2.4　Conclusion

Study on pancreatic stone composition and its formation mechanism is ultimately able to give more intervention and treatment in early stage of CP.Noda and Tsujimoto et al.（Noda et al.1997；Tsujimoto et al.2005）found that bromhexine hydrochloride had a high affinity for the pancreas，acting directly on the mucus-producing cells and causing them to produce low-viscosity mucus.Lohse et al.（Lohse et al.1981；Noda et al.1984）observed that organic acids dissolved pancreatic stones by chelating with calcium ions.Therefore，further work is needed to identify agents that dissolve protein plugs and pancreatic stones，which may have potential to eliminate pancreatic duct obstruction to relieve pancreatitis attacks and pancreatic pain.(https://www.daowen.com)

In conclusion，the mechanisms of pancreatic stone formation are complicated，and many proteins may play a role in the protein precipitation.So far，protein plugs formation and precipitation of CaCO3 crystal are the most important two factors in pancreatic stone formation.