598-51607.

342.Liu WR,Jin L,Tian MX,Jiang XF,Yang LX,Ding ZB,Shen YH,Peng YF,Gao DM,Zhou J,Qiu SJ,Dai Z,Fan J,Shi YH.Caveolin-1 promotes tumor growth and metastasis via autophagy inhibition in hepatocellular carcinoma.Clin Res Hepatol Gastroenterol,2016,40:169-178.

343.Liu Y,Liu DL,Dong LL,Wen D,Shi DM,Zhou J,Fan J,Wu WZ.miR-612 suppresses stem cell-like property of hepatocellular carcinoma cells by modulating Sp1/Nanog signaling.Cell Death Dis,2016,7:e2377.

344.Ma DN,Chai ZT,Zhu XD,Zhang N,Zhan DH,Ye BG,Wang CH,Qin CD,Zhao YM,Zhu WP,Cao MQ,Gao DM,Sun HC,Tang ZY.MicroRNA-26a suppresses epithelialmesenchymal transition in human hepatocellular carcinoma by repressing enhancer of zeste homolog 2.J Hematol Oncol,2016,9:1.

345.Ma L,Dong P,Liu L,Gao Q,Duan M,Zhang S,Chen S,Xue R,Wang X.Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway.Biochem Biophys Res Commun,2016,473:503-510.

346.Ma XL,Gao XH,Gong ZJ,Wu J,Tian L,Zhang CY,Zhou Y,Sun YF,Hu B,Qiu SJ,Zhou J,Fan J,Guo W,Yang XR.Apolipoprotein A1:a novel serum biomarker for predicting the prognosis of hepatocellular carcinoma after curative resection.Oncotarget,2016,7:70654-70668.

347.Ma XL,Zhou JY,Gao XH,Tian L,Wu J,Zhang CY,Zhou Y,Dai Q,Wang BL,Pan BS,Yang XR,Guo W.Application of the albumin-bilirubin grade for predicting prognosis after curative resection of patients with early-stage hepatocellular carcinoma.Clin Chim Acta,2016,462:15-22.

348.Shang S,Qin X,Li W,Zhang S,Liu Y.ELISA index of serum fucosylated haptoglobin for diagnosis of HCC using the normal and reverse AAL ELISA.Discov Med,2016,21:15-23.

349.Shi JY,Xing Q,Duan M,Wang ZC,Yang LX,Zhao YJ,Wang XY,Liu Y,Deng M,Ding ZB,Ke AW,Zhou J,Fan J,Cao Y,Wang J,Xi R,Gao Q.Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity.Oncotarget,2016,7:2867-2877.

350.Xie D,Ren Z,Fan J,Gao Q.Genetic profiling of intrahepatic cholangiocarcinoma and its clinical implication in targeted therapy.Am J Cancer Res,2016,6:577-586.

351.Xue TC,Ge NL,Xu X,Le F,Zhang BH,Wang YH.High platelet counts increase metastatic risk in huge hepatocellular carcinoma undergoing transarterial chemoembolization.Hepatol Res,2016,46:1028-1036.

352.Yang H,Ni HM,Guo F,Ding Y,Shi YH,Lahiri P,Frohlich LF,Rulicke T,Smole C,Schmidt VC,Zatloukal K,Cui Y,Komatsu M,Fan J,Ding WX.Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice.J Biol Chem,2016,291:18663-18674.

353.Ye BG,Sun HC,Zhu XD,Chai ZT,Zhang YY,Ao JY,Cai H,Ma DN,Wang CH,Qin CD,Gao DM,Tang ZY.Reduced expression of CD109 in tumor-associated endothelial cells promotes tumor progression by paracrine interleukin-8 in hepatocellular carcinoma.Oncotarget,2016,7:29333-29345.

354.You Y,Zheng Q,Dong Y,Xie X,Wang Y,Wu S,Zhang L,Wang Y,Xue T,Wang Z,Chen R,Wang Y,Cui J,Ren Z.Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells.Oncotarget,2016,7:32221-32231.

355.Zhang QB,Zhang BH,Zhang KZ,Meng XT,Jia QA,Zhang QB,Bu Y,Zhu XD,Ma DN,Ye BG,Zhang N,Ren ZG,Sun HC,Tang ZY.Moderate swimming suppressed the growth and metastasis of the transplanted liver cancer in mice model:with reference to nervous system.Oncogene,2016,35:4122-4131.

356.Zhang S,Shang S,Li W,Qin X,Liu Y.Insights on N-glycosylation of human haptoglobin and its association with cancers.Glycobiology,2016,26:684-692.

357.Zhou SL,Hu ZQ,Zhou ZJ,Dai Z,Wang Z,Cao Y,Fan J,Huang XW,Zhou J.miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis.Hepatology,2016,63:1560-1575.

358.Zhou SL,Zhou ZJ,Hu ZQ,Huang XW,Wang Z,Chen EB,Fan J,Cao Y,Dai Z,Zhou J.Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib.Gastroenterology,2016,150:1646-1658,e1617.

359.Zhou Y,Wang B,Wu J,Zhang C,Zhou Y,Yang X,Zhou J,Guo W,Fan J.Association of preoperative EpCAM Circulating Tumor Cells and peripheral Treg cell levels with early recurrence of hepatocellular carcinoma following radical hepatic resection.BMC Cancer,2016,16:506.

360.Zou JH,Zhang L,Ren ZG,Ye SL.Efficacy and safety of c TACE versus DEB-TACE in patients with hepatocellular carcinoma:a meta-analysis.J Dig Dis,2016,17:510-517.

361.Ao JY,Zhu XD,Chai ZT,Cai H,Zhang YY,Zhang KZ,Kong LQ,Zhang N,Ye BG,Ma DN,Sun HC.Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma.Mol Cancer Ther,2017,16:1544-1554.

362.Cai H,Zhu XD,Ao JY,Ye BG,Zhang YY,Chai ZT,Wang CH,Shi WK,Cao MQ,Li XL,Sun HC.Colony-stimulating factor-1-induced AIF1 expression in tumor-associated macrophages enhances the progression of hepatocellular carcinoma.Oncoimmunology,2017,6:e1333213.

363.Chen EB,Zhou SL,Pang XG,Yin D,Miao PZ,Yang Y,Chen Q,Zhu K,Gao DM,Liu TS,Wang XY,Shi YH,Wu WZ,Zhou J,Zhou ZJ,Dai Z.Prostate-derived ETS factor improves prognosis and represses proliferation and invasion in hepatocellular carcinoma.Oncotarget,2017,8:52488-52500.

364.Chen GL,Ye T,Chen HL,Zhao ZY,Tang WQ,Wang LS,Xia JL.Xanthine dehydrogenase downregulation promotes TGFbeta signaling and cancer stem cell-related gene expression in hepatocellular carcinoma.Oncogenesis,2017,6:e382.

365.Chen Q,Yin D,Zhang Y,Yu L,Li XD,Zhou ZJ,Zhou SL,Gao DM,Hu J,Jin C,Wang Z,Shi YH,Cao Y,Fan J,Dai Z,Zhou J.MicroRNA-29a induces loss of 5-hydroxymethylcytosine and promotes metastasis of hepatocellular carcinoma through a TETSOCS1-MMP9 signaling axis.Cell Death Dis,2017,8:e2906.

366.Chen SY,Ma DN,Chen QD,Zhang JJ,Tian YR,Wang ZC,Cai H,Lin Y,Sun HC.Micro RNA-200a inhibits cell growth and metastasis by targeting Foxa2 in hepatocellular carcinoma.J Cancer,2017,8:617-625.

367.Chen XX,Cheng JW,Huang A,Zhang X,Wang J,Fan J,Zhou J,Yang XR.The effect of antiviral therapy on patients with hepatitis B virus-related hepatocellular carcinoma after curative resection:a systematic review and meta-analysis.Onco Targets Ther,2017,10:5363-5375.

368.Fan W,Li J,Chen J,Zhu L,Wang Y,Sun B,Hua B,Guo C,Yan Z.Aspirin inhibits the proliferation of synovium-derived mesenchymal stem cells by arresting the cell cycle in the G0/G1 phase.Am J Transl Res,2017,9:5056-5062.

369.Fu XT,Shi YH,Zhou J,Peng YF,Liu WR,Shi GM,Gao Q,Wang XY,Song K,Fan J,Ding ZB.Association of hepatitis status with surgical outcomes in patients with dual hepatitis B and C related hepatocellular carcinoma.Infect Agent Cancer,2017,12:28.

370.Fu YP,Yi Y,Huang JL,Jing CY,Sun J,Ni XC,Lu ZF,Cao Y,Zhou J,Fan J,Qiu SJ.Prognostic Nomograms Stratify Survival of Patients with Hepatocellular Carcinoma Without Portal Vein Tumor Thrombosis After Curative Resection.Oncologist,2017,22:561-569.

