参考文献

参考文献

[1]Sato T,Vries R G,Snippert H J,et al.Single lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.Nature,2009,459(7244):262-265.

[2]Lancaster M A,Renner M,Martin C A,et al.Cerebral organoids model human brain development and microcephaly.Nature,2013,501(7467):373-379.

[3]Homan K A,Gupta N,Kroll K T,et al.Flow-enhanced vascularization and maturation of kidney organoids in vitro.Nat Methods,2019,16(3):255-262.

[4]Asai A,Aihara E,Watson C,et al.Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.Development,2017,144(6):1056-1064.

[5]Camp J G,Sekine K,Gerber T,et al.Multilineage communication regulates human liver bud development from pluripotency.Nature,2017,546(7659):533-538.

[6]Goulart E,De Caires L C,Telles-Silva K A,et al.Adult and ips-derived non-parenchymal cells regulate liver organoid development through differential modulation of wnt and tgf-beta.Stem Cell Res Ther,2019,10(1).

[7]Leeman K T,Pessina P,Lee J H,et al.Mesenchymal stem cells increase alveolar differentiation in lung progenitor organoid cultures.Sci Rep,2019,9(1):6479.

[8]Wynn T A,Chawla A,Pollard J W.Macrophage biology in development,homeostasis and disease.Nature,2013,496(7446):445-455.

[9]Mekala S R,Worsdorfer P,Bauer J,et al.Generation of cardiomyocytes from vascular adventitia-resident stem cells.Circ Res,2018,123(6):686-699.

[10]Stremmel C,Schuchert R,Wagner F,et al.Yolk sac macrophage progenitors traffic to the embryo during defined stages of development.Nat Commun,2018,9(1):75.

[11]Song L,Yuan X,Jones Z,et al.Functionalization of brain region-specific spheroids with isogenic microglia-like cells.Sci Rep,2019,9(1):11055.

[12]Muffat J,Li Y,Omer A,et al.Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to zika and dengue infections.Proc Natl Acad Sci U S A,2018,115(27):7117-7122.

[13]Mansour A A,Goncalves J T,Bloyd C W,et al.An in vivo model of functional and vascularized human brain organoids.Nat Biotechnol,2018,36(5):432-441.

[14]Xu H,Jiao D,Liu A,et al.Tumor organoids:Applications in cancer modeling and potentials in precision medicine.J Hematol Oncol,2022,15(1):58.

[15]Holokai L,Chakrabarti J,Lundy J,et al.Murine-and human-derived autologous organoid/immune cell co-cultures as pre-clinical models of pancreatic ductal adenocarcinoma.Cancers(Basel),2020,12(12):

[16]Yin X,Mead B E,Safaee H,et al.Engineering stem cell organoids.Cell Stem Cell,2016,18(1):25-38.

[17]Takebe T,Zhang B,Radisic M.Synergistic engineering:Organoids meet organs-on-a-chip.Cell Stem Cell,2017,21(3):297-300.

[18]Sunghee Estelle Park A G,Dongeun Huh.Organoids-on-a-chip.Science,2019.

[19]Zhu Y,Wang L,Yu H,et al.In situ generation of human brain organoids on a micropillar array.Lab Chip,2017,17(17):2941-2950.

[20]Liu H,Wang Y,Cui K,et al.Advances in hydrogels in organoids and organs-on-a-chip.Adv Mater,2019,e1902042.

[21]Moroni L,Burdick J A,Highley C,et al.Biofabrication strategies for 3d in vitro models and regenerative medicine.Nat Rev Mater,2018,3(5):21-37.

[22]Bajaj P,Schweller R M,Khademhosseini A,et al.3d biofabrication strategies for tissue engineering and regenerative medicine.Annu Rev Biomed Eng,2014,16(247-276).

[23]Murphy S V,Atala A.3d bioprinting of tissues and organs.Nat Biotechnol,2014,32(8):773-785.

[24]Shin H S,Hong H J,Koh W G,et al.Organotypic 3d culture in nanoscaffold microwells supports salivary gland stem-cell-based organization.Acs Biomater Sci Eng,2018,4(12):4311-4320.

[25]Kakni P,Hueber R,Knoops K,et al.Intestinal organoid culture in polymer film-based microwell arrays.Adv Biosyst,2020,4(10):e2000126.

[26]Decembrini S,Hoehnel S,Brandenberg N,et al.Hydrogel-based milliwell arrays for standardized and scalable retinal organoid cultures.Sci Rep,2020,10(1):10275.

[27]Schepers A,Li C,Chhabra A,et al.Engineering a perfusable 3d human liver platform from ips cells.Lab on a Chip,2016,16(14):2644-2653.

