（五）综合治疗
对于肿瘤侵袭性强或已发生远处转移的患者，可采用综合疗法。但若诊断为MALT淋巴瘤则可能弊大于利。因此正确的组织学分型尤为重要。
PTL的治疗逐渐趋向个体化，手术疗效有限，需避免盲目扩大手术范围，而靶向治疗提高了治疗的有效性及安全性，将在今后的治疗中占有更加重要的地位。
PTL的预后与其分型和分期有关，DLBCL和MALT淋巴瘤的5年期望生存率分别为75%和96%。ⅠE～ⅣE期的5年期望生存率分别是86%、81%、64%、64%[4]。大多在4年内复发。预后不良的因素包括年龄，肿瘤的分期、分型和大小，淋巴结的受累情况，治疗方式的选择，纵隔受累情况，出现B型症状等[15]。
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