2.2　Preparation of XKP

We obtained XKP from Guangzhou Zhongyi Pharmaceutical Limited Company(National Medicine Approved Number：Z44020069，standard code：86900428000227).The assortment of herbs in XKP was ground into powder and 1 g of powder was then soaked in 50mL of ultrapure water with ultrasonic treatment for 1 hand subsequently heated to 80℃for 8 h.The mixture was condensed to 10mL and filtrated through a 0.22μm sterilizing filter(Millex，SLGP033RB).The filtrate was stored in a microorganism-free tube at 4℃within three days.(https://www.daowen.com)