2.2　Antioxidants

Since the levels of byproducts produced by oxidation are increased in chronic pancreatitis，CP patients can benefit from antioxidant therapy.However，the benefits of antioxidant therapy in the management of CP pain have demonstrated conflicting results.Ahmed and his colleagues（2014）analyzed 12 randomized trials on the effect of antioxidants in CP patients only to find the reported reduction in pain was small thus a strong conclusion whether antioxidants really had a pain relief effect could not be drawn.Zhou et al.（2015）performed a meta-analysis of eight trials including 573 CP patients，and results showed that the intervention of antioxidant use can significantly relieve pain，decrease the patients’need for analgesics and improve pain tolerance in CP patients（Rustag and Njei 2015）.Maziar et al.（Gooshe et al.2015）concluded while there was some evidence to support the pain relieving therapy of antioxidant in AP，its effect on CP and PEP was still doubtful.Recently，Talukdar et al.（2016）carried out a trial with a combination of antioxidant and pregabalin and suggested that the compound exerted significant pain relief effect.Given these controversy in the effect of antioxidants，high quality trials are still needed.(https://www.daowen.com)