[28]Ootani A,Li X,Sangiorgi E,et al.Sustained in vitro intestinal epithelial culture within a wntdependent stem cell niche.Nature Medicine,2009,15(6):701-706.

[29]Neal J T,Li X,Zhu J,et al.Organoid modeling of the tumor immune microenvironment.Cell,2018,175(7):

[30]Yuki K,Cheng N,Nakano M,et al.Organoid models of tumor immunology.Trends Immunol,2020,41(8):652-664.

[31]Neal J T,Li X,Zhu J,et al.Organoid modeling of the tumor immune microenvironment.Cell,2018,175(7):1972-1988.e1916.

[32]Cattaneo C M,Dijkstra K K,Fanchi L F,et al.Tumor organoid-t-cell coculture systems.Nat Protoc,2020,15(1):15-39.

[33]Dubyak G R.Ion homeostasis,channels,and transporters:An update on cellular mechanisms.AJP Advances in Physiology Education,2005,28(1-4):143-154.

[34]Huch M,Koo B K.Modeling mouse and human development using organoid cultures.Development,2015,142(18):3113-3125.

[35]Manfrin A,Tabata Y,Paquet E R,et al.Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells.Nat Methods,2019,16(7):640-648.

[36]Uzel S G,Amadi O C,Pearl T M,et al.Simultaneous or sequential orthogonal gradient formation in a 3d cell culture microfluidic platform.Small,2016,12(5):612-622.

[37]Rifes P,Isaksson M,Rathore G S,et al.Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic wnt gradient.Nat Biotechnol,2020.

[38]Broguiere N,Isenmann L,Hirt C,et al.Growth of epithelial organoids in a defined hydrogel.Adv Mater,2018,30(43):e1801621.

[39]Ranga A,Girgin M,Meinhardt A,et al.Neural tube morphogenesis in synthetic 3d microenvironments.Proc Natl Acad Sci U S A,2016,113(44):E6831-E6839.

[40]Glorevski N,Sachs N,Manfrin A,et al.Designer matrices for intestinal stem cell and organoid culture.Nature,2016,539(7630):560.

[41]Shkumatov A,Baek K,Kong H.Matrix rigidity-modulated cardiovascular organoid formation from embryoid bodies.PLoS One,2014,9(4):e94764.

[42]Sorrentino G,Rezakhani S,Yildiz E,et al.Mechano-modulatory synthetic niches for liver organoid derivation.Nat Commun,2020,11(1):3416.

[43]Gjorevski N,Sachs N,Manfrin A,et al.Designer matrices for intestinal stem cell and organoid culture.Nature,2016,539(7630):560-564.

[44]Lee K K,Mccauley H A,Broda T R,et al.Human stomach-on-a-chip with luminal flow and peristaltic-like motility.Lab Chip,2018,18(20):3079-3085.

[45]Wang Y,Kim R,Gunasekara D B,et al.Formation of human colonic crypt array by application of chemical gradients across a shaped epithelial monolayer.Cell Mol Gastroenterol Hepatol,2018,5(2):113-130.

[46]Creff J,Courson R,Mangeat T,et al.Fabrication of 3d scaffolds reproducing intestinal epithelium topography by high-resolution 3d stereolithography.Biomaterials,2019,221(119404).

[47]Eiraku M,Takata N,Ishibashi H,et al.Self-organizing optic-cup morphogenesis in threedimensional culture.Nature,2011,472(7341):51-56.

[48]Pham M T,Pollock K M,Rose M D,et al.Generation of human vascularized brain organoids.Neuroreport,2018,29(7):588-593.

[49]Takebe T,Sekine K,Kimura M,et al.Massive and reproducible production of liver buds entirely from human pluripotent stem cells.Cell Rep,2017,21(10):2661-2670.

[50]Holloway E M,Wu J H,Czerwinski M,et al.Differentiation of human intestinal organoids with endogenous vascular endothelial cells.Developmental Cell,2020,54(4):516-528.e517.

[51]Wimmer R A,Leopoldi A,Aichinger M,et al.Human blood vessel organoids as a model of diabetic vasculopathy.Nature,2019,565(7740):505.(https://www.daowen.com)

[52]Sun X Y,Ju X C,Li Y,et al.Generation of vascularized brain organoids to study neurovascular interactions.Elife,2022,11.

[53]Zhou J,Li Y S,Chien S.Shear stress-initiated signaling and its regulation of endothelial function.Arterioscler Thromb Vasc Biol,2014,34(10):2191-2198.