371.Gao Q,Wang ZC,Duan M,Lin YH,Zhou XY,Worthley DL,Wang XY,Niu G,Xia Y,Deng M,Liu LZ,Shi JY,Yang LX,Zhang S,Ding ZB,Zhou J,Liang CM,Cao Y,Xiong L,Xi R,Shi YY,Fan J.Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents.Gastroenterology,2017,152:232-242,e234.

372.Ge Z,Cheng Z,Yang X,Huo X,Wang N,Wang H,Wang C,Gu D,Zhao F,Yao M,Fan J,Qin W.Long noncoding RNA Sch LAH suppresses metastasis of hepatocellular carcinoma through interacting with fused in sarcoma.Cancer Sci,2017,108:653-662.

373.He M,Hou J,Wang L,Zheng M,Fang T,Wang X,Xia J.Actinidia chinensis Planch root extract inhibits cholesterol metabolism in hepatocellular carcinoma through upregulation of PCSK9.Oncotarget,2017,8:42136-42148.

374.He M,Zhang W,Dong Y,Wang L,Fang T,Tang W,Lv B,Chen G,Yang B,Huang P,Xia J.Pro-inflammation NF-kappaB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells.J Exp Clin Cancer Res,2017,36:15.

375.Hu J,Chen FY,Zhou KQ,Zhou C,Cao Y,Sun HC,Fan J,Zhou J,Wang Z.Intrahepatic cholangiocarcinoma patients without indications of lymph node metastasis not benefit from lymph node dissection.Oncotarget,2017,8:113817-113827.

376.Huang A,Zhao X,Yang XR,Li FQ,Zhou XL,Wu K,Zhang X,Sun QM,Cao Y,Zhu HM,Wang XD,Yang HM,Wang J,Tang ZY,Hou Y,Fan J,Zhou J.Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma.J Hepatol,2017,67:293-301.

377.Huang C,Zhu XD,Ji Y,Ding GY,Shi GM,Shen YH,Zhou J,Fan J,Sun HC.Microvascular invasion has limited clinical values in hepatocellular carcinoma patients at Barcelona Clinic Liver Cancer(BCLC)stages 0 or B.BMC Cancer,2017,17:58.

378.Jin L,Liu WR,Tian MX,Jiang XF,Wang H,Zhou PY,Ding ZB,Peng YF,Dai Z,Qiu SJ,Zhou J,Fan J,Shi YH.CCL24 contributes to HCC malignancy via RhoB-VEGFA-VEGFR2 angiogenesis pathway and indicates poor prognosis.Oncotarget,2017,8:5135-5148.

379.Jing CY,Fu YP,Shen HJ,Zheng SS,Lin JJ,Yi Y,Huang JL,Xu X,Zhang J,Zhou J,Fan J,Ren ZG,Qiu SJ,Zhang BH.Albumin to gamma-glutamyltransferase ratio as a prognostic indicator in intrahepatic cholangiocarcinoma after curative resection.Oncotarget,2017,8:13293-13303.

380.Jing CY,Fu YP,Zheng SS,Yi Y,Shen HJ,Huang JL,Xu X,Lin JJ,Zhou J,Fan J,Ren ZG,Qiu SJ,Zhang BH.Prognostic nomogram for patients with hepatocellular carcinoma underwent adjuvant transarterial chemoembolization following curative resection.Medicine(Baltimore),2017,96:e6140.

381.Kang Q,Cai JB,Dong RZ,Liu LX,Zhang C,Zhang PF,Zou H,Xie N,Zhang L,Zhang XY,Song ZJ,Dong ZR,Hu MY,Huang XY,Zhang XW,Ke AW,Shi GM.Mortalin promotes cell proliferation and epithelial mesenchymal transition of intrahepatic cholangiocarcinoma cells in vitro.J Clin Pathol,2017,70:677-683.

382.Li H,Li X,Liu S,Guo L,Zhang B,Zhang J,Ye Q.Programmed cell death-1(PD-1)checkpoint blockade in combination with a mammalian target of rapamycin inhibitor restrains hepatocellular carcinoma growth induced by hepatoma cell-intrinsic PD-1.Hepatology,2017,66:1920-1933.

383.Li X,Chen Q,Yin D,Shi S,Yu L,Zhou S,Chen E,Zhou Z,Shi Y,Fan J,Zhou J,Dai Z.Novel role of semaphorin 3A in the growth and progression of hepatocellular carcinoma.Oncol Rep,2017,37:3313-3320.

384.Liao R,Fu YP,Wang T,Deng ZG,Li DW,Fan J,Zhou J,Feng GS,Qiu SJ,Du CY.Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis B virus-related hepatocellular carcinoma:a retrospective cohort study at two centers in China.Oncotarget,2017,8:1774-1787.

385.Lin Y,Yang X,Liu W,Li B,Yin W,Shi Y,He R.Chemerin has a protective role in hepatocellular carcinoma by inhibiting the expression of IL-6 and GM-CSF and MDSC accumulation.Oncogene,2017,36:3599-3608.

386.Liu T,Liu D,Liu R,Jiang H,Yan G,Li W,Sun L,Zhang S,Liu Y,Guo K.Discovering potential serological biomarker for chronic Hepatitis B Virus-related hepatocellular carcinoma in Chinese population by MAL-associated serum glycoproteomics analysis.Sci Rep,2017,7:38918.

387.Liu T,Shang S,Li W,Qin X,Sun L,Zhang S,Liu Y.Assessment of Hepatocellular Carcinoma Metastasis Glycobiomarkers Using Advanced Quantitative N-glycoproteome Analysis.Front Physiol,2017,8:472.

388.Liu W,Hu J,Zhou K,Chen F,Wang Z,Liao B,Dai Z,Cao Y,Fan J,Zhou J.Serum exosomal miR-125b is a novel prognostic marker for hepatocellular carcinoma.Onco Targets Ther,2017,10:3843-3851.

389.Liu X,Wang Z,Zhang G,Zhu Q,Zeng H,Wang T,Gao F,Qi Z,Zhang J,Wang R.High TRAF6 Expression Is Associated With Esophageal Carcinoma Recurrence and Prompts Cancer Cell Invasion.Oncol Res,2017,25:485-493.

390.Lu Z,Liu S,Yi Y,Ni X,Wang J,Huang J,Fu Y,Cao Y,Zhou J,Fan J,Qiu S.Serum gamma-glutamyl transferase levels affect the prognosis of patients with intrahepatic cholangiocarcinoma who receive postoperative adjuvant transcatheter arterial chemoembolization:A propensity score matching study.Int J Surg,2017,37:24-28.

391.Ma LJ,Wang XY,Duan M,Liu LZ,Shi JY,Dong LQ,Yang LX,Wang ZC,Ding ZB,Ke AW,Cao Y,Zhang XM,Zhou J,Fan J,Gao Q.Telomere length variation in tumor cells and cancer-associated fibroblasts:potential biomarker for hepatocellular carcinoma.J Pathol,2017,243:407-417.

392.Peng Y,Yang H,Ye Q,Zhou H,Zheng M,Shi Y.Inhibition of peritoneal dissemination of colon cancer by hyperthermic CO2 insufflation:A novel approach to prevent intraperitoneal tumor spread.PLoS One,2017,12:e0172097.

393.Qin CD,Ma DN,Ren ZG,Zhu XD,Wang CH,Wang YC,Ye BG,Cao MQ,Gao DM,Tang ZY.Astragaloside IV inhibits metastasis in hepatoma cells through the suppression of epithelial-mesenchymal transition via the Akt/GSK-3beta/beta-catenin pathway.Oncol Rep,2017,37:1725-1735.

394.Ren N,Atyah M,Chen WY,Zhou CH.The various aspects of genetic and epigenetic toxicology:testing methods and clinical applications.J Transl Med,2017,15:110.

395.Shang S,Li W,Qin X,Zhang S,Liu Y.Aided Diagnosis of Hepatocellular Carcinoma Using Serum Fucosylated Haptoglobin Ratios.J Cancer,2017,8:887-893.

396.Shen H,Zheng S,Chen R,Jin X,Xu X,Jing C,Lin J,Zhang J,Zhang M,Zhang L,Xie X,Guo K,Ren Z,Lin S,Zhang B.Prognostic significance of serum procalcitonin in patients with unresectable hepatocellular carcinoma treated with transcatheter arterial chemoembolization:A retrospective analysis of 509 cases.Medicine(Baltimore),2017,96:e7438.

397.Shen Y,Zhou C,Zhu G,Shi G,Zhu X,Huang C,Zhou J,Fan J,Ding H,Ren N,Sun HC.Liver Stiffness Assessed by Shear Wave Elastography Predicts Postoperative Liver Failure in Patients with Hepatocellular Carcinoma.J Gastrointest Surg,2017,21:1471-1479.

