References

References

Ardestani，A.，Lupse，B.，Kido，Y.，Leibowitz，G.，& Maedler，K.(2018).mTORC1 signaling：A double-edged sword in diabetic beta cells.Cell Metabolism，27(2)，314-331.

Bachar—Wikstrom，E.，Wikstrom，J.D.，Ariav，Y.，Tirosh，B.，Kaiser，N.，Cerasi，E.，&Leibowitz，G.(2013).Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes.Diabetes，62(4)，1227-1237.

Barlow，A.D.，& Thomas，D.C.(2015).Autophagy in diabetes：Beta—cell dysfunction，insulin resistance，and complications.DNA and Cell Biology，34(4)，252-260.

Bartolome，A.，Guillen，C.，&Benito，M.(2012).Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreaticβ-cell death.Autophagy，8(12)，1757-1768.

Biddinger，S.B.，& Kahn，C.R.(2006).From mice to men：Insights into the insulin resistance syndromes.Annual Review of Physiology，68，123-158.

Booth，L.A.，Tavallai，S.，Hamed，H.A.，Cruickshanks，N.，& Dent，P.(2014).The role of cell signalling in the crosstalk between autophagy and apoptosis.Cellular Signalling，26(3)，549-555.

Butler，A.E.，Janson，J.，Bonner-Weir，S.，Ritzel，R.，Rizza，R.A.，& Butler，P.(2003).Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.Diabetes，52(1)，102-110.

Capolupo，A.，Esposito，R.，Zampella，A.，Festa，C.，Riccio，R.，Casapullo，A.，…Monti，M.C.(2017).Determination of gymnemic acid i as a protein biosynthesis inhibitor using chemical proteomics.Journal of Natural Products，80(4)，909-915.

Ebato，C.，Uchida，T.，Arakawa，M.，Komatsu，M.，Ueno，T.，Komiya，K.，…Watada，H.(2008).Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet.Cell Metabolism，8(4)，325 332.

Florez，J.C.，Hirschhorn，J.，& Altshuler，D.(2003).The inherited basis of diabetes mellitus：Implications for the genetic analysis of complex traits.Annual Review of Genomics and Human Genetics，4，257-291.

Fushiki，T.，Kojima，A.，Imoto，T.，Inoue，K.，& Sugimoto，E.(1992).An extract of Gymnema sylvestre leaves and purified gymnemic acid inhibits glucose-stimulated gastric inhibitory peptide secretion in rats.The Journal of Nutrition，122(12)，2367-2373.

Gasbjerg，L.S.，Gabe，M.B.N.，Hartmann，B.，Christensen，M.B.，Knop，F.K.，Holst，J.J.，& Rosenkilde，M.M.(2018).Glucose-dependent insulinotropic polypeptide(GIP)receptor antagonists as anti-diabetic agents.Peptides，100，173-181.

Han，D.，Yang，B.，Olson，L.K.，Greenstein，A.，Baek，S.H.，Claycombe，K.J.，…Kim，E.K.(2010).Activation of autophagy through modulation of 5＇-AMP-activated protein kinase protects pancreatic beta-cells from high glucose.The Biochemical Journal，425(3)，541-551.

Jiang，Y.，Huang，W.，Wang，J.，Xu，Z.，He，J.，Lin，X.，…Zhang，J.(2014).Metformin plays a dual role in MIN6 pancreatic beta cell function through AMPK-dependent autophagy.International Journal of Biologi-cal Sciences，10(3)，268-277.

Joo，E.，Harada，N.，Yamane，S.，Fukushima，T.，Taura，D.，Iwasaki，K.，…Inagaki，N.(2017).Inhibition of gastric inhibitory polypeptide receptor signaling in adipose tissue reduces insulin resistance and hepatic steatosis in high-fat diet-fed mice.Diabetes，66(4)，868-879.

Kitabchi，A.E.，Umpierrez，G.E.，Miles，J.M.，& Fisher，J.N.(2009).Hyperglycemic crises in adult patients with diabetes.Diabetes Care，32(7)，1335-1343.

Klionsky，D.J.，Abdelmohsen，K.，Abe，A.，Abedin，M.J.，Abeliovich，H.，Acevedo Arozena，A.，…Zughaier，S.M.(2016).Guidelines for the use and interpretation of assays for monitoring autophagy(3rd edition).Autophagy，12(1)，1-222.

Laplante，M.，& Sabatini，D.M.(2009).mTOR signaling at a glance.Journal of Cell Science，122(20)，3589-3594.