[54]Chistiakov D A,Orekhov A N,Bobryshev Y V.Effects of shear stress on endothelial cells:Go with the flow.Acta Physiol(Oxf),2017,219(2):382-408.

[55]Baeyens N,Bandyopadhyay C,Coon B G,et al.Endothelial fluid shear stress sensing in vascular health and disease.J Clin Invest,2016,126(3):821-828.

[56]Cui K,Chen T,Zhu Y,et al.Engineering placenta-like organoids containing endogenous vascular cells from human-induced pluripotent stem cells.Bioengineering&Translational Medicine,n/a(n/a):e10390.

[57]Liu H,Wang Y,Wang H,et al.A droplet microfluidic system to fabricate hybrid capsules enabling stem cell organoid engineering.Adv Sci(Weinh),2020,7(11):1903739.

[58]Wang Y,Liu H,Zhang M,et al.One-step synthesis of composite hydrogel capsules to support liver organoid generation from hipscs.Biomater Sci,2020,8(19):5476-5488.

[59]Barata D,Van Blitterswijk C,Habibovic P.High-throughput screening approaches and combinatorial development of biomaterials using microfluidics.Acta Biomater,2016,34(1-20).

[60]Kim J A,Hong S,Rhee W J.Microfluidic three-dimensional cell culture of stem cells for highthroughput analysis.World Journal of Stem Cells,2019,11(10):803-816.

[61]Zhang W J,Zhang Y S,Bakht S M,et al.Elastomeric free-form blood vessels for interconnecting organs on chip systems.Lab on a Chip,2016,16(9):1579-1586.

[62]Esch M B,Smith A S T,Prot J M,et al.How multi-organ microdevices can help foster drug development.Adv Drug Deliver Rev,2014,69(158-169).

[63]Oleaga C,Bernabini C,Smith A S T,et al.Multi-organ toxicity demonstration in a functional human in vitro system composed of four organs.Sci Rep-Uk,2016,6.

[64]Esch M B,Smith A S,Prot J M,et al.How multi-organ microdevices can help foster drug development.Adv Drug Deliv Rev,2014,69-70(158-169).

[65]Lee S H,Ha S K,Choi I,et al.Microtechnology-based organ systems and whole-body models for drug screening.Biotechnol J,2016,11(6):746-756.

[66]Lee S H,Sung J H.Microtechnology-based multi-organ models.Bioengineering(Basel),2017,4(2).

[67]Oleaga C,Bernabini C,Smith A S,et al.Multi-organ toxicity demonstration in a functional human in vitro system composed of four organs.Sci Rep,2016,6(20030).

[68]Lee D W,Lee S H,Choi N,et al.Construction of pancreas-muscle-liver microphysiological system(mps)for reproducing glucose metabolism.Biotechnol Bioeng,2019,116(12):3433-3445.

[69]Bauer S,Wennberg Huldt C,Kanebratt K P,et al.Functional coupling of human pancreatic islets and liver spheroids on-a-chip:Towards a novel human ex vivo type 2 diabetes model.Sci Rep,2017,7(1):14620.

[70]Tao T,Deng P,Wang Y,et al.Microengineered multi-organoid system from hipscs to recapitulate human liver-islet axis in normal and type 2 diabetes.Adv Sci(Weinh),2021,e2103495.

[71]Danjo T,Eiraku M,Muguruma K,et al.Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals.J Neurosci,2011,31(5):1919-1933.

[72]Kadoshima T,Sakaguchi H,Nakano T,et al.Self-organization of axial polarity,inside-out layer pattern,and species-specific progenitor dynamics in human es cell-derived neocortex.Proceedings of the National Academy of Sciences of the United States of America,2013,110(50):20284-20289.

[73]Suga H,Kadoshima T,Minaguchi M,et al.Self-formation of functional adenohypophysis in three-dimensional culture.Nature,2011,480(7375):57-U215.

[74]Qian X,Nguyen H N,Song M M,et al.Brain-region-specific organoids using mini-bioreactors for modeling zikv exposure.Cell,2016,165(5):1238-1254.

[75]Chen X,Sun G,Tian E,et al.Modeling sporadic alzheimer's disease in human brain organoids under serum exposure.Adv Sci(Weinh),2021,8(18):e2101462.

[76]Mariani J,Coppola G,Zhang P,et al.Foxg1-dependent dysregulation of gaba/glutamate neuron differentiation in autism spectrum disorders.Cell,2015,162(2):375-390.

[77]Qian X,Nguyen H N,Jacob F,et al.Using brain organoids to understand zika virus-induced microcephaly.Development,2017,144(6):952-957.