398.Shi JY,Ma LJ,Zhang JW,Duan M,Ding ZB,Yang LX,Cao Y,Zhou J,Fan J,Zhang X,Zhao YJ,Wang XY,Gao Q.FOXP3 Is a HCC suppressor gene and Acts through regulating the TGF-beta/Smad2/3 signaling pathway.BMC Cancer,2017,17:648.

399.Shi S,Chen Q,Ye L,Yin D,Li X,Dai Z,He J.Prognostic value of systemic inflammation score in patients with hepatocellular carcinoma after hepatectomy.Oncotarget,2017,8:79366-79375.

400.Shu H,Li W,Shang S,Qin X,Zhang S,Liu Y.Diagnosis of AFP-negative early-stage hepatocellular carcinoma using Fuc-PON1.Discov Med,2017,23:163-168.

401.Sun L,Kong Y,Cao M,Zhou H,Li H,Cui Y,Fang F,Zhang W,Li J,Zhu X,Li Q,Song T,Zhang T.Decreased expression of acetyl-Co A synthase 2 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma.Cancer Sci,2017,108:1338-1346.

402.Tang WG,Hu B,Sun HX,Sun QM,Sun C,Fu PY,Yang ZF,Zhang X,Zhou CH,Fan J,Ren N,Xu Y.Long non-coding RNA00364 represses hepatocellular carcinoma cell proliferation via modulating p-STAT3-IFIT2 signaling axis.Oncotarget,2017,8:102006-102019.

403.Tian L,Yu Q,Gao XH,Wu J,Ma XL,Dai Q,Zhang CY,Zhou Y,Zhang YC,Pan BS,Zhou J,Fan J,Yang XR,Guo W.A new use for an old index:preoperative high-density lipoprotein predicts recurrence in patients with hepatocellular carcinoma after curative resections.Lipids Health Dis,2017,16:123.

404.Wang CH,Zhu XD,Ma DN,Sun HC,Gao DM,Zhang N,Qin CD,Zhang YY,Ye BG,Cai H,Shi WK,Cao MQ,Tang ZY.Flot2 promotes tumor growth and metastasis through modulating cell cycle and inducing epithelial-mesenchymal transition of hepatocellular carcinoma.Am J Cancer Res,2017,7:1068-1083.

405.Wang H,Liu W,Tian M,Tang Z,Jiang X,Zhou P,Ding Z,Peng Y,Dai Z,Qiu S,Zhou J,Fan J,Shi Y.Coagulopathy associated with poor prognosis in intrahepatic cholangiocarcinoma patients after curative resection.Biosci Trends,2017,11:469-474.

406.Wang WM,Xu Y,Wang YH,Sun HX,Sun YF,He YF,Zhu QF,Hu B,Zhang X,Xia JL,Qiu SJ,Zhou J,Yang XR,Fan J.HOXB7 promotes tumor progression via b FGF-induced activation of MAPK/ERK pathway and indicated poor prognosis in hepatocellular carcinoma.Oncotarget,2017,8:47121-47135.

407.Wang Z,Peng Y,Sun Q,Qu X,Tang M,Dai Y,Tang Z,Lau WY,Fan J,Zhou J.Salvage transhepatic arterial embolization after failed stage I ALPPS in a patient with a huge HCC with chronic liver disease:A case report.Int J Surg Case Rep,2017,39:131-135.

408.Wu J,Ma XL,Tian L,Zhang CY,Wang BL,Hu YY,Gao XH,Zhou Y,Shen MN,Peng YF,Pan BS,Zhou J,Fan J,Yang XR,Guo W.Serum IgG4:IgG Ratio Predicts Recurrence of Patients with Hepatocellular Carcinoma after Curative Resection.J Cancer,2017,8:1338-1346.

409.Xie N,Cai JB,Zhang L,Zhang PF,Shen YH,Yang X,Lu JC,Gao DM,Kang Q,Liu LX,Zhang C,Huang XY,Zou H,Zhang XY,Song ZJ,Sun HX,Fu BM,Ke AW,Shi GM.Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma.Cell Death Dis,2017,8:3205.

410.Xu G,Ye J,Liu XJ,Zhang NP,Zhao YM,Fan J,Liu XP,Wu J.Activation of pluripotent genes in hepatic progenitor cells in the transition of nonalcoholic steatohepatitis to premalignant lesions.Lab Invest,2017,97:1201-1217.

411.Ye J,Li TS,Xu G,Zhao YM,Zhang NP,Fan J,Wu J.JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity.Cancer Res,2017,77:5287-5300.

412.Yin X,Tang B,Li JH,Wang Y,Zhang L,Xie XY,Zhang BH,Qiu SJ,Wu WZ,Ren ZG.ID1 promotes hepatocellular carcinoma proliferation and confers chemoresistance to oxaliplatin by activating pentose phosphate pathway.J Exp Clin Cancer Res,2017,36:166.

413.Yin X,Zheng SS,Zhang L,Xie XY,Wang Y,Zhang BH,Wu W,Qiu S,Ren ZG.Identification of long noncoding RNA expression profile in oxaliplatin-resistant hepatocellular carcinoma cells.Gene,2017,596:53-88.

414.Yuan J,Liang H,Li J,Li M,Tang B,Ma H,Xie X,Yin X,Zhang L,Ren Z.Peripheral blood neutrophil count as a prognostic factor for patients with hepatocellular carcinoma treated with sorafenib.Mol Clin Oncol,2017,7:837-842.

415.Yue X,Ai J,Xu Y,Chen Y,Huang M,Yang X,Hu B,Zhang H,He C,Yang X,Tang W,Peng X,Dong L,Wang H,Fan J,Ding J,Geng M.Polymeric immunoglobulin receptor promotes tumor growth in hepatocellular carcinoma.Hepatology,2017,65:1948-1962.

416.Zhan H,Jiang J,Sun Q,Ke A,Hu J,Hu Z,Zhu K,Luo C,Ren N,Fan J,Zhou J,Huang X.Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma.Gastroenterol Res Pract,2017,2017:2029315.

417.Zhang L,Xie XY,Chen Y,Ge NL,Chen RX,Gan YH,Zhang BH,Wang YH,Ren ZG.Hepatitis B surface antigen predicts recurrence after radiofrequency ablation in patients with low hepatitis B virus loads.Medicine(Baltimore),2017,96:e9377.

418.Zhang N,Ma D,Wang L,Zhu X,Pan Q,Zhao Y,Zhu W,Zhou J,Wang L,Chai Z,Ao J,Sun H,Tang Z.Insufficient Radiofrequency Ablation Treated Hepatocellular Carcinoma Cells Promote Metastasis by Up-Regulation ITGB3.J Cancer,2017,8:3742-3754.

419.Zhang R,Ma M,Dong G,Yao RR,Li JH,Zheng QD,Dong YY,Ma H,Gao DM,Cui JF,Ren ZG,Chen RX.Increased matrix stiffness promotes tumor progression of residual hepatocellular carcinoma after insufficient heat treatment.Cancer Sci,2017,108:1778-1786.

420.Zhang R,Yao RR,Li JH,Dong G,Ma M,Zheng QD,Gao DM,Cui JF,Ren ZG,Chen RX.Activated hepatic stellate cells secrete periostin to induce stem cell-like phenotype of residual hepatocellular carcinoma cells after heat treatment.Sci Rep,2017,7:2164.

421.Zhang S,Cao X,Gao Q,Liu Y.Protein glycosylation in viral hepatitis-related HCC:Characterization of heterogeneity,biological roles,and clinical implications.Cancer Lett,2017,406:64-70.

422.Zhang S,Li W,Lu H,Liu Y.Quantification of N-glycosylation site occupancy status based on labeling/label-free strategies with LC-MS/MS.Talanta,2017,170:509-513.

423.Zheng BH,Yang LX,Sun QM,Fan HK,Duan M,Shi JY,Wang XY,Zhou J,Fan J,Ma ZY,Gao Q.A New Preoperative Prognostic System Combining CRP and CA199 For Patients with Intrahepatic Cholangiocarcinoma.Clin Transl Gastroenterol,2017,8:e118.

424.Zheng S,Jia Q,Shen H,Xu X,Ling J,Jing C,Zhang B.Treatment with the herbal formula Songyou Yin inhibits epithelial-mesenchymal transition in hepatocellular carcinoma through downregulation of TGF-beta1 expression and inhibition of the SMAD2/3 signaling pathway.Oncol Lett,2017,13:2309-2315.

425.Zheng S,Shen H,Jia Q,Jing C,Lin J,Zhang M,Zhang X,Zhang B,Liu Y.S100A6 promotes proliferation of intrahepatic cholangiocarcinoma cells via the activation of the p38/MAPK pathway.Future Oncol,2017,13:2053-2063.

