6.2.1　CD8+ T Cells

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CD8+ T cells are a crucial component of antitumor immunity, as tumor antigen-specific cytotoxic T lymphocytes can directly kill target cells by releasing granules including membrane-lytic materials such as perforin and granzymes in acquired immune responses, thereby playing a central role in antitumor immunity.Indeed, a high frequency of CD8+ T cells infiltrating cancer tissue can be a favorable prognostic indicator in ovarian cancer and colorectal cancer [37].