[78]Wang Y,Wang L,Zhu Y,et al.Human brain organoid-on-a-chip to model prenatal nicotine exposure.Lab Chip,2018,18(6):851-860.

[79]Karzbrun E,Kshirsagar A,Cohen S R,et al.Human brain organoids on a chip reveal the physics of folding.Nat Phys,2018,14(5):515-522.

[80]Morita R,Suzuki M,Kasahara H,et al.Ets transcription factor etv2 directly converts human fibroblasts into functional endothelial cells.Proc Natl Acad Sci U S A,2015,112(1):160-165.

[81]Cakir B,Xiang Y F,Tanaka Y,et al.Engineering of human brain organoids with a functional vascular-like system.Nat Methods,2019,16(11):1169.

[82]Daviaud N,Friedel R H,Zou H Y.Vascularization and engraftment of transplanted human cerebral organoids in mouse cortex.Eneuro,2018,5(6).

[83]Spence J R,Mayhew C N,Rankin S A,et al.Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.Nature,2011,470(7332):105-109.

[84]Wang X,Yamamoto Y,Wilson L H,et al.Cloning and variation of ground state intestinal stem cells.Nature,2015,522(7555):173-178.

[85]Workman M J,Gleeson J P,Troisi E J,et al.Enhanced utilization of induced pluripotent stem cell-derived human intestinal organoids using microengineered chips.Cell Mol Gastroenterol Hepatol,2018,5(4):669-677.

[86]Nikolaev M,Mitrofanova O,Broguiere N,et al.Homeostatic mini-intestines through scaffoldguided organoid morphogenesis.Nature,2020,585(7826):574.

[87]Schwank G,Koo B K,Sasselli V,et al.Functional repair of cftr by crispr/cas9 in intestinal stem cell organoids of cystic fibrosis patients.Cell Stem Cell,2013,13(6):653-658.

[88]Yoo J H,Donowitz M.Intestinal enteroids/organoids:A novel platform for drug discovery in inflammatory bowel diseases.World J Gastroenterol,2019,25(30):4125-4147.

[89]Little M H,Combes A N.Kidney organoids:Accurate models or fortunate accidents.Genes&Development,2019,33(19-20):1319-1345.

[90]Ryuji,Morizane,Joseph,et al.Kidney organoids:A translational journey.Trends in Molecular Medicine,2017.

[91]Wu H,Uchimura K,Donnelly E L,et al.Comparative analysis and refinement of human pscderived kidney organoid differentiation with single-cell transcriptomics.Cell Stem Cell,2018,23(6).

[92]Shankar A S,Du Z Y,Mora H T,et al.Human kidney organoids produce functional renin.Kidney Int,2021,99(1):134-147.

[93]Lee H N,Choi Y Y,Kim J W,et al.Effect of biochemical and biomechanical factors on vascularization of kidney organoid-on-a-chip.Nano Converg,2021,8(1):35.

[94]Bas-Cristóbal Menéndez A,Du Z,Van Den Bosch T P P,et al.Creating a kidney organoidvasculature interaction model using a novel organ-on-chip system.Sci Rep,2022,12(1):20699.

[95]Trapecar M,Wogram E,Svoboda D,et al.Human physiomimetic model integrating microphysiological systems of the gut,liver,and brain for studies of neurodegenerative diseases.Sci Adv,2021,7(5).

[96]Skardal A,Aleman J,Forsythe S,et al.Drug compound screening in single and integrated multiorganoid body-on-a-chip systems.Biofabrication,2020,12(2):025017.

[97]Skardal A,Murphy S V,Devarasetty M,et al.Multi-tissue interactions in an integrated threetissue organ-on-a-chip platform.Sci Rep,2017,7(1):8837.

[98]Yin F,Zhang X,Wang L,et al.Hipsc-derived multi-organoids-on-chip system for safety assessment of antidepressant drugs.Lab Chip,2021,21(3):571-581.

[99]Wang Y Q,Wang H,Deng P W,et al.In situ differentiation and generation of functional liver organoids from human ipscs in a 3d perfusable chip system.Lab on a Chip,2018,18(23):3606-3616.

[100]Wang Y,Wang H,Deng P,et al.Modeling human nonalcoholic fatty liver disease(nafld)with an organoids-on-a-chip system.Acs Biomater Sci Eng,2020,6(10):5734-5743.

[101]Qian X Y,Nguyen H N,Song M M,et al.Brain-region-specific organoids using minibioreactors for modeling zikv exposure.Cell,2016,165(5):1238-1254.

[102]Garcez P P,Loiola E C,Da Costa R M,et al.Zika virus impairs growth in human neurospheres and brain organoids.Science,2016,352(6287):816-818.