426.Zhou C,Zhang W,Chen W,Yin Y,Atyah M,Liu S,Guo L,Shi Y,Ye Q,Dong Q,Ren N.Integrated Analysis of Copy Number Variations and Gene Expression Profiling in Hepatocellular carcinoma.Sci Rep,2017,7:10570.

427.Zhou PY,Tang Z,Liu WR,Tian MX,Jin L,Jiang XF,Wang H,Tao CY,Ding ZB,Peng YF,Qiu SJ,Dai Z,Zhou J,Fan J,Shi YH.Perioperative blood transfusion does not affect recurrence-free and overall survivals after curative resection for intrahepatic cholangiocarcinoma:a propensity score matching analysis.BMC Cancer,2017,17:762.

428.Atyah M,Yin YR,Zhou CH,Zhou Q,Chen WY,Dong QZ,Ren N.Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma.Aging(Albany NY),2018,10:2079-2097.

429.Cai H,Ye BG,Ao JY,Zhu XD,Zhang YY,Chai ZT,Wang CH,Sun HC.High expression of S100A12 on intratumoral stroma cells indicates poor prognosis following surgical resection of hepatocellular carcinoma.Oncol Lett,2018,16:5398-5404.

430.Cao MQ,You AB,Zhu XD,Zhang W,Zhang YY,Zhang SZ,Zhang KW,Cai H,Shi WK,Li XL,Li KS,Gao DM,Ma DN,Ye BG,Wang CH,Qin CD,Sun HC,Zhang T,Tang ZY.miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a.J Hematol Oncol,2018,11:12.

431.Chen W,Zhou C,Zhang W,Atyah M,Yin Y,Guo L,Tang W,Dong Q,Ye Q,Ren N.Association of WWOX rs9926344 polymorphism with poor prognosis of hepatocellular carcinoma.J Cancer,2018,9:1239-1247.

432.Chen XX,Yin Y,Cheng JW,Huang A,Hu B,Zhang X,Sun YF,Wang J,Wang YP,Ji Y,Qiu SJ,Fan J,Zhou J,Yang XR.BAP1 acts as a tumor suppressor in intrahepatic cholangiocarcinoma by modulating the ERK1/2 and JNK/c-Jun pathways.Cell Death Dis,2018,9:1036.

433.Dong G,Ma M,Lin X,Liu H,Gao D,Cui J,Ren Z,Chen R.Treatment-damaged hepatocellular carcinoma promotes activities of hepatic stellate cells and fibrosis through GDF15.Exp Cell Res,2018,370:468-477.

434.Dong G,Zheng QD,Ma M,Wu SF,Zhang R,Yao RR,Dong YY,Ma H,Gao DM,Ye SL,Cui JF,Ren ZG,Chen RX.Angiogenesis enhanced by treatment damage to hepatocellular carcinoma through the release of GDF15.Cancer Med,2018,7:820-830.

435.Dong L,Zhou H,Zhao M,Gao X,Liu Y,Liu D,Guo W,Hu H,Xie Q,Fan J,Lin J,Wu W.Phosphorothioate-Modified AP6131 Specifically Targets GPC3 when Used for Hepatocellular Carcinoma Cell Imaging.Mol Ther Nucleic Acids,2018,13:376-386.

436.Duan M,Hao J,Cui S,Worthley DL,Zhang S,Wang Z,Shi J,Liu L,Wang X,Ke A,Cao Y,Xi R,Zhang X,Zhou J,Fan J,Li C,Gao Q.Diverse modes of clonal evolution in HBVrelated hepatocellular carcinoma revealed by single-cell genome sequencing.Cell Res,2018,28:359-373.

437.Gan W,Yi Y,Fu Y,Huang J,Lu Z,Jing C,Fan J,Zhou J,Qiu S.Fibrinogen and Creactive protein score is a prognostic index for patients with hepatocellular carcinoma undergoing curative resection:a prognostic nomogram study.J Cancer,2018,9:148-156.

438.Gao PT,Ding GY,Yang X,Dong RZ,Hu B,Zhu XD,Cai JB,Ji Y,Shi GM,Shen YH,Zhou J,Fan J,Sun HC,Huang C.Invasive potential of hepatocellular carcinoma is enhanced by loss of selenium-binding protein 1 and subsequent upregulation of CXCR4.Am J Cancer Res,2018,8:1040-1049.

439.He S,Hu B,Li C,Lin P,Tang WG,Sun YF,Feng FY,Guo W,Li J,Xu Y,Yao QL,Zhang X,Qiu SJ,Zhou J,Fan J,Li YX,Li H,Yang XR.PDXliver:a database of liver cancer patient derived xenograft mouse models.BMC Cancer,2018,18:550.

440.Hu B,Ding GY,Fu PY,Zhu XD,Ji Y,Shi GM,Shen YH,Cai JB,Yang Z,Zhou J,Fan J,Sun HC,Kuang M,Huang C.NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells.J Hematol Oncol,2018,11:28.

441.Hu B,Tang WG,Fan J,Xu Y,Sun HX.Differentially expressed miRNAs in hepatocellular carcinoma cells under hypoxic conditions are associated with transcription and phosphorylation.Oncol Lett,2018,15:467-474.

442.Huang JL,Fu YP,Jing CY,Yi Y,Sun J,Gan W,Lu ZF,Zhou J,Fan J,Qiu SJ.A novel and validated prognostic nomogram based on liver fibrosis and tumor burden for patients with hepatocellular carcinoma after curative resection.J Surg Oncol,2018,117:625-633.

443.Jiang XF,Dai Y,Peng X,Shen YY,Su Y,Wei MM,Liu WR,Ding ZB,Zhang A,Shi YH,Ai J.SOMCL-085,a novel multi-targeted FGFR inhibitor,displays potent anticancer activity in FGFR-addicted human cancer models.Acta Pharmacol Sin,2018,39:243-250.

444.Jing CY,Fu YP,Huang JL,Zhang MX,Yi Y,Gan W,Xu X,Shen HJ,Lin JJ,Zheng SS,Zhang J,Zhou J,Fan J,Ren ZG,Qiu SJ,Zhang BH.Prognostic nomogram based on histological characteristics of fibrotic tumor stroma in patients who underwent curative resection for intrahepatic cholangiocarcinoma.Oncologist,2018,23:1482-1493.

445.Li JH,Fan WS,Wang MM,Wang YH,Ren ZG.Effects of mesenchymal stem cells on solid tumor metastasis in experimental cancer models:a systematic review and meta-analysis.J Transl Med,2018,16:113.

446.Li Z,Zhang J,Liu X,Li S,Wang Q,Di C,Hu Z,Yu T,Ding J,Li J,Yao M,Fan J,Huang S,Gao Q,Zhao Y,He X.The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.Nat Commun,2018,9:1572.

447.Ling CQ,Fan J,Lin HS,Shen F,Xu ZY,Lin LZ,Qin SK,Zhou WP,Zhai XF,Li B,Zhou QH,Chinese Integrative Therapy of Primary Liver Cancer Working G.Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine.J Integr Med,2018,16:236-248.

448.Liu GM,Li Q,Zhang PF,Shen SL,Xie WX,Chen B,Wu J,Hu WJ,Huang XY,Peng BG.Restoration of FBP1 suppressed Snail-induced epithelial to mesenchymal transition in hepatocellular carcinoma.Cell Death Dis,2018,9:1132.

449.Liu LZ,Yang LX,Zheng BH,Dong PP,Liu XY,Wang ZC,Zhou J,Fan J,Wang XY,Gao Q.CK7/CK19 index:A potential prognostic factor for postoperative intrahepatic cholangiocarcinoma patients.J Surg Oncol,2018,117:1531-1539.

450.Liu MX,Jin L,Sun SJ,Liu P,Feng X,Cheng ZL,Liu WR,Guan KL,Shi YH,Yuan HX,Xiong Y.Metabolic reprogramming by PCK1 promotes TCA cataplerosis,oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma.Oncogene,2018,37:1637-1653.

451.Liu S,Guo L,Li H,Zhang B,Sun J,Zhou C,Zhou J,Fan J,Ye Q.Postoperative adjuvant trans-arterial chemoembolization for patients with hepatocellular carcinoma and portal vein tumor thrombus.Ann Surg Oncol,2018,25:2098-2104.

452.Liu X,Wang Z,Chen Z,Liu L,Ma L,Dong L,Zhang Z,Zhang S,Yang L,Shi J,Fan J,Wang X,Gao Q.Efficacy and safety of transcatheter arterial chemoembolization and transcatheter arterial chemotherapy infusion in hepatocellular carcinoma:A systematic review and meta-analysis.Oncol Res,2018,26:231-239.

453.Liu X,Wang Z,Zhang G,Zhu Q,Zeng H,Wang T,Gao F,Qi Z,Zhang J,Wang R.Overexpression of asparaginyl endopeptidase is significant for esophageal carcinoma metastasis and predicts poor patient prognosis.Oncol Lett,2018,15:1229-1235.

