3.1 Ginsenosides Reduced the Percentages of Apopto...
After 48h stimulation，high glucose or cytokines increasedβ-cells apoptosis by 2.50 and 4.74 fold，respectively.However，after co-culturing with Rg1 or Rb1，the percentages of apoptotic cells were largely reduced，and Rb1 is more effective than Rg1.When the two ginsenosides were put together，anti-apoptotic effect was more evident(Figure 1).
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Figure 1 Effects of Ginsenosides on High Glucose/Cytokines-Induced Apoptosis Rate in Rin-m5F Cells
A and B，Rin-m5F cells were induced by high glucose and treated with or without ginsenosides；C and D，cells were induced by cytokines and treated with or without ginsenosides.A and C showed the percentages of apoptotic cells，and Band D were the FACShistogram.The results are reported as mean±S.E.M.of 3 independent experiments.**p＜0.01 vs.control group；# p＜0.05，## p＜0.01 vs.high glucose/cytokine group.1：control group；2：high glucose group；3：high glucose+Rg1 group；4：high glucose+Rg1 group；5：high glucose+Rg1+Rb1 group；6：cytokine group；7：cytokine+Rg1 group；8：cytokine+Rg1 group；9：cytokine+Rg1+Rb1 group.