五、治疗
(一)一般治疗
目前尚无理想治疗方法,主要以对症治疗为主,同时应观察和处理中枢神经系统、心脏和肾脏的改变。
(二)口腔颌面部异常相关的治疗建议
对于口腔颌面部出现的皮肤痣或皮脂腺,可以使用液氮冷冻或二氧化碳激光(carbon dioxide laser,CO2 laser)分次进行治疗,可使痣色变浅。
参考文献
[1]唐莉,刘凯,乔树芳,等.表皮痣综合征1例[J].临床皮肤科杂志,2003,32(10):602-603.
[2]林霖霖,蔡剑峰.表皮痣综合征并发多发性基底细胞癌一例[J].中华皮肤科杂志,2002,35(4):315-316.
[3]Happle R.The group of epidermal nevus syndromes[J].Journal of the American Academy of Dermatology,2010,63(1):1-22.(https://www.daowen.com)
[4]Vidaurri-de la Cruz H,Tamayo-Sanchez L,Duran-MckinsterC,et al.Epidermal nevus syndromes:Clinical findings in 35 patients[J].Pediatric Dermatology,2004,21(4):432-439.
[5]Sugarman J L.Epidermal nevus syndromes[J].Seminars in Cutaneous Medicine and Surgery,2007,26(4):221-230.
[6]Rogers M.Epidermal nevi and the epidermal nevus syndromes:A review of 233 cases[J].Pediatric Dermatology,1992,9(4):342-344.
[7]Solomon L M,Fretzin D F,Dewald RL.The epidermal nevus syndrome[J].Arch Dermatol,1968,97(3):273-285.
[8]Pavlidis E,Cantalupo G,Boria S,et al.Hemimegalencephalic variant of epidermal nevus syndrome:Case report and literature review[J].European Journal of Paediatric Neurology,2012,16(4):332-342.
[9]Moreira A I,Ferreira G,Santos M,et al.Epidermal nevus syndrome associated with hypophosphatemic rickets[J].Dermatology Online Journal,2010,16(9):54-68.
[10]Park J H,Hwang E S,Kim S N,et al.Er:YAG laser treatment of verrucous epidermal nevi[J]Dermatologic Surgery,2004,30(3):378-381.
(郑晓姣 杨旭东)