454.Luo C,Yin D,Zhan H,Borjigin U,Li C,Zhou Z,Hu Z,Wang P,Sun Q,Fan J,Zhou J,Wang X,Zhou S,Huang X.microRNA-501-3p suppresses metastasis and progression of hepatocellular carcinoma through targeting LIN7A.Cell Death Dis,2018,9:535.

455.Lv B,Ma L,Tang W,Huang P,Yang B,Wang L,Chen S,Gao Q,Zhang S,Xia J.FXR acts as a metastasis suppressor in intrahepatic cholangiocarcinoma by inhibiting IL-6-induced epithelial-mesenchymal transition.Cell Physiol Biochem,2018,48:158-172.

456.Lv Y,Huang C,Xu H,Han X,Zhang L,Mao W,Ji Y,Jin D,Lou W,Xu X.Clinicopathological Characteristics of the primary and metastatic Hepatic Neuroendocrine Tumors and the relevant Prognosis-Related Factors:A Retrospective Study of 81 Cases in a Single Chinese Center.J Cancer,2018,9:479-487.

457.Ma LJ,Feng FL,Dong LQ,Zhang Z,Duan M,Liu LZ,Shi JY,Yang LX,Wang ZC,Zhang S,Ding ZB,Ke AW,Cao Y,Zhang XM,Zhou J,Fan J,Wang XY,Gao Q.Clinical significance of PD-1/PD-Ls gene amplification and overexpression in patients with hepatocellular carcinoma.Theranostics,2018,8:5690-5702.

458.Ma XL,Jiang M,Zhao Y,Wang BL,Shen MN,Zhou Y,Zhang CY,Sun YF,Chen JW,Hu B,Gong ZJ,Zhang X,Cao Y,Pan BS,Zhou J,Fan J,Yang XR,Guo W.Application of Serum Annexin A3 in Diagnosis,Outcome Prediction and Therapeutic Response Evaluation for Patients with Hepatocellular Carcinoma.Ann Surg Oncol,2018,25:1686-1694.

459.Ma XL,Zhu J,Wu J,Tian L,Gao YY,Zhang CY,Zhou Y,Dai Q,Wang BL,Pan BS,Zhou J,Fan J,Yang XR,Guo W.Significance of PIVKA-II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus-associated hepatocellular carcinoma.Oncol Lett,2018,15:8396-8404.

460.Shi DM,Bian XY,Qin CD,Wu WZ.miR-106b-5p promotes stem cell-like properties of hepatocellular carcinoma cells by targeting PTEN via PI3K/Akt pathway.Onco Targets Ther,2018,11:571-585.

461.Shi DM,Li LX,Bian XY,Shi XJ,Lu LL,Zhou HX,Pan TJ,Zhou J,Fan J,Wu WZ.miR-296-5p suppresses EMT of hepatocellular carcinoma via attenuating NRG1/ERBB2/ERBB3 signaling.J Exp Clin Cancer Res,2018,37:294.

462.Shi WK,Zhu XD,Wang CH,Zhang YY,Cai H,Li XL,Cao MQ,Zhang SZ,Li KS,Sun HC.PFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT.Cell Death Dis,2018,9:428.

463.Sun YF,Guo W,Xu Y,Shi YH,Gong ZJ,Ji Y,Du M,Zhang X,Hu B,Huang A,Chen GG,Lai PBS,Cao Y,Qiu SJ,Zhou J,Yang XR,Fan J.Circulating Tumor Cells from Different Vascular Sites Exhibit Spatial Heterogeneity in Epithelial and Mesenchymal Composition and Distinct Clinical Significance in Hepatocellular Carcinoma.Clin Cancer Res,2018,24:547-559.

464.Tao CY,Liu WR,Jin L,Tang Z,Tian MX,Jiang XF,Wang H,Zhou PY,Fang Y,Ding ZB,Peng YF,Dai Z,Qiu SJ,Zhou J,Fan J,Shi YH.Surgical Treatment of Combined Hepatocellular-Cholangiocarcinoma is as Effective in Elderly Patients as it is in Younger Patients:A Propensity Score Matching Analysis.J Cancer,2018,9:1106-1112.

465.Tian MX,He WJ,Liu WR,Yin JC,Jin L,Tang Z,Jiang XF,Wang H,Zhou PY,Tao CY,Ding ZB,Peng YF,Dai Z,Qiu SJ,Zhou J,Fan J,Shi YH.A Novel Risk prediction Model for Patients with Combined Hepatocellular-Cholangiocarcinoma.J Cancer,2018,9:1025-1032.

466.Wang C,Jin H,Gao D,Lieftink C,Evers B,Jin G,Xue Z,Wang L,Beijersbergen RL,Qin W,Bernards R.Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer.J Hepatol,2018,69:1057-1065.

467.Wang C,Jin H,Gao D,Wang L,Evers B,Xue Z,Jin G,Lieftink C,Beijersbergen RL,Qin W,Bernards R.A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma.Cell Res,2018,28:690-692.

468.Wang L,Min Z,Wang X,Hu M,Song D,Ren Z,Cheng Y,Wang Y.Arsenic trioxide and sorafenib combination therapy for human hepatocellular carcinoma functions via up-regulation of TNF-related apoptosis-inducing ligand.Oncol Lett,2018,16:3341-3350.

469.Wang PC,Hu ZQ,Zhou SL,Zhan H,Zhou ZJ,Luo CB,Huang XW.Downregulation of MAGE family member H1 enhances hepatocellular carcinoma progression and serves as a biomarker for patient prognosis.Future Oncol,2018,14:1177-1186.

470.Wang Z,Ren Z,Chen Y,Hu J,Yang G,Yu L,Yang X,Huang A,Zhang X,Zhou S,Sun H,Wang Y,Ge N,Xu X,Tang Z,Lau W,Fan J,Wang J,Zhou J.Adjuvant transarterial chemoembolization for HBV-related hepatocellular carcinoma after resection:A Randomized Controlled Study.Clin Cancer Res,2018,24:2074-2081.

471.Wu D,Hu D,Chen H,Shi G,Fetahu IS,Wu F,Rabidou K,Fang R,Tan L,Xu S,Liu H,Argueta C,Zhang L,Mao F,Yan G,Chen J,Dong Z,Lv R,Xu Y,Wang M,Ye Y,Zhang S,Duquette D,Geng S,Yin C,Lian CG,Murphy GF,Adler GK,Garg R,Lynch L,Yang P,Li Y,Lan F,Fan J,Shi Y,Shi YG.Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.Nature,2018,559:637-641.

472.Wu S,Zheng Q,Xing X,Dong Y,Wang Y,You Y,Chen R,Hu C,Chen J,Gao D,Zhao Y,Wang Z,Xue T,Ren Z,Cui J.Matrix stiffness-upregulated LOXL2 promotes fibronectin production,MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation.J Exp Clin Cancer Res,2018,37:99.

473.Yang B,Li M,Tang W,Liu W,Zhang S,Chen L,Xia J.Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma.Nat Commun,2018,9:678.

474.Yao RR,Li JH,Zhang R,Chen RX,Wang YH.M2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway.World J Surg Oncol,2018,16:9.

475.Zhang JW,Li LX,Wu WZ,Pan TJ,Yang ZS,Yang YK.Anti-tumor effects of paeoniflorin on epithelial-to-mesenchymal transition in human colorectal cancer cells.Med Sci Monit,2018,24:6405-6413.

476.Zhang M,Zheng S,Jing C,Zhang J,Shen H,Xu X,Lin J,Zhang B.S100A11 promotes TGF-beta1-induced epithelial-mesenchymal transition through SMAD2/3 signaling pathway in intrahepatic cholangiocarcinoma.Future Oncol,2018,14:837-847.

477.Zhang MX,Gan W,Jing CY,Zheng SS,Zhang J,Shen HJ,Xu X,Lin JJ,Zhang BH,Qiu SJ.Overexpression of interleukin-35 in intrahepatic cholangiocarcinoma is a prognostic indicator after curative resection.Cancer Sci,2018,109:1195-1206.

478.Zhang R,Lin XH,Ma M,Chen J,Chen J,Gao DM,Cui JF,Chen RX.Periostin involved in the activated hepatic stellate cells-induced progression of residual hepatocellular carcinoma after sublethal heat treatment:its role and potential for therapeutic inhibition.J Transl Med,2018,16:302.

479.Zhang R,Ma M,Lin XH,Liu HH,Chen J,Chen J,Gao DM,Cui JF,Ren ZG,Chen RX.Extracellular matrix collagen I promotes the tumor progression of residual hepatocellular carcinoma after heat treatment.BMC Cancer,2018,18:901.