Lee，M.S.(2014).Role of islet beta cell autophagy in the pathogenesis of diabetes.Trends in Endocrinology and Metabolism，25(12)，620-627.(https://www.daowen.com)

Li，B.，Wu，X.，Chen，H.，Zhuang，C.，Zhang，Z.，Yao，S.，…Su，Q.(2018).MiR199a-5p inhibits hepatic insulin sensitivity via suppression of ATG14-mediated autophagy.Cell Death &Disease，9(3)，405.

Lim，H.，Lim，Y.M.，Kim，K.H.，Jeon，Y.E.，Park，K.，Kim，J.，…Lee，M.S.(2018).A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes.Nature Communications，9(1)，1438.

Marasco，M.R.，&Linnemann，A.K.(2018).Beta-cell autophagy in diabetes pathogenesis.Endocrinology，159，2127-2141.

Mizushima，N.，Levine，B.，Cuervo，A.M.，& Klionsky，D.J.(2008).Autophagy fights disease through cellular self-digestion.Nature，451(7182)，1069-1075.

Ota，A.，& Ulrih，N.P.(2017).An overview of herbal products and secondary metabolites used for management of type two diabetes.Frontiers in Pharmacology，8，436.

Sanematsu，K.，Kusakabe，Y.，Shigemura，N.，Hirokawa，T.，Nakamura，S.，Imoto，T.，&Ninomiya，Y.(2014).Molecular mechanisms for sweet-suppressing effect of gymnemic acids.The Journal of Biological Chemistry，289(37)，25711-25720.

Shen，H.，Zhao，S.，Xu，Z.，Zhu，L.，Han，Y.，& Ye，J.(2015).Evodiamine inhibits proliferation and induces apoptosis in gastric cancer cells.Oncology Letters，10(1)，367-371.

Shigihara，N.，Fukunaka，A.，Hara，A.，Komiya，K.，Honda，A.，Uchida，T.，…Watada，H.(2014).Human IAPP-induced pancreaticβ-cell toxicity and its regulation by autophagy.The Journal of Clinical Investigation，124(8)，3634-3644.

Tiwari，P.，Ahmad，K.，& Hassan baig，M.(2017).Gymnemasylvestre for diabetes：From traditional herb to future's therapeutic.Current Pharmaceutical Design，23(11)，1667-1676.

Tsapras，P.，& Nezis，I.P.(2017).Caspase involvement in autophagy.Cell Death and Differentiation，24(8)，1369-1379.

Tu，Y.J.，Fan，X.，Yang，X.，Zhang，C.，& Liang，H.P.(2013).Evodiamine activates autophagy as a cytoprotective response in murine Lewis lung carcinoma cells.Oncology Reports，29(2)，481-490.

Vellai，R.D.，Chandiran，S.，& Pillai，S.S.(2017).GTF-231，a mixture of gymnemic acid，trigonelline and ferulic acid significantly ameliorates oxidative stress in experimental type 2 diabetes in rats.Canadian Journal of Diabetes，42，237-244.

Wang，J.，Wu，J.，Wu，H.，Liu，X.，Chen，Y.，Wu，J.，…Zou，D.(2015).Liraglutide protects pancreatic beta-cells against free fatty acids in vitro and affects glucolipid metabolism in apolipoprotein E—/—mice by activating autophagy.Molecular Medicine Reports，12(3)，4210-4218.

Wang，Y.，Dawid，C.，Kottra，G.，Daniel，H.，& Hofmann，T.(2014).Gymnemic acids inhibit sodium-dependent glucose transporter Journal of Agricultural and Food Chemistry，62(25)，5925-5931.

Wu，J.，Wu，J.J.，Yang，L.J.，Wei，L.X.，& Zou，D.J.(2013).Rosiglitazone protects against palmitate-induced pancreatic beta-cell death by activation of autophagy via 5＇-AMP-activated protein kinase modulation.Endocrine，44(1)，87-98.

Yoshii，S.R.，& Mizushima，N.(2017).Monitoring and measuring autophagy.International Journal of Molecular Sciences，18(9)，1865.

Yu，L.，Alva，A.，Su，H.，Dutt，P.，Freundt，E.，Welsh，S.，…Lenardo，M.J.(2004).Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8.Science，304(5676)，1500-1502.

Zhang，N.，Cao，M.M.，Liu，H.，Xie，G.Y.，&Li，Y.B.(2015).Autophagy regulates insulin resistance following endoplasmic reticulum stress in diabetes.Journal of Physiology and Biochemistry，71(2)，319-327.