参考文献

参考文献

[1]Weatherbee B a T,Cui T,Zernicka-Goetz M.Modeling human embryo development with embryonic and extra-embryonic stem cells.Dev Biol,2021,474:91-99.

[2]Wilcox A J,Baird D D,Weinberg C R.Time of implantation of the conceptus and loss of pregnancy.N Engl J Med,1999,340(23):1796-1799.

[3]Macklon N S,Geraedts J P,Fauser B C.Conception to ongoing pregnancy:the“black box”of early pregnancy loss.Hum Reprod Update,2002,8(4):333-343.

[4]Koot Y E,Teklenburg G,Salker M S,et al.Molecular aspects of implantation failure.Biochim Biophys Acta,2012,1822(12):1943-1950.

[5]Buster J E.Clinical Gynecologic Endocrinology and Infertility.7th ed.Philadelphia:Lippincott Williams&Wilkins,2005.

[6]Thornhill A R,Dedie-Smulders C E,Geraedts J P,et al.ESHRE PGD consortium“best practice guidelines for clinical preimplantation genetic diagnosis(PGD)and preimplantation genetic screening(PGS)”.Hum Reprod,2005,20(1):35-48.

[7]Fu J,Warmflash A,Lutolf M P.Stem-cell-based embryo models for fundamental research and translation.Nat Mater,2021,20(2):132-144.

[8]Ai Z,Yin Y,Niu B,et al.Deconstructing human peri-implantation embryogenesis based on embryos and embryoids.Biol Reprod,2022,107(1):212-225.

[9]Shahbazi M N,Siggia E D,Zernicka-Goetz M.Self-organization of stem cells into embryos:A window on early mammalian development.Science,2019,364(6444):948-951.

[10]Johnson M H,Ziomek C A.The foundation of two distinct cell lineages within the mouse morula.Cell,1981,24(1):71-80.

[11]Johnson M H,Mcconnell J M.Lineage allocation and cell polarity during mouse embryogenesis.Semin Cell Dev Biol,2004,15(5):583-597.

[12]Maitre J L,Turlier H,Illukkumbura R,et al.Asymmetric division of contractile domains couples cell positioning and fate specification.Nature,2016,536(7616):344-348.

[13]Chan C J,Costanzo M,Ruiz-Herrero T,et al.Hydraulic control of mammalian embryo size and cell fate.Nature,2019,571(7763):112-116.

[14]Niakan K K,Eggan K.Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse.Dev Biol,2013,375(1):54-64.

[15]Linneberg-Agerholm M,Wong Y F,Romero Herrera J A,et al.Naive human pluripotent stem cells respond to Wnt,Nodal and LIF signalling to produce expandable naive extra-embryonic endoderm.Development,2019,146(24).

[16]Meistermann D,Bruneau A,Loubersac S,et al.Integrated pseudotime analysis of human preimplantation embryo single-cell transcriptomes reveals the dynamics of lineage specification.Cell Stem Cell,2021.

[17]Christodoulou N,Weberling A,Strathdee D,et al.Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation.Nature communications,2019,10(1):3557.

[18]Christodoulou N,Kyprianou C,Weberling A,et al.Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation.Nat Cell Biol,2018,20(11):1278-1289.

[19]Saykali B,Mathiah N,Nahaboo W,et al.Distinct mesoderm migration phenotypes in extraembryonic and embryonic regions of the early mouse embryo.Elife,2019,8.

[20]Kurimoto K,Saitou M.Epigenome regulation during germ cell specification and development from pluripotent stem cells.Curr Opin Genet Dev,2018,52:57-64.

[21]Tam P P,Loebel D A.Gene function in mouse embryogenesis:get set for gastrulation.Nat Rev Genet,2007,8(5):368-381.

[22]David G.Wilkinson S B,Bernhard G.Herrmann.Expresson pattern of the mouse T gene and its role in mesoderm formation.Nature,1990,343(15):657-659.

[23]Blakeley P,Fogarty N M,Del Valle I,et al.Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.Development,2015,142(20):3613.

[24]Yan L,Yang M,Guo H,et al.Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells.Nature structural&molecular biology,2013,20(9):1131-1139.

[25]Boroviak T,Loos R,Lombard P,et al.Lineage-specific profiling delineates the emergence and progression of naive pluripotency in mammalian embryogenesis.Dev Cell,2015,35(3):366-382.