480.Zhang XY,Gao PT,Yang X,Cai JB,Ding GY,Zhu XD,Ji Y,Shi GM,Shen YH,Zhou J,Fan J,Sun HC,Yang LX,Huang C.Reduced selenium-binding protein 1 correlates with a poor prognosis in intrahepatic cholangiocarcinoma and promotes the cell epithelialmesenchymal transition.Am J Transl Res,2018,10:3567-3578.

481.Zhang YY,Kong LQ,Zhu XD,Cai H,Wang CH,Shi WK,Cao MQ,Li XL,Li KS,Zhang SZ,Chai ZT,Ao JY,Ye BG,Sun HC.CD31 regulates metastasis by inducing epithelialmesenchymal transition in hepatocellular carcinoma via the ITGB1-FAK-Akt signaling pathway.Cancer Lett,2018,429:29-40.

482.Zheng BH,Liu LZ,Zhang ZZ,Shi JY,Dong LQ,Tian LY,Ding ZB,Ji Y,Rao SX,Zhou J,Fan J,Wang XY,Gao Q.Radiomics score:a potential prognostic imaging feature for postoperative survival of solitary HCC patients.BMC Cancer,2018,18:1148.

483.Zhou C,Chen W,Sun J,Atyah M,Yin Y,Zhang W,Guo L,Ye Q,Dong Q,Shi Y,Ren N.Low expression of WW domain-containing oxidoreductase associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection.Cancer Med,2018.

484.Zhou J,Sun HC,Wang Z,Cong WM,Wang JH,Zeng MS,Yang JM,Bie P,Liu LX,Wen TF,Han GH,Wang MQ,Liu RB,Lu LG,Ren ZG,Chen MS,Zeng ZC,Liang P,Liang CH,Chen M,Yan FH,Wang WP,Ji Y,Cheng WW,Dai CL,Jia WD,Li YM,Li YX,Liang J,Liu TS,Lv GY,Mao YL,Ren WX,Shi HC,Wang WT,Wang XY,Xing BC,Xu JM,Yang JY,Yang YF,Ye SL,Yin ZY,Zhang BH,Zhang SJ,Zhou WP,Zhu JY,Liu R,Shi YH,Xiao YS,Dai Z,Teng GJ,Cai JQ,Wang WL,Dong JH,Li Q,Shen F,Qin SK,Fan J.Guidelines for diagnosis and treatment of primary liver cancer in China(2017 edition).Liver Cancer,2018,7:235-260.

485.Zhu GQ,Sun M,Liao WT,Yu WH,Zhou SL,Zhou ZJ,Shi YH,Fan J,Zhou J,Qiu LX,Dai Z.Comparative efficacy and safety between ablative therapies or surgery for small hepatocellular carcinoma:a network meta-analysis.Expert Rev Gastroenterol Hepatol,2018,12:935-945.

486.Cai J,Chen L,Zhang Z,Zhang X,Lu X,Liu W,Shi G,Ge Y,Gao P,Yang Y,Ke A,Xiao L,Dong R,Zhu Y,Yang X,Wang J,Zhu T,Yang D,Huang X,Sui C,Qiu S,Shen F,Sun H,Zhou W,Zhou J,Nie J,Zeng C,Stroup EK,Zhang X,Chiu BC,Lau WY,He C,Wang H,Zhang W,Fan J.Genome-wide mapping of 5-hydroxymethylcytosines in circulating cellfree DNA as a non-invasive approach for early detection of hepatocellular carcinoma.Gut,2019,[Epub ahead of print].

487.Chen EB,Zhou ZJ,Xiao K,Zhu GQ,Yang Y,Wang B,Zhou SL,Chen Q,Yin D,Wang Z,Shi YH,Gao DM,Chen J,Zhao Y,Wu WZ,Fan J,Zhou J,Dai Z.The miR-561-5p/CX3CL1 signaling axis regulates pulmonary metastasis in hepatocellular carcinoma involving CX3CR1(+)natural killer cells infiltration.Theranostics,2019,9:4779-4794.

488.Chen H,Yu D,Fang R,Rabidou K,Wu D,Hu D,Jia P,Zhao Z,Wu Z,Peng J,Shi Y,Shi YG.TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer.Cell Res,2019,29:248-250.

489.Chen J,Tseng Y,Luo T,Li N,Ma L,Chen S.Prophylactic endoscopic therapy for variceal bleeding in patients with hepatocellular carcinoma.J Cancer,2019,10:3087-3093.

490.Chen R,Kong W,Gan Y,Ge N,Chen Y,Ding H,Luo J,Wang W,Ren Z.Tumour stiffness associated with tumour response to conventional transarterial chemoembolisation for hepatocellular carcinoma:preliminary findings.Clinical radiology,2019,74:814.e811-814.e817.

491.Dong G,Lin XH,Liu HH,Gao DM,Cui JF,Ren ZG,Chen RX.Intermittent hypoxia alleviates increased VEGF and pro-angiogenic potential in liver cancer cells.Oncol Lett,2019,18:1831-1839.

492.Dong RZ,Yang X,Zhang XY,Gao PT,Ke AW,Sun HC,Zhou J,Fan J,Cai JB,Shi GM.Predicting overall survival of patients with hepatocellular carcinoma using a three-category method based on DNA methylation and machine learning.J Cell Mol Med,2019,23:3369-3374.

493.Duan M,Goswami S,Shi JY,Wu LJ,Wang XY,Ma JQ,Zhang Z,Shi Y,Ma LJ,Zhang S,Xi RB,Cao Y,Zhou J,Fan J,Zhang XM,Gao Q.Activated and exhausted MAIT cells foster disease progression and indicate poor outcome in hepatocellular carcinoma.Clin Cancer Res,2019,25:3304-3316.

494.Fang T,Fang Y,Xu X,He M,Zhao Z,Huang P,Yuan F,Guo M,Yang B,Xia J.Actinidia chinensis Planch root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting epithelial-mesenchymal transition.J Ethnopharmacol,2019,231:474-485.

495.Fu PY,Hu B,Ma XL,Yang ZF,Yu MC,Sun HX,Huang A,Zhang X,Wang J,Hu ZQ,Zhou CH,Tang WG,Ning R,Xu Y,Zhou J.New insight into BIRC3:A novel prognostic indicator and a potential therapeutic target for liver cancer.Journal of cellular biochemistry,2019,120:6035-6045.

496.Fu XT,Song K,Zhou J,Shi YH,Liu WR,Shi GM,Gao Q,Wang XY,Ding ZB,Fan J.Tumor-associated macrophages modulate resistance to oxaliplatin via inducing autophagy in hepatocellular carcinoma.Cancer Cell Int,2019,19:71.

497.Gong ZJ,Cheng JW,Gao PT,Huang A,Sun YF,Zhou KQ,Hu B,Qiu SJ,Zhou J,Fan J,Yang XR.Clinical characteristics and prognostic factors of patients with intrahepatic cholangiocarcinoma with fever:A propensity score matching analysis.Oncologist,2019,24:997-1007.

498.Hu B,Cheng JW,Hu JW,Li H,Ma XL,Tang WG,Sun YF,Guo W,Huang A,Zhou KQ,Gao PT,Cao Y,Qiu SJ,Zhou J,Fan J,Yang XR.KPNA3 confers sorafenib resistance to advanced hepatocellular carcinoma via TWIST regulated epithelial-mesenchymal transition.J Cancer,2019,10:3914-3925.

499.Hu B,Li H,Guo W,Sun YF,Zhang X,Tang WG,Yang LX,Xu Y,Tang XY,Ding GH,Qiu SJ,Zhou J,Li YX,Fan J,Yang XR.Establishment of a hepatocellular carcinoma patientderived xenograft platform and its application in biomarker identification.Int J Cancer,2019.

500.Hu KS,Tang B,Yuan J,Lu SX,Li M,Chen RX,Zhang L,Ren ZG,Yin X.A new substage classification strategy for Barcelona Clinic Liver Cancer stage B patients with hepatocellular carcinoma.J Gastroenterol Hepatol,2019.

501.Huang C,Zhu XD,Shi GM,Shen YH,Ding GY,Cai JB,Zhou J,Fan J,Sun HC.Dexamethasone for postoperative hyperbilirubinemia in patients after liver resection:An openlabel,randomized controlled trial.Surgery,2019,165:534-540.

502.Huang P,Feng X,Zhao Z,Yang B,Fang T,Guo M,Xia J.p66Shc promotes HCC progression in the tumor microenvironment via STAT3 signaling.Exp Cell Res,2019,111550.

503.Jing CY,Fu YP,Yi Y,Zhang MX,Zheng SS,Huang JL,Gan W,Xu X,Lin JJ,Zhang J,Qiu SJ,Zhang BH.H HLA2 in intrahepatic cholangiocarcinoma:an immune checkpoint with prognostic significance and wider expression compared with PD-L1.Journal for immunotherapy of cancer,2019,7:77.

