Experimental Models of Chronic Pancreatitis

Ali A.Aghdassi，Matthias Sendler，Julia Mayerle，and Markus M.Lerch

Chronic pancreatitis is an inflammatory disorder of the pancreatic gland.In western countries its incidence is reported to be between 4 and 13/100,000，which is somewhat lower compared to acute pancreatitis with an estimated incidence of 13-45/100,000 persons（Levy et al.2014；Yadav and Lowenfels 2013）.However，according to recent population based studies incidence rates of chronic pancreatitis have steadily increased during the last decades and showed regional differences（Yadav and Lowenfels 2013；Yadav et al.2011）.(https://www.daowen.com)

From epidemiological data and clinical experience we know that chronic pancreatitis can develop from either recurrent bouts of acute pancreatitis in which the pancreas does not recover completely from the injury to the organ.About 20-30%of patients with acute pancreatitis suffer from recurrences and about 10%develop chronic pancreatitis.The presence of continuous environmental exposure（alcohol，tobacco）or genetic risk factors favor progression to chronic pancreatitis（Yadav and Lowenfels 2013；Yadav et al.2012）.To a much lesser extent chronic pancreatitis can develop as a result of one severe attack of acute pancreatitis that leads to necrosis and fibrosis directly（Lankisch et al.2009）.