参考文献

参考文献

[1]Ahearn I M,Haigis K,Bar-Sagi D,et al.Regulating the regulator:posttranslational modification of RAS.Nature Reviews Molecular Cell Biology,2012,13:39-51.

[2]Amaral J D,Xavier J M,Steer C J,et al.The role of p53 in apoptosis.Discov Med,2010,9:145-152.

[3]Ames B N.Identifying environmental chemicals causing mutations and cancer.Science,1979,204:587-593.

[4]Balmain A,gray J,Ponder B.Thegenetics andgenomics of cancer.Naturegenetics,2003,33:238-244.

[5]Bishop J M.Cancergenes come of age.Cell,1983,32:1018-1020.

[6]Bishop J M.Viral oncogenes.Cell,1985,42:23-38.

[7]Ciriellog,Miller M L,Aksoy B A,et al.Emerging landscape of oncogenic signatures across human cancers.Naturegenetics,2013,45:1127-1133.

[8]Kadam S,Emerson B M.Mechanisms of chromatin assembly and transcription.Curr Opin Cell Biol,2002,14:262-268.

[9]Lim A Y N,Ostor A J K,Love S,et al.Systemic mastocytosis:a rare cause of osteoporosis and its response to bisphosphonate treatment.Ann Rheum Dis,2005,64:965-966.

[10]Malumbres M,Barbacid M.RAS oncogenes:the first 30 years.Nature Reviews Cancer,2003,3:459-465.

[11]Muller P A J,Vousden K H.p53 mutations in cancer.Nature Cell Biology,2013,15:2-8.

[12]Rigby P W J,Wilkie N M.Virus and cancer.Cambridge:Cambridge University Press,1985.

[13]Robberson D L,Saundersg F.Perspectives ongenes and molecular biology of cancer.New York:Ravan Press,1983.

[14]Santos E,Martin-Zanca D,Reddy E,et al.Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.Science,1984,223:661-664.

[15]Schubbert S,Shannon K,Bollagg.Hyperactive Ras in developmental disorders and cancer.Nature Reviews Cancer,2007,7:295-308.

[16]Sinn E,Muller W,Pattengale P,et al.Coexpression of MMTV/v-Ha-ras and MMTV/c-mycgenes in transgenic mice:synergistic action of oncogenes in vivo.Cell,1987,49:465-475.

[17]Sukumar S,Notario V,Martin-Zanca D,et al.Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-l locus by single point mutations.Nature,1983,306:658-661.

[18]Suva M L,et al.Epigenetic reprogramming in cancer.Science,2013,339:1567-1570.

[19]Tabin C J,Bradley S M,Bargmann C I,et al.Mechanism of activation of a human oncogene.Nature,1982,300:143-149.

[20]Velkova A,Monteiro A N.Epigenetic tumor suppression by BRCA1.Nature medicine,2011,17:1183-1185.

[21]Willisi A,Jungl E J,Wakefieldi T,et al.Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its targetgenes.Oncogene,2004,23:2330-2338.

[22]Zack T I,Schumacher S E,Carter S L,et al.Pan-cancer patterns of somatic copy number alteration.Naturegenetics,2013,45:1134-1140.