504.Li XL,Zhu XD,Cai H,Li Y,Zhou J,Fan J,Tang ZY,Sun HC.Postoperative alphafetoprotein response predicts tumor recurrence and survival after hepatectomy for hepatocellular carcinoma:A propensity score matching analysis.Surgery,2019,165:1161-1167.

505.Liu HT,Huang DA,Li MM,Liu HD,Guo K.HSF1:a mediator in metabolic alteration of hepatocellular carcinoma cells in cross-talking with tumor-associated macrophages.Am J Transl Res,2019,11:5054-5064.

506.Liu LZ,Zhang Z,Zheng BH,Shi Y,Duan M,Ma LJ,Wang ZC,Dong LQ,Dong PP,Shi JY,Zhang S,Ding ZB,Ke AW,Cao Y,Zhang XM,Xi R,Zhou J,Fan J,Wang XY,Gao Q.CCL15 recruits suppressive monocytes to facilitate immune escape and disease progression in hepatocellular carcinoma.Hepatology,2019,69:143-159.

507.Liu S,Li H,Guo L,Zhang B,Zhou B,Zhang W,Zhou J,Fan J,Ye Q.Tumor size affects efficacy of adjuvant transarterial chemoembolization in patients with hepatocellular carcinoma and microvascular invasion.Oncologist,2019,24:513-520.

508.Lu JC,Zeng HY,Sun QM,Meng QN,Huang XY,Zhang PF,Yang X,Peng R,Gao C,Wei CY,Shen YH,Cai JB,Dong RZ,Shi YH,Sun HC,Shi YG,Zhou J,Fan J,Ke AW,Yang LX,Shi GM.Distinct PD-L1/PD1 profiles and clinical implications in intrahepatic cholangiocarcinoma patients with different risk factors.Theranostics,2019,9:4678-4687.

509.Lv Y,Han X,Xu XF,Ji Y,Zhou YH,Sun HC,Zhou J,Fan J,Lou WH,Huang C.Risk factors affecting prognosis in metachronous liver metastases from WHO classification G1 and G2 gastroenteropancreatic neuroendocrine tumors after initial R0 surgical resection.BMC Cancer,2019,19:335.

510.Ma H,Wang X,Cai J,Dai Q,Natchiar SK,Lv R,Chen K,Lu Z,Chen H,Shi YG,Lan F,Fan J,Klaholz BP,Pan T,Shi Y,He C.N(6-)methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation.Nat Chem Biol,2019,15:88-94.

511.Ma XL,Shen MN,Hu B,Wang BL,Yang WJ,Lv LH,Wang H,Zhou Y,Jin AL,Sun YF,Zhang CY,Qiu SJ,Pan BS,Zhou J,Fan J,Yang XR,Guo W.CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110beta and predicts poor prognosis.J Hematol Oncol,2019,12:37.

512.Ma XL,Sun YF,Wang BL,Shen MN,Zhou Y,Chen JW,Hu B,Gong ZJ,Zhang X,Cao Y,Pan BS,Zhou J,Fan J,Guo W,Yang XR.Sphere-forming culture enriches liver cancer stem cells and reveals Stearoyl-Co A desaturase 1 as a potential therapeutic target.BMC Cancer,2019,19:760.

513.Miao B,Wei C,Qiao Z,Han W,Chai X,Lu J,Gao C,Dong R,Gao D,Huang C,Ke A,Zhou J,Fan J,Shi G,Lan F,Cai J.eIF3a mediates HIF1alpha-dependent glycolytic metabolism in hepatocellular carcinoma cells through translational regulation.Am J Cancer Res,2019,9:1079-1090.

514.Ni XC,Xu J,Yi Y,Fu YP,Cai XY,Liu G,Huang JL,Gan W,Qiu SJ.Inflammationnutrition score predicts prognosis of patients with resectable hepatocellular carcinoma.International journal of clinical oncology,2019,24:825-835.

515.Peng R,Zhang PF,Yang X,Wei CY,Huang XY,Cai JB,Lu JC,Gao C,Sun HX,Gao Q,Bai DS,Shi GM,Ke AW,Fan J.Overexpression of RNF38 facilitates TGF-beta signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma.J Exp Clin Cancer Res,2019,38:113.

516.Peng Y,Wang Z,Wang X,Chen F,Zhou J,Fan J,Shi Y.A novel very simple laparoscopic hepatic inflow occlusion apparatus for laparoscopic liver surgery.Surg Endosc,2019,33:145-152.

517.Sun J,Zhou C,Ma Q,Chen W,Atyah M,Yin Y,Fu P,Liu S,Hu B,Ren N,Zhou H.High GCLC level in tumor tissues is associated with poor prognosis of hepatocellular carcinoma after curative resection.J Cancer,2019,10:3333-3343.

518.Tang W,Lv B,Yang B,Chen Y,Yuan F,Ma L,Chen S,Zhang S,Xia J.TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/beta-catenin pathway.Oncogenesis,2019,8:9.

519.Tang W,Zhao Z,Wang C,Ye T,Yang B.Molecular design and optimization of hepatic cancer SLP76-derived PLCgamma1 SH3-binding peptide with the systematic N-substitution of peptide PXXP motif.Journal of molecular recognition:JMR,2019,e2806.

520.Tang W,Zhou Y,Sun D,Dong L,Xia J,Yang B.Oncogenic role of phospholipase C-gamma1 in progression of hepatocellular carcinoma.Hepatol Res,2019,49:559-569.

521.Tian M,Shi Y,Liu W,Fan J.Immunotherapy of hepatocellular carcinoma:strategies for combinatorial intervention.Science China Life sciences,2019,62:1138-1143.

522.Tian MX,Liu WR,Wang H,Zhou YF,Jin L,Jiang XF,Tao CY,Tang Z,Zhou PY,Fang Y,Qu WF,Ding ZB,Peng YF,Dai Z,Qiu SJ,Zhou J,Lau WY,Fan J,Shi YH.Tissueinfiltrating lymphocytes signature predicts survival in patients with early/intermediate stage hepatocellular carcinoma.BMC Med,2019,17:106.

523.Tian MX,Luo LP,Liu WR,Deng W,Yin JC,Jin L,Jiang XF,Zhou YF,Qu WF,Tang Z,Wang H,Tao CY,Fang Y,Qiu SJ,Zhou J,Liu JF,Fan J,Shi YH.Development and validation of a prognostic score predicting recurrence in resected combined hepatocellular cholangiocarcinoma.Cancer Manag Res,2019,11:5187-5195.

524.Tian MX,Zhou YF,Qu WF,Liu WR,Jin L,Jiang XF,Wang H,Tao CY,Zhou PY,Fang Y,Ding ZB,Peng YF,Zhou J,Fan J,Shi YH.Histopathology-based immunoscore predicts recurrence for intrahepatic cholangiocarcinoma after hepatectomy.Cancer Immunol Immunother,2019,68:1369-1378.

525.Wang Y,Yao R,Zhang L,Xie X,Chen R,Ren Z.IDO and intra-tumoral neutrophils were independent prognostic factors for overall survival for hepatocellular carcinoma.J Clin Lab Anal,2019,33:e22872.

526.Wei CY,Wang L,Zhu MX,Deng XY,Wang DH,Zhang SM,Ying JH,Yuan X,Wang Q,Xuan TF,He AQ,Qi FZ,Gu JY.TRIM44 activates the AKT/m TOR signal pathway to induce melanoma progression by stabilizing TLR4.J Exp Clin Cancer Res,2019,38:137.

527.Wei CY,Zhu MX,Lu NH,Peng R,Yang X,Zhang PF,Wang L,Gu JY.Bioinformaticsbased analysis reveals elevated MFSD12 as a key promoter of cell proliferation and a potential therapeutic target in melanoma.Oncogene,2019,38:1876-1891.

528.Wei CY,Zhu MX,Yang YW,Zhang PF,Yang X,Peng R,Gao C,Lu JC,Wang L,Deng XY,Lu NH,Qi FZ,Gu JY.Downregulation of RNF128 activates Wnt/beta-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma.J Hematol Oncol,2019,12:21.

529.Wei CY,Zhu MX,Zhang PF,Yang X,Wang L,Ying JH,Luan WJ,Chen C,Liu JQ,Zhu M,Yang YW,Feng ZH,Qi FZ,Gu JY.Elevated kindlin-2 promotes tumour progression and angiogenesis through the m TOR/VEGFA pathway in melanoma.Aging(Albany NY),2019,11:6273-6285.

530.Xie DY,Fan HK,Ren ZG,Fan J,Gao Q.Identifying clonal origin of multifocal hepatocellular carcinoma and its clinical implications.Clin Transl Gastroenterol,2019,10:e00006.

