Pharmacological Management

更新于 2026年10月31日 版权声明
5.Pharmacological Management

(1)Phenobarbital:

First choice for partial and generalized tonic-clonic seizures.Should not be used to treat the seizures associated with cerebral malaria

Loading dose:200mg im,stat,then start at 1mg/kg po od,building up to 3mg/kg(max 180mg)od nocte

SE's:Long Half life,respiratory depression

(2)phenytoin:

Reserve drug for tonic-clonic and partial seizures(not for absences).Start at 2.5mg/kg po od,building up to 5.0(max8.0)mg/kg po od.

SE's:very toxic drug,plasma levels should ideally be monitored.

(3)Female patient in childbearing age:

Add Folic acid,5 mg/d;Pre-conception counselling about AE's in pregnancy and while breastfeeding.

(4)Further management:

Admit until tests are done/patient 24 hours free of fits councel the patient and guardian about special risks:No swimming/hights/driving(at least 1 year after fit).

Abbreviations(https://www.daowen.com)

DDX(difficulty diagnosis):不同的诊断

LFT's(liver function test):肝功检查

SE's:副作用

PO:口服。

qd:一日1次

Dx(diagnosis):诊断

ONSET(beginning):开始

LP(lumbar puncture):腰穿

EEG:脑电图

MAX:最大剂量

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