五、小结与展望
目前对椎间盘退变产生的病因病机缺乏明确的认识，动物模型是现代科学研究中的重要方法和手段，有助于阐明椎间盘退变发生的病因及机制，研究相应的治疗手段。值得注意的是，虽然上述模型均能在一定程度上模拟椎间盘退变的发生与发展，但都只是对单一因素进行研究，而在人类椎间盘退变的过程中，上述致病因素往往相互结合，致使椎间盘退变的病情复杂而多变。因此针对单一致病因素构建的椎间盘退变模型不能满足模拟人类复杂退变机制的要求，且目前尚未见能准确模拟人类椎间盘退变过程的动物模型。因此，在今后的科研中，应考虑多种机制的存在，建立多因素并存的椎间盘退变动物模型是将来椎间盘退变模型构建的方向。
（徐涛涛 阮红峰 金红婷 吴承亮）
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