[26]Bedzhov I,Zernicka-Goetz M.Self-organizing properties of mouse pluripotent cells initiate morphogenesis upon implantation.Cell,2014,156(5):1032-1044.

[27]Deglincerti A,Croft G F,Pietila L N,et al.Self-organization of the in vitro attached human embryo.Nature,2016,533(7602):251-254.

[28]Shahbazi M N,Jedrusik A,Vuoristo S,et al.Self-organization of the human embryo in the absence of maternal tissues.Nat Cell Biol,2016,18(6):700-708.

[29]Nakamura T,Okamoto I,Sasaki K,et al.A developmental coordinate of pluripotency among mice,monkeys and humans.Nature,2016,537(7618):57-62.

[30]Aberkane A,Essahib W,Spits C,et al.Expression of adhesion and extracellular matrix genes in human blastocysts upon attachment in a 2D co-culture system.Mol Hum Reprod,2018,24(7):375-387.

[31]Grewal S,Carver J G,Ridley A J,et al.Implantation of the human embryo requires Rac1-dependent endometrial stromal cell migration.Proc Natl Acad Sci U S A,2008,105(42):16189-16194.

[32]Xiang L,Yin Y,Zheng Y,et al.A developmental landscape of 3D-cultured human pregastrulation embryos.Nature,2020,577(7791):537-542.

[33]Xiang L,Yin Y,Zheng Y,et al.A developmental landscape of 3D-cultured human pregastrulation embryos.Nature,2019.

[34]Zhou F,Wang R,Yuan P,et al.Reconstituting the transcriptome and DNA methylome landscapes of human implantation.Nature,2019,572(7771):660-664.

[35]Niu Y,Sun N,Li C,et al.Dissecting primate early post-implantation development using longterm in vitro embryo culture.Science,2019,366(6467).

[36]Ma H,Zhai J,Wan H,et al.In vitro culture of cynomolgus monkey embryos beyond early gastrulation.Science,2019,366(6467).

[37]Fisher S J.Why is placentation abnormal in preeclampsia?.Am J Obstet Gynecol,2015,213(4 Suppl):S115-122.

[38]Enders A C,Blankenship T N,Fazleabas A T,et al.Structure of anchoring villi and the trophoblastic shell in the human,baboon and macaque placenta.Placenta,2001,22(4):284-303.

[39]Enders A C.Cytodifferentiation of trophoblast in the anchoring villi and trophoblastic shell in the first half of gestation in the macaque.Microsc Res Tech,1997,38(1-2):3-20.

[40]Blankenship T N,King B F.Developmental changes in the cell columns and trophoblastic shell of the macaque placenta:an immunohistochemical study localizing type IV collagen,laminin,fibronectin and cytokeratins.Cell Tissue Res,1993,274(3):457-466.

[41]Turco M Y,Gardner L,Kay R G,et al.Trophoblast organoids as a model for maternal-fetal interactions during human placentation.Nature,2018,564(7735):263-267.

[42]Tsang J C H,Vong J S L,Ji L,et al.Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics.Proc Natl Acad Sci U S A,2017,114(37):E7786-E7795.

[43]Vento-Tormo R,Efremova M,Botting R A,et al.Single-cell reconstruction of the early maternal-fetal interface in humans.Nature,2018,563(7731):347-353.

[44]Liu Y,Fan X,Wang R,et al.Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta.Cell Res,2018,28(8):819-832.

[45]Sasaki K,Nakamura T,Okamoto I,et al.The germ cell fate of cynomolgus monkeys is specified in the nascent amnion.Dev Cell,2016,39(2):169-185.

[46]Artzt K.Mammalian developmental genetics in the twentieth century.Genetics,2012,192(4):1151-1163.

[47]O'rahilly R,Müller F.Developmental stages in human embryos:revised and new measurements.Cells Tissues Organs,2010,192(2):73-84.

[48]Embryology H,Embryologie.G.Langman's Medical Embryology.WILLIAMS&WILKINS,1991.

[49]Coucouvanis E,Martin G R.Signals for death and survival:a two-step mechanism for cavitation in the vertebrate embryo.Cell,1995,83(2):279-287.

[50]Gu Z,Guo J,Zhai J,et al.A uterus-inspired niche drives blastocyst development to the early organogenesis.Adv Sci(Weinh),2022,9(28):e2202282.

[51]Aguilera-Castrejon A,Oldak B,Shani T,et al.Ex utero mouse embryogenesis from pregastrulation to late organogenesis.Nature,2021,593(7857):119-124.

