3.2　Animal Models for Chronic Pancreatitis

Experimental models for chronic pancreatitis have been established in many animal species using various techniques（Fig.5.4）.Most of them were adapted to rodents.Chronic pancreatitis models can be classified either according to their mechanism of induction，that are meant to resemble the pathophysiology in humans or based on a completely different mechanism（Aghdassi et al.2011；Lerch and Gorelick 2013），or，alternatively，according to their morphological and clinico-biochemical characteristics.The aim of this section is to introduce frequently used animal models for experimental chronic pancreatitis including their strengths and shortcomings.We also want to point out recent developments in genetic models of chronic pancreatitis that attracted increasing attention.Furthermore，we specify what kind of pathology is seen in each model and whether it can be used for assessment of either morphological or clinical characteristics of chronic pancreatitis or both.

Fig.5.4　In-vivo experimental models for chronic pancreatitis.Techniques have been applied alone or in combination(https://www.daowen.com)