七、参考文献

［1］Teicher BA，Sotomayor EA，Huang ZD.Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and meta- static disease［J］.Cancer Res，1992，52（23）：6702-6704.

［2］Sandstrom M，Johansson M，Bergstrom P，et al.Effects of the VEGFR inhibitor ZD6474in combination with radiotherapy and temozolomide in an orthotopic glioma model［J］.J Neurooncol，2008，88（1）：1-9.

［3］Koontz BF，Miles EF，Rubio MA，et al.Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck：Two case studies［J］.Head Neck，2008，30（2）：262-266.

［4］Williams KJ，Telfer BA，Shannon AM，et al.Combining radiotherapy with AZD2171，a potent Inhibitorof vascular endothelialgrowth factor signaling：pathophysiologic effects and therapeutic benefit［J］.Mol Cancer Ther，2007，6（2）：599-606.

［5］Williams KJ，Telfer BA，Shannon AM，et al.Inhibition of vascular endothelial growth factor signalling using cediranib（RECENTIN； AZD2171）enhances radiation response and causes substantial physiological changes in lung tumour xenografts［J］.Br JRadiol，2008，81：21-27.(https://www.daowen.com)

［6］Cao C，Albert JM，Geng L，et al.Vascular endothelial growth factor tyrosine kinase inhibitor AZD2171 and fractionated radiotherapy in mouse models of lung cancer［J］.Cancer Res，2006，66：11409-11415.

［7］冯久桓，秦叔逵，王琳，等.甲磺酸阿帕替尼的研究现状与进展［J］.临床肿瘤学杂志，2017，22（4）：345-356.

［8］Peng QX，Han YW，Zhang YL，et al.Apatinib inhibits VEGFR-2 and angiogenesis in an in vivo murine model ofnasopharyngeal carcinoma［J］.Oncotarget，2017，8（32）：52813-52822.

（杨 峥）