531.Yang X,Cai JB,Peng R,Wei CY,Lu JC,Gao C,Shen ZZ,Zhang PF,Huang XY,Ke AW,Shi GM,Fan J.The long noncoding RNA NORAD enhances the TGF-beta pathway to promote hepatocellular carcinoma progression by targeting miR-202-5p.J Cell Physiol,2019,234:12051-12060.

532.Yang X,Miao BS,Wei CY,Dong RZ,Gao PT,Zhang XY,Lu JC,Gao C,Wang XY,Sun HC,Zhou J,Fan J,Ke AW,Shi GM,Cai JB.Lymphoid-specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression.Cancer Sci,2019,110:2133-2144.

533.Yang Y,Chen Q,Piao HY,Wang B,Zhu GQ,Chen EB,Xiao K,Zhou ZJ,Shi GM,Shi YH,Wu WZ,Fan J,Zhou J,Dai Z.HNRNPAB-regulated lnc RNA-ELF209 inhibits the malignancy of hepatocellular carcinoma.Int J Cancer,2019,[Epub ahead of print].

534.Yu HM,Wang C,Yuan Z,Chen GL,Ye T,Yang BW.Lnc RNA NEAT1 promotes the tumorigenesis of colorectal cancer by sponging miR-193a-3p.Cell Prolif,2019,52:e12526.

535.Yuan J,Yin X,Tang B,Ma H,Zhang L,Li L,Chen R,Xie X,Ren Z.Transarterial chemoembolization(TACE)combined with sorafenib in treatment of HBV background hepatocellular carcinoma with portal vein tumor thrombus:A propensity score matching study.Biomed Res Int,2019:2141859.

536.Zhang MX,Gan W,Jing CY,Zheng SS,Yi Y,Zhang J,Xu X,Lin JJ,Zhang BH,Qiu SJ.High expression of Oct4 and Nanog predict poor prognosis in intrahepatic cholangiocarcinoma patients after curative resection.J Cancer,2019,10:1313-1324.

537.Zhang MX,Gan W,Jing CY,Zheng SS,Yi Y,Zhang J,Xu X,Lin JJ,Zhang BH,Qiu SJ.S100A11 promotes cell proliferation via P38/MAPK signaling pathway in intrahepatic cholangiocarcinoma.Mol Carcinog,2019,58:19-30.

538.Zhang PF,Wang F,Wu J,Wu Y,Huang W,Liu D,Huang XY,Zhang XM,Ke AW.LncRNA SNHG3 induces EMT and sorafenib resistance by modulating the miR-128/CD151 pathway in hepatocellular carcinoma.J Cell Physiol,2019,234:2788-2794.

539.Zhang PF,Wei CY,Huang XY,Peng R,Yang X,Lu JC,Zhang C,Gao C,Cai JB,Gao PT,Gao DM,Shi GM,Ke AW,Fan J.Circular RNA circ TRIM33-12 acts as the sponge of Micro RNA-191 to suppress hepatocellular carcinoma progression.Mol Cancer,2019,18:105.

540.Zhang R,Lin XH,Liu H H,Ma M,Chen J,Chen J,Gao DM,Cui JF,Chen RX.Activated hepatic stellate cells promote progression of post-heat residual hepatocellular carcinoma from autophagic survival to proliferation.Int J Hyperthermia,2019,36:253-263.

541.Zhang XF,Wang J,Jia HL,Zhu WW,Lu L,Ye QH,Nelson PJ,Qin Y,Gao DM,Zhou HJ,Qin LX.Core fucosylated glycan-dependent inhibitory effect of QSOX1-S on invasion and metastasis of hepatocellular carcinoma.Cell Death Discov,2019,5:84.

542.Zhang Y,Shi SM,Yang H,Yang LX,Wang Z,Li XD,Yin D,Shi YH,Cao Y,Dai Z,Zhou J,Chen Q.Systemic inflammation score predicts survival in patients with intrahepatic cholangiocarcinoma undergoing curative resection.J Cancer,2019,10:494-503.

543.Zhang Z,Ma L,Goswami S,Ma J,Zheng B,Duan M,Liu L,Zhang L,Shi J,Dong L,Sun Y,Tian L,Gao Q,Zhang X.Landscape of infiltrating B cells and their clinical significance in human hepatocellular carcinoma.Oncoimmunology,2019,8:e1571388.

544.Zhou C,Peng Y,Zhou K,Zhang L,Zhang X,Yu L,Hu J,Chen F,Qiu S,Zhou J,Fan J,Ren Z,Wang Z.Surgical resection plus radiofrequency ablation for the treatment of multifocal hepatocellular carcinoma.Hepatobiliary Surg Nutr,2019,8:19-28.

545.Zhou C,Zhang X,Peng Y,Zhou K,Hu J,Yu L,Chen F,Qiu S,Zhou J,Fan J,Zhang L,Wang Z.Surgical resection plus radiofrequency ablation versus radical surgery for hepatocellular carcinoma:A propensity score matching analysis.J Cancer,2019,10:3933-3940.

546.Zhou SL,Yin D,Hu ZQ,Luo CB,Zhou ZJ,Xin HY,Yang XR,Shi YH,Wang Z,Huang XW,Cao Y,Fan J,Zhou J.A positive feedback loop between cancer stem-like cells and tumor-associated neutrophils controls hepatocellular carcinoma progression.Hepatology,2019,[Epub ahead of print].

547.Zhou SL,Zhou ZJ,Hu ZQ,Song CL,Luo YJ,Luo CB,Xin HY,Yang XR,Shi YH,Wang Z,Huang XW,Cao Y,Fan J,Zhou J.Genomic sequencing identifies WNK2 as a driver in hepatocellular carcinoma and a risk factor for early recurrence.J Hepatol,2019,[Epub ahead of print].

548.Zhou ZJ,Xin HY,Li J,Hu ZQ,Luo CB,Zhou SL.Intratumoral plasmacytoid dendritic cells as a poor prognostic factor for hepatocellular carcinoma following curative resection.Cancer Immunol Immunother,2019,68:1223-1233.

549.Zhu GQ,Wang K,Wang B,Zhou YJ,Yang Y,Chen EB,Zhou ZJ,Zhou SL,Shi YH,Zhou J,Dai Z.Aspartate aminotransferase-to-platelet ratio index predicts prognosis of hepatocellular carcinoma after postoperative adjuvant transarterial chemoembolization.Cancer Manag Res,2019,11:63-79.

550.Zhu GQ,Yang Y,Chen EB,Wang B,Xiao K,Shi SM,Zhou ZJ,Zhou SL,Wang Z,Shi YH,Fan J,Zhou J,Liu TS,Dai Z.Development and validation of a new tumor-based gene signature predicting prognosis of HBV/HCV-included resected hepatocellular carcinoma patients.J Transl Med,2019,17:203.

551.Zhu GQ,Zhou YJ,Qiu LX,Wang B,Yang Y,Liao WT,Luo YH,Shi YH,Zhou J,Fan J,Dai Z.Prognostic alternative m RNA splicing signature in hepatocellular carcinoma:a study based on large-scale sequencing data.Carcinogenesis,2019,[Epub ahead of print].

552.Zhu HR,Yu XN,Zhang GC,Shi X,Bilegsaikhan E,Guo HY,Liu LL,Cai Y,Song GQ,Liu TT,Dong L,Janssen HLA,Weng SQ,Wu J,Shen XZ,Zhu JM.Comprehensive analysis of long noncoding RNAmessenger RNAmicroRNA coexpression network identifies cell cyclerelated lncRNA in hepatocellular carcinoma.Int J Mol Med,2019,[Epub ahead of print].

553.Zhu K,Peng Y,Hu J,Zhan H,Yang L,Gao Q,Jia H,Luo R,Dai Z,Tang Z,Fan J,Zhou J.Metadherin-PRMT5 complex enhances the metastasis of hepatocellular carcinoma through the WNT-beta-catenin signaling pathway.Carcinogenesis,2019,[Epub ahead of print].

554.Zhu M,Wei C,Lin J,Dong S,Gao D,Chen J,Zhao Y,Liu B.UHRF1 is regulated by miR-124-3p and promotes cell proliferation in intrahepatic cholangiocarcinoma.J Cell Physiol,2019,234:19875-19885.

555.Zou Y,Li S,Li Z,Song D,Zhang S,Yao Q.MiR-146a attenuates liver fibrosis by inhibiting transforming growth factor-beta1 mediated epithelial-mesenchymal transition in hepatocytes.Cellular signalling,2019,58:1-8.

556.Gao Q,Zhu H,Dong L,Shi W,Chen R,Song Z,Huang C,Li J,Dong X,Zhou Y,Liu Q,Ma L,Wang X,Zhou J,Liu Y,Boja E,Robles AI,Ma W,Wang P,Li Y,Ding L,Wen B,Zhang B,Rodriguez H,Gao D,Zhou H,Fan J.Integrated proteogenomic characterization of HBV-related hepatocellular carcinoma.Cell,2019,179(2):561-577,e22.