4.2 术后标本系膜完整性评估
Leeds 大学的West 教授研究了结肠系膜的病理特征与病人预后的关系,按照结肠系膜完整程度将结肠癌标本分为固有肌层暴露组、系膜不完整组和系膜完整组。这种分级标准简便、易于掌握,但指标过于单一[15]。Benz 教授在此基础上增加了针对系膜切除范围的评估[17],分为四个等级:0 型(真正的CME 标本),回结肠血管和结肠中血管根部通过外科干表面的组织(覆盖SMV 的淋巴组织)连接,结肠系膜窗具有完整的内侧结肠系膜框架;Ⅰ型,回结肠血管和结肠中血管完整可见,但中间无组织相连,结肠系膜窗内侧框架不完整;Ⅱ型,回结肠血管可见,长度大于预期长度50%以上,结肠中血管不可见,结肠系膜窗内侧及周边框架缺失;Ⅲ型,回结肠血管长度小于预期长度的50%,结肠系膜窗缺失。该评价标准兼顾了系膜完整性及系膜切除范围的评估,但仍忽略了对手术区域系膜床的评估以及血管结扎部位的评估。
目前我们结合膜解剖的理念,评估标准包括四个方面:① 系膜完整性的评价;② 系膜床完整性的评价;③ 是否在SMA 左侧离断系膜;④ 是否在血管起始部夹闭切断。
要建立一个全面的评估体系须包括:① 完整的影像数据库,包括手术的完整录像以及手术清扫结束后手术野及肠系膜上血管的照片,同时还应保留离体标本展平后正反面照片;② 肿瘤相关数据的测量,包括肿瘤的大小、所在部位、距近切缘和远切缘距离,系膜的长度、面积;③ 完整的病理及免疫组化检查结果,尤其要注意淋巴结的取材和分站要规范,淋巴结的转移情况以及环周切缘是否阴性;④ 如条件许可,留取清扫前后的冲洗液,通过RT-PCR 检测对比,了解有无肉眼无法察觉的癌泄露情况。通过这个评估体系,我们期待能提供更客观的临床数据,规范腹腔镜右半结肠根治术的手术方式和手术细节。
(童宜欣、龚建平)
参考文献
[1]BRAY F,et al.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].CA Cancer J Clin,2018,68(6): 394-424.
[2]VENOOK A P.Right-sided vs.left-sided colorectal cancer[J].Clin Adv Hematol Oncol,2017,15(1): 22-24.
[3]HEALD R J,RYALL R D.Recurrence and survival after total mesorectal excision for rectal cancer [J].Lancet,1986,1(8496): 1479-1482.
[4]HOHENBERGER W,et al.Standardized surgery for colonic cancer: complete mesocolic excision and central ligation-technical notes and outcome[J].Colorectal Dis,2009,11(4): 354-364; discussion 364-365.
[5]COFFEY J C,O'LEARY D P.The mesentery: structure,function,and role in disease [J].Lancet Gastroenterol Hepatol,2016,1(3): 238-247.
[6]篠原尚,等.图解外科手术:从膜的解剖解读术式要点[M].2013.(https://www.daowen.com)
[7]三毛牧夫,张宏,刘金钢.腹腔镜下大肠癌手术 [M].2015.
[8]龚建平.胃癌第五转移与第三根治原则 [J].中华胃肠外科杂志,2013,16(2): 109-110.
[9]龚建平.外科膜解剖——新的外科学基础[J].中华实验外科杂志,2015,32(2): 225-226.
[10]龚建平.膜解剖的兴起与混淆[J].中华胃肠外科杂志,2019,22(5): 401-405.
[11]XIE D,et al.Mesogastrium: a fifth route of metastasis in gastric cancer? [J].Med Hypotheses,2013,80(4): p.498-500.
[12]XIE D,et al.An Optimal Approach for Laparoscopic D3 Lymphadenectomy Plus Complete Mesocolic Excision (D3+CME) for Right-Sided Colon Cancer [J].Ann Surg Oncol,2016.
[13]MURONO K,et al.Evaluation of the vascular anatomy of the right-sided colon using three-dimensional computed tomography angiography: a single-center study of 536 patients and a review of the literature[J].Int J Colorectal Dis,2016,31(9): 1633-1638.
[14]WATANABE T,et al.Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer[J].Int J Clin Oncol,2017.
[15]WEST N P,et al.Understanding optimal colonic cancer surgery: comparison of Japanese D3 resection and European complete mesocolic excision with central vascular ligation[J].J Clin Oncol,2012,30(15): 1763-1769.
[16]TREVES F.Lectures on the Anatomy of the Intestinal Canal and Peritoneum in Man [J].Br Med J,1885,1(1264): 580-583.
[17]BENZ S,et al.Proposal of a new classification system for complete mesocolic excison in right-sided colon cancer [J].Tech Coloproctol,2019,23(3): 251-257.