肿瘤免疫治疗概论（英文）_基础医学

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PREFACE

Immunotherapy, which involves or uses components of the immune system, is the mo...

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Chapter 1　Introduction

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1.1　Basics of the Human Immune System

The human immune is extremely complex.It has evolved over hundreds of millions o...

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1.1.1　The Phagocytes

Phagocytes are the soldiers of the immune system, and provide innate immunity.Th...

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1.1.2　The Complement System

The complement provides innate immunity.It is comprised of a collection of prote...

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1.1.3　Acquired Immunity

The acquired immunity system comprises B Cells and T Cells.Together, these cells...

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1.2　Conception of Tumor Immunotherapy

Tumor is a leading cause of mortality worldwide, accounting for one in seven dea...

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1.3　Progress of Tumor Immunotherapy

Currently, two major revolutions in tumor research and treatment are fulfilling ...

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1.3.1　Progress of Target Tumor Cells

Chimeric antigen receptor (CAR) is the core component of CAR-T, which endows T c...

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1.3.2　Progress of Activated Immune Cells [17]

A lot of studies have shown that self-antigen or tumor antigen-specific CD4+ and...

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1.4　Clinical Progress in Tumor Immunotherapy

Immunotherapy is now widely established as a potent and effective treatment opti...

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References

[1] ZAVALA V A, KALERGIS A M.New clinical advances in immunotherapy for the trea...

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Chapter 2　Biomarker of Tumor

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2.1　Conception of Biomarker in Tumor

An ideal tumor biomarker would be expected to have high sensitivity and specific...

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2.2　Role of Biomarker in Tumor

Advancement in cancer biomarker research parallel the development of technologie...

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2.2.1　Prediction of Tumor Risk

Mass spectrometry has been invaluable for the growth of proteomics, although det...

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2.2.2　Tumor Diagnosis

Biopsy: A piece of tissue is removed to be examined under a microscope to determ...

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2.2.3　Prediction of Treatment and Post-treatment

Altered protein levels, abnormal structural conformation and impaired function a...

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2.2.4　Monitoring Tumor Recurrence

Genomic analysis has established that numerous, variable mutations exert a compo...

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2.3　Biomarker of Tumor in Immunotherapy

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2.3.1　PD-L1

As one of the major threats to public health worldwide, cancer is responsible fo...

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2.3.2　Tumor Mutation Burden

Tumor has been described as a genomic disease driven by an accumulation of both ...

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2.3.3　Mismatch Repair

Mismatched nucleotides in DNA can result from polymerase misincorporation errors...

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2.3.4　Microsatellite Instability

Microsatellites (MS) are tandem repeats of short DNA sequences, abundant through...

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2.3.5　Microbiome

Humans encounter their initial gut microbiota in very early life with most studi...

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References

[1] VIRJI M A, MERCER D W, HERBERMAN R B.Tumor markers in cancer diagnosis and p...

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Chapter 3　Therapeutic Antibody

Antibodies are glycoproteins of the immunoglobulin superfamily.Antibodies are pr...

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3.1　Target Immune Cells

Over the last 20 years, major improvements have been made in the design and prod...

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3.1.1　Antagonistic Antibodies: Blocking the Suppre...

Because of the positive results obtained in murine tumor models, academic teams,...

《肿瘤免疫治疗概论（英文）》简介

PREFACE

目录

Chapter 1　Introduction

1.1　Basics of the Human Immune System

1.1.1　The Phagocytes

1.1.2　The Complement System

1.1.3　Acquired Immunity

1.2　Conception of Tumor Immunotherapy

1.3　Progress of Tumor Immunotherapy

1.3.1　Progress of Target Tumor Cells

1.3.2　Progress of Activated Immune Cells [17]

1.4　Clinical Progress in Tumor Immunotherapy

References

Chapter 2　Biomarker of Tumor

2.1　Conception of Biomarker in Tumor

2.2　Role of Biomarker in Tumor

2.2.1　Prediction of Tumor Risk

2.2.2　Tumor Diagnosis

2.2.3　Prediction of Treatment and Post-treatment

2.2.4　Monitoring Tumor Recurrence

2.3　Biomarker of Tumor in Immunotherapy

2.3.1　PD-L1

2.3.2　Tumor Mutation Burden

2.3.3　Mismatch Repair

2.3.4　Microsatellite Instability

2.3.5　Microbiome

References

Chapter 3　Therapeutic Antibody

3.1　Target Immune Cells

3.1.1　Antagonistic Antibodies: Blocking the Suppre...

《肿瘤免疫治疗概论（英文）》简介

PREFACE

目录

Chapter 1 Introduction

1.1 Basics of the Human Immune System

1.1.1 The Phagocytes

1.1.2 The Complement System

1.1.3 Acquired Immunity

1.2 Conception of Tumor Immunotherapy

1.3 Progress of Tumor Immunotherapy

1.3.1 Progress of Target Tumor Cells

1.3.2 Progress of Activated Immune Cells [17]

1.4 Clinical Progress in Tumor Immunotherapy

References

Chapter 2 Biomarker of Tumor

2.1 Conception of Biomarker in Tumor

2.2 Role of Biomarker in Tumor

2.2.1 Prediction of Tumor Risk

2.2.2 Tumor Diagnosis

2.2.3 Prediction of Treatment and Post-treatment

2.2.4 Monitoring Tumor Recurrence

2.3 Biomarker of Tumor in Immunotherapy

2.3.1 PD-L1

2.3.2 Tumor Mutation Burden

2.3.3 Mismatch Repair

2.3.4 Microsatellite Instability

2.3.5 Microbiome

References

Chapter 3 Therapeutic Antibody

3.1 Target Immune Cells

3.1.1 Antagonistic Antibodies: Blocking the Suppre...

Chapter 1　Introduction

1.1　Basics of the Human Immune System

1.1.1　The Phagocytes

1.1.2　The Complement System

1.1.3　Acquired Immunity

1.2　Conception of Tumor Immunotherapy

1.3　Progress of Tumor Immunotherapy

1.3.1　Progress of Target Tumor Cells

1.3.2　Progress of Activated Immune Cells [17]

1.4　Clinical Progress in Tumor Immunotherapy

Chapter 2　Biomarker of Tumor

2.1　Conception of Biomarker in Tumor

2.2　Role of Biomarker in Tumor

2.2.1　Prediction of Tumor Risk

2.2.2　Tumor Diagnosis

2.2.3　Prediction of Treatment and Post-treatment

2.2.4　Monitoring Tumor Recurrence

2.3　Biomarker of Tumor in Immunotherapy

2.3.1　PD-L1

2.3.2　Tumor Mutation Burden

2.3.3　Mismatch Repair

2.3.4　Microsatellite Instability

2.3.5　Microbiome

Chapter 3　Therapeutic Antibody

3.1　Target Immune Cells

3.1.1　Antagonistic Antibodies: Blocking the Suppre...