7.3.1　Alum

Alum was reported in the 1920’s by Glenny et al.as an enhancer of the immune responses.Today,most subcutaneous allergen-specific immunotherapy is performed with Al(OH)3 as the adjuvant,and can generally be regarded as safe in terms of acute local or systemic side effects.However,several reports of chronic aluminum toxicity are accumulating and are being inspected by national authorities [12, 13].(https://www.daowen.com)