五、治疗

五、治疗

(一)一般治疗

一般不需治疗。多数作者认为可按急性或慢性苔藓样糠疹来治疗。

有报道,四环素,高效皮质类固醇激素,光化学疗法(photochemotherapy,PUVA)或氨甲蝶呤(methotrexate,MTX)可用于全身治疗而有一定疗效。有人采用免疫增强剂如左旋咪唑(levamisole)治疗,是否可增强免疫功能以达到疗效,值得进一步探讨。有文献报道,可局部应用卡莫司汀(卡氮芥)(carmustine)治疗本病。

(二)口腔颌面部异常相关的治疗建议

对症处理,预防继发感染。

参考文献(https://www.daowen.com)

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[2]Allabert C,Estève E,Joly P,et al.Mucosal involvement in lymphomatoid papulosis:four cases[J].Ann Dermatol Venereol,2008,135(4):273-278.

[3]Bruijn M S,Horváth B,van Voorst Vader P C,et al.Recommendations for treatment of lymphomatoid papulosis with methotrexate:A report from the Dutch Cutaneous Lymphoma Group[J].British Journal of Dermatology,2015,173(5):1319-1322.

[4]Mori M,Manuelli C,Pimpinelli N,et al.CD30-CD30 ligand interaction in primary cutaneous CD30(+)T-cell lymphomas:A clue to the pathophysiology of clinical regression[J].Blood,1999,94(9):3077-3083.

[5]Wieser I,Oh C W,Talpur R,et al.Lymphomatoid papulosis:Treatment response and associated lymphomas in a study of 180 patients[J].Journal of the American Academy of Dermatology,2016,74(1):59-67.

(郑晓姣 王志勇)