3.2 Ginsenosides Protected High Glucose/Cytokines-Impaired Insulin Secretion
After exposure to high glucose or cytokines,the insulin concentrations of supernatant significantly decreased to 60.48% or 63.33%compared to control group.Ginsenoside Rg1 or Rb1 protected high glucose/cytokines-impaired insulin secretion.However,two ginsenosides together did not show additional effect on this protective function(Figure 2).
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Figure 2 Effects of Ginsenosides on Insulin Secretion in Rin-m5F Cells Induced by High Glucose/Cytokine
A,cells were induced by high glucose and treated with or without ginsenosides;B,cells were induced by cytokines and treated with or without ginsenosides.Data are shown as mean±S.E.M.of 3 independent experiments.**p<0.01 vs.control group;#p<0.01 vs.high glucose/cytokine group.