[52]Lovell-Badge R,Anthony E,Barker R A,et al.ISSCR guidelines for stem cell research and clinical translation:The 2021 update.Stem Cell Reports,2021,16(6):1398-1408.

[53]Richardson S M,Mitchell L A,Stracquadanio G,et al.Design of a synthetic yeast genome.Science,2017,355(6329):1040-1044.

[54]Yang J,Ryan D J,Wang W,et al.Establishment of mouse expanded potential stem cells.Nature,2017,550(7676):393-397.

[55]Evans M J,Kaufman M H.Establishment in culture of pluripotential cells from mouse embryos.Nature,1981,292(5819):154-156.

[56]Takahashi K,Yamanaka S.Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.Cell,2006,126(4):663-676.

[57]Tesar P J,Chenoweth J G,Brook F A,et al.New cell lines from mouse epiblast share defining features with human embryonic stem cells.Nature,2007,448(7150):196-199.

[58]Brons I G,Smithers L E,Trotter M W,et al.Derivation of pluripotent epiblast stem cells from mammalian embryos.Nature,2007,448(7150):191-195.

[59]Tanaka S,Kunath T,Hadjantonakis A K,et al.Promotion of trophoblast stem cell proliferation by FGF4.Science,1998,282(5396):2072-2075.

[60]Niakan K K,Schrode N,Cho L T,et al.Derivation of extraembryonic endoderm stem(XEN)cells from mouse embryos and embryonic stem cells.Nat Protoc,2013,8(6):1028-1041.

[61]Desbaillets I,Ziegler U,Groscurth P,et al.Embryoid bodies:an in vitro model of mouse embryogenesis.Exp Physiol,2000,85(6):645-651.

[62]Morgani S M,Metzger J J,Nichols J,et al.Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning.Elife,2018,7.

[63]Beccari L,Moris N,Girgin M,et al.Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids.Nature,2018,562(7726):272-276.

[64]Veenvliet J V,Bolondi A,Kretzmer H,et al.Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites.Science,2020,370(6522).

[65]Brink S,Alemany A,Batenburg V V,et al.Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids.Nature,2020,579(7799):1.

[66]Kleinman H K,Philp D,Hoffman M P.Role of the extracellular matrix in morphogenesis.Current Opinion in Biotechnology,2003,14(5):526-532.

[67]B I M A,A R H.Mechanical perspectives on the anterior-posterior axis polarization of mouse implanted embryos.Mechanisms of Development,2017,144(Pt A):62-70.

[68]Rossi G.Capturing cardiogenesis in gastruloids.Cell Stem Cell,2020,28(2).(https://www.daowen.com)

[69]Xu P F,Borges R M,Fillatre J,et al.Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre.Nature communications,2021,12(1):3277.

[70]Rivron N C,Frias-Aldeguer J,Vrij E J,et al.Blastocyst-like structures generated solely from stem cells.Nature,2018,557(7703):106-111.

[71]Vrij E J,Scholte Op Reimer Y S,Frias Aldeguer J,et al.Chemically-defined induction of a primitive endoderm and epiblast-like niche supports post-implantation progression from blastoids.bio Rxiv,2019.

[72]Li R,Zhong C,Yu Y,et al.Generation of blastocyst-like structures from mouse embryonic and adult cell cultures.Cell,2019,179(3):687-702.

[73]Sozen B,Cox A L,De Jonghe J,et al.Self-organization of mouse stem cells into an extended potential blastoid.Dev Cell,2019,51(6):698-712.

[74]Ohinata Y,Endo T A,Sugishita H,et al.Establishment of mouse stem cells that can recapitulate the developmental potential of primitive endoderm.Science,2022,375(6580):574-578.

[75]Harrison S E,Sozen B,Christodoulou N,et al.Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro.Science,2017,356(6334).

[76]Sozen B,Amadei G,Cox A,et al.Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures.Nat Cell Biol,2018,20(8):979-989.

[77]Zhang S,Chen T,Chen N,et al.Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells.Nature communications,2019,10(1):496.

[78]Kunath T,Arnaud D,Uy G D,et al.Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts.Development,2005,132(7):1649-1661.

[79]Shimosato D,Shiki M,Niwa H.Extra-embryonic endoderm cells derived from ES cells induced by GATA factors acquire the character of XEN cells.BMC Dev Biol,2007,7:80.

