Antimalarial drugs

2.1 Drugs for treatment of blood-st?age infection

The　clinical　attack　of　malaria　is　caused　by　the　merozoite　of　Plasmodium　in　the　blood　(erythrocytic　stage).　The　schizozoidal　drugs　have　an　efficacy　on　the　malaria　parasite　in　this　period.　As　a　consequence,　they　can　clear　the　parasites　from　the　blood　quickly.　Antimalarial　drugs　can　be　divided　into　strong　and　weak　according　to　their　efficacies.　The　former　has　artemisinin,　pyronaridine,　piperaquine,　naphthoquine,　mefloquine,　chloroquine,　quinine,　adipine,　amodiaquine　and　so　on.　While　the　latter　has　lumefantrine,　proguauil,　sulfonamides,　sulfones,　antibiotics　and　so　on.

2.2 Drugs mainly used to prevent relapse and transmission(https://www.daowen.com)

At　present,　only　8-aminoquinoline　drugs　can　kill　the　liver　tissue　stage　and　gametophyte　of　Plasmodium.　Primaquine　and　tafenoquine　are　currently　recommended　by　WHO　and　approved　by　FDA　in　the　United　States.　Primaquine　is　commonly　used　in　China.

2.3 Drugs mainly used for chemoprevention

The　drugs　that　inhibit　liver-stage　or　kill　asexual　blood　stages　are　compound　piperaquine　(269g　piperaquine　phosphate,　50　mg　sulfadoxine).　Piperaquine　and　chloroquine　have　inhibitory　preventive　effect　because　the　drugs　are　eliminated　slowly　from　the　body.