PREFACE

Immunotherapy, which involves or uses components of the immune system, is the most promising therapy used to treat tumor patients.By re-awakening and enhancing the immune system to fight tumor, immunotherapy has achieved impressive clinical responses.However, many tumor types still do not respond to immunotherapy and many patients do not receive durable benefit, eventually developing resistance.

Broadening the clinical applicability of tumor immunotherapy requires a deep understanding of the molecular and genetic mechanisms that influence whether tumor cells resist or respond.With the goal of expanding the benefits of immunotherapy and finding actionable strategies to combat therapeutic resistance, an increasing number of studies have been conducting in pre-clinical and clinical models.Furthermore, significant efforts are underway to identify reliable predictive biomarkers of response and resistance to immunotherapy, such as checkpoint inhibitors.

This textbook describes the latest advancement of tumor immunotherapy: basic and clinical applications, and is specified for foreign language teaching of postgraduate students in colleges and universities who major in medical immunology.Meanwhile, this textbook describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells.The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated through both experimental clinical trials and review of current standard of tumor therapeutic agents.This information will be invaluable to both students of immunology and cancer research and practicing physicians who have patients with tumor.The textbook provides a comprehensive overview of the field, demonstrates how advances in basic immunology can and are being applied to cancer treatment, and describes the current status of approved immunotherapy regimens.

In the compiling course of the textbook, we collected and referred large numbers of the latest peer-reviewed research articles and papers in professional journals.We would very like to express our gratitude for the authors of the references.

The textbook is granted by Graduate School of Southwest Jiaotong University, and the publication is strongly supported by Southwest Jiaotong University Press.We own our special thanks to the team of Southwest Jiaotong University Press.We also acknowledge the postgraduate students Tong Gao, Qianhong Cen and Bowen Xie who helped collect the references.

Han Lei(https://www.daowen.com)

The way to contact us:

E-mail: hlei@swjtu.eud.cn

Tel: (86-28) 87634255

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