[80]Amadei G,Lau K Y C,De Jonghe J,et al.Inducible stem-cell-derived embryos capture mouse morphogenetic events in vitro.Dev Cell,2021,56(3):366-382.

[81]Amadei G,Handford C E,Qiu C,et al.Embryo model completes gastrulation to neurulation and organogenesis.Nature,2022,610(7930):143-153.

[82]Tarazi S,Aguilera-Castrejon A,Joubran C,et al.Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.Cell,2022,185(18):3290-3306.

[83]Lau K Y C,Rubinstein H,Gantner C W,et al.Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development.Cell Stem Cell,2022,29(10):1445-1458.

[84]Thomson J A,Itskovitz-Eldor J,Shapiro S S,et al.Embryonic stem cell lines derived from human blastocysts.Science,1998,282(5391):1145-1147.

[85]Takahashi K,Tanabe K,Ohnuki M,et al.Induction of pluripotent stem cells from adult human fibroblasts by defined factors.Cell,2007,131(5):861-872.

[86]Yang Y,Liu B,Xu J,et al.Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency.Cell,2017,169(2):243-257.

[87]Gao X,Nowak-Imialek M,Chen X,et al.Establishment of porcine and human expanded potential stem cells.Nat Cell Biol,2019,21(6):687-699.

[88]Smith A.Formative pluripotency:the executive phase in a developmental continuum.Development,2017,144(3):365-373.

[89]Itskovitz-Eldor J,Schuldiner M,Karsenti D,et al.Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers.Mol Med,2000,6(2):88-95.

[90]Warmflash A,Sorre B,Etoc F,et al.A method to recapitulate early embryonic spatial patterning in human embryonic stem cells.Nat Methods,2014,11(8):847-854.

[91]Moris N,Anlas K,Van Den Brink S C,et al.An in vitro model of early anteroposterior organization during human development.Nature,2020,582(7812):410-415.

[92]Yamanaka Y,Hamidi S,Yoshioka-Kobayashi K,et al.Reconstituting human somitogenesis in vitro.Nature,2022.

[93]Miao Y,Djeffal Y,De Simone A,et al.Reconstruction and deconstruction of human somitogenesis in vitro.Nature,2022.

[94]Shao Y,Taniguchi K,Gurdziel K,et al.Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche.Nat Mater,2017,16(4):419-425.

[95]Shao Y,Taniguchi K,Townshend R F,et al.A pluripotent stem cell-based model for postimplantation human amniotic sac development.Nature communications,2017,8(1):208.

[96]Zheng Y,Xue X,Shao Y,et al.Controlled modelling of human epiblast and amnion development using stem cells.Nature,2019,573(7774):421-425.

[97]Simunovic M,Metzger J J,Etoc F,et al.A 3D model of a human epiblast reveals BMP4-driven symmetry breaking.Nat Cell Biol,2019,21(7):900-910.

[98]Simunovic M,Siggia E D,Brivanlou A H.In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells.Cell Stem Cell,2022,29(6):962-972.

[99]Kagawa H,Javali A,Khoei H H,et al.Human blastoids model blastocyst development and implantation.Nature,2022,601(7894):600-605.

[100]Yanagida A,Spindlow D,Nichols J,et al.Naive stem cell blastocyst model captures human embryo lineage segregation.Cell Stem Cell,2021,28(6):1016-1022.

[101]Yu L,Wei Y,Duan J,et al.Blastocyst-like structures generated from human pluripotent stem cells.Nature,2021,591(7851):620-626.

[102]Sozen B,Jorgensen V,Weatherbee B a T,et al.Reconstructing aspects of human embryogenesis with pluripotent stem cells.Nature communications,2021,12(1):5550.

[103]Fan Y,Min Z,Alsolami S,et al.Generation of human blastocyst-like structures from pluripotent stem cells.Cell Discov,2021,7(1):81.

[104]Liu X,Tan J P,Schroder J,et al.Modelling human blastocysts by reprogramming fibroblasts into iBlastoids.Nature,2021,591(7851):627-632.

[105]Tu Z,Bi Y,Zhu X,et al.Modeling human pregastulation development by 3D culture of blastoids generated from primed-to-naïve transitioning intermediates.Protein&Cell,2022.

[106]Bauwens C L,Peerani R,Niebruegge S,et al.Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories.Stem Cells,2010,26(9):2300-2310.

