六、预后
儿童和青少年甲亢易复发,长期服用抗甲状腺药物治疗,缓解率近半数。复发者可考虑用放射性碘或手术治疗以达到根治目的。
参考文献
[1] Abraham-Nordling M, Bystrom K, Torring O, et al.Incidence of hyperthyroidism in Sweden[J].Eur J Endocrinol, 2011, 165(6): 899-905.
[2] Franklyn J A, Boelaert K.Thyrotoxicosis[J].Lancet, 2012,379(9821):1155-1166.
[3] Williamson S, Greene S A.Incidence of thyrotoxicosis in childhood: a national population based study in the UK and Ireland[J].Clin Endocrinol (Oxf) , 2010, 72(3): 358-363.
[4] Krassas G E.Treatment of juvenile Graves'disease and its ophthalmic complication: the“European way” [J].European Journal of Endocrinology, 2004, 150(1): 407-414.
[5] Kaguelidou F, Alberti C, Castanet M, et al.Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatment[J].J Clin Endocrinol Metab, 2008, 93(10): 3817-3826.
[6] Rivkees S A, Dinauer C.An optimal treatment for pediatric Graves’ disease is radioiodine[J].J Clin Endocrinol Metab, 2007, 92(3): 797-800.
[7] Lee J A, Grumbach M M, Clark O H.The optimal treatment for pediatric Graves’ disease is surgery[J].J Clin Endocrinol Metab, 2007, 92(3):801-803.(https://www.daowen.com)
[8] Rivkees S A.Pediatric Graves’ disease: controversies in management[J].Horm Res Paediatr, 2010, 74(5): 305-311.
[9] Kaguelidou F, Carel J C, Leger J.Graves’ disease in childhood: advances in management with antithyroid drug therapy[J].Horm Res, 2009, 71(6):310-317.
[10] Leger J, Kaguelidou F, Alberti C, et al.Graves'disease in children[J].Best Pract Res Cin Endocrinol Metab, 2014,(28) 233-243.
[11] Rivkees S A, Mattison D R.Ending propylthiouracilinduced liver failure in children[J].N Engl J Med, 2009,360(15): 1574-1575.
[12] Leger J, Carel J C.Hyperthyroidism in Childhood:Causes, When and How to Treat[J].J Clin Res Pediatr En docrinol, 2013, 5(Suppl 1): 50-56.
[13] Leger J, Gelwane G, Kaguelidou F, et al.Positive impact of long-term antithyroid drug treatment on the outcome of children with Graves’ disease: national long-term cohort study[J].J Clin Endocrinol Metab, 2012, 97(1):110-119.
[14] 毛晓健, 马晓丹, 刘丽, 等.甲巯咪唑治疗379 例甲状腺功能亢进儿童的单中心临床研究[J].中华内分泌代谢杂志, 2016, 32(1): 6-10.
[15] Sosa J A, Tuggle C T, Wang T S, et al.Clinical and economic outcomes of thyroid and parathyroid surgery in children[J].J Clin Endocrinol Metab, 2008,93(8):3058-3065.