[107]Simunovic M,Brivanlou A H.Embryoids,organoids and gastruloids:new approaches to understanding embryogenesis.Development,2017,144(6):976-985.

[108]Clark A T.Human embryo implantation modelled in microfluidic channels.Nature,2019,573(7774):350-351.

[109]Etoc F,Metzger J,Ruzo A,et al.A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization.Dev Cell,2016,39(3):302-315.

[110]Yang M,Rito T,Metzger J,et al.Depletion of aneuploid cells in human embryos and gastruloids.Nat Cell Biol,2021,23(4):314-321.

[111]Minn K T,Fu Y C,He S,et al.High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures.Elife,2020,9.

[112]Luckett W P.The development of primordial and definitive amniotic cavities in early Rhesus monkey and human embryos.Am J Anat,1975,144(2):149-167.

[113]Lee G Y,Kenny P A,Lee E H,et al.Three-dimensional culture models of normal and malignant breast epithelial cells.Nat Methods,2007,4(4):359-365.

[114]Taniguchi K,Shao Y,Townshend R F,et al.Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells.Stem Cell Reports,2015,5(6):954-962.

[115]Zheng Y,Yan R Z,Sun S,et al.Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development.Cell Stem Cell,2022,29(9):1402-1419.

[116]Zheng Y,Fu J P.First complete model of the human embryo.Nature,2021,591(7851):531-532.

[117]Zhao C,Reyes A P,Schell J P,et al.Reprogrammed blastoids contain amnion-like cells but not trophectoderm.bioRxiv,2021.

[118]Pham T X A,Panda A,Kagawa H,et al.Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells.Cell Stem Cell,2022,29(9):1346-1365.

[119]Guo G,Stirparo G G,Strawbridge S E,et al.Human naive epiblast cells possess unrestricted lineage potential.Cell Stem Cell,2021,28(6):1040-1056.

[120]Io S,Kabata M,Iemura Y,et al.Capturing human trophoblast development with naive pluripotent stem cells in vitro.Cell Stem Cell,2021,28(6):1023-1039.

[121]Stirparo G G,Boroviak T,Guo G,et al.Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast.Development,2018,145(3).

[122]Guo G,Von Meyenn F,Rostovskaya M,et al.Epigenetic resetting of human pluripotency.Development,2017,144(15):2748-2763.

[123]Dong C,Fischer L A,Theunissen T W.Recent insights into the naive state of human pluripotency and its applications.Exp Cell Res,2019,385(1):111645.

[124]Gerri C,Mccarthy A,Alanis-Lobato G,et al.Initiation of a conserved trophectoderm program in human,cow and mouse embryos.Nature,2020,587(7834):443-447.

[125]Shahbazi M N,Wang T,Tao X,et al.Developmental potential of aneuploid human embryos cultured beyond implantation.Nature communications,2020,11(1):3987.

[126]Theunissen T W,Powell B E,Wang H,et al.Systematic identification of culture conditions for induction and maintenance of naive human pluripotency.Cell Stem Cell,2014,15(4):471-487.

[127]Guo G,Von Meyenn F,Santos F,et al.Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass.Stem Cell Reports,2016,6(4):437-446.

[128]Pastor W A,Chen D,Liu W,et al.Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory.Cell Stem Cell,2016,18(3):323-329.

[129]Di Stefano B,Ueda M,Sabri S,et al.Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells.Nat Methods,2018,15(9):732-740.

[130]Hurlbut J B,Hyun I,Levine A D,et al.Revisiting the Warnock rule.Nat Biotechnol,2017,35(11):1029-1042.

[131]Powell K.What's next for lab-grown human embryos?.Nature,2021,597(7874):22-24.

[132]Murry C E,Keller G.Differentiation of embryonic stem cells to clinically relevant populations:lessons from embryonic development.Cell,2008,132(4):661-680.

[133]Chhabra S,Liu L,Goh R,et al.Dissecting the dynamics of signaling events in the BMP,WNT,and NODAL cascade during self-organized fate patterning in human gastruloids.PLoS Biol,2019,17(10):e3000498.

[134]Martyn I,Kanno T Y,Ruzo A,et al.Self-organization of a human organizer by combined Wnt and Nodal signalling.Nature,2018,558(7708):132-135.

[135]Arnold S J,Robertson E J.Making a commitment:cell lineage allocation and axis patterning in the early mouse embryo.Nat Rev Mol Cell Biol,2009,10(2):91-103.