七、结论

七、结论

亚临床甲减是很常见的疾病,尤其在老年女性中。对于血清TSH水平超过10mIU/L的患者是需要治疗的,其治疗的目的是要预防进一步的发展为临床甲减。对于年龄校正后血清TSH水平在正常值的97.5%以上,或是血清TPOAb高水平的患者,治疗可能会阻止和延缓临床甲减发生,改善脂代谢异常和心血管功能指标,但尚不清楚是否可以降低心血管疾病的发生风险。对于血清TSH水平小于10mIU/L的患者的治疗是否可以改善其认知和临床症状,尚没有足够证据加以证明。对于老年人,治疗时可能产生包括心肌缺血和心律失常的风险[47],亟须日后设计更完善的实验来加以评估。对于妊娠早期亚临床甲减患者推荐进行甲状腺激素治疗。年轻人在不考虑治疗费用的前提下,也应该进行治疗。

参考文献

[1] Peeters, R.P., Subclinical Hypothyroidism[J].N Engl J Med, 2017,376(26):2556-2565.

[2]中华内分泌学会.成人甲状腺功能减退症诊治指南[J].中华内分泌代谢杂志,2017,33(2):167-180.

[3] Baloch Z 1,Carayon P,Conte-Devolx B,et al.Laboratory medicine practice guidelines.Laboratory support for the diagnosis and monitoring of thyroid disease[J].Thyroid.2003 ,13(1):3-126.

[4] Garber J R,Cobin R H,Gharib H, et al.Clinical Practice Guidelines for Hypothyroidism in Adults:Cosponsored by The American THyroid Association of Clinical Endocrinologists and The American Thyriod Association[J].Thyroid,2012 ,22(12):1200-1235.

[5] LI Chen-yan,GUAN Hai-xia, TENG Xiao-chun, et al,The reference range of serum thyrotropin in iodinesufficient areas: An epidemiological study[J].Chin J Endocrinol Metab, 2011, Vol.27, No.6.

[6] Zhang X,Yao B,Li C,et al.Reference intervals of thyroid function during pregnancy: self-sequential longitudinal study vs cross-sectional study[J].Thyroid, 2016,26(12):1786-1793 .

[7] Weiping Teng, Z.S., Komal Patil-Sisodia,et al,Hypothyroidism in pregnancy[J].Lancet Diabetes Endocrinol, 2013, 1: 228-237.

[8] Surks M I,Hollowell J G.Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism[J].J Clin Endocrinol Metab, 2007 ,92(12):4575-4582.

[9] Hamburger J I,Meier D A,Szpunar W E.Factitious elevation of thyrotopin in euthyroid patients[J].N Engl J Med, 1985,313(4):267-268.

[10] Teng, W.Effect of iodine intake on thyroid diseases in China[J].N Engl J Med,2006,354(26): 2783-2793.

[11] Meyerovitch J,Rotman-Pikielny P,Sherf M,et al.Serum thyrotropin measurements in the commIUnity: fiveyear follow-up in a large network of primary care physicians[J].Arch Intern Med, 2007,167(14):1533-1538.

[12] Moulin de Moraes C M,Mancini M C,de Melo ME,et al.Prevalence of subclinical hypothyroidism in a morbidly obese population and improvement after weight loss induced by Roux-en-Y gastric bypass[J].Obes Surg,2005,15(9):1287-1291.

[13] Tunbridge W M,Evered D C,Hall R,et al.The spectrum of thyroid disease in a commIUnity: the Whickham survey[J].Clin Endocrinol (Oxf), 1977 ,7(6):481-493.

[14] Hollowell J G,Staehling N W,Flanders W D,et al.Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANESⅢ) [J].J Clin Endocrinol Metab, 2002,87(2):489-499.

[15] Bagchi N,Brown T R,Parish RF.Thyroid dysfunction in adults over age 55 years.A study in an urban US commIUnity[J].Arch Intern Med, 1990 ,150(4):785-787.

[16] Sawin C T,Chopra D,Azizi F,et al.The aging thyroid.Increased prevalence of elevated serum thyrotropin levels in the elderly[J].JAMA, 1979,242(3):247-250.

[17] Geul K W 1,van Sluisveld I L,Grobbee D E,et al.The importance of thyroid microsomal antibodies in the development of elevated serum TSH in middle-aged women: associations with serum lipids[J].Clin Endocrinol(Oxf), 1993 ,39(3):275-280.

[18] Kwon, H.Age-specific reference interval of serum TSH levels is high in adolescence in an iodine excess area:Korea national health and nutrition examination survey data[J].Endocrine, 2017,57(3):445-454.

[19] Klein R Z 1,Haddow J E,Faix J D,et al.Prevalence of thyroid deficiency in pregnant women[J].Clin Endocrinol(Oxf), 1991,35(1):41-46.

[20] Vanderpump M P 1,Tunbridge W M,French J M,et al.French JM, et al.The incidence of thyroid disorders in the commIUnity: a twenty-year follow-up of the Whickham Survey[J].Clin Endocrinol (Oxf), 1995,43(1):55-68.

[21] Huber G,Staub J J,Meier C, et al.Prospective study of the spontaneous course of subclinical hypothyroidism:prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies[J].J Clin Endocrinol Metab,2002,87(7):3221-3226.

[22] Rosenthal M J,Hunt W C,Garry P J,et al.Thyroid failure in the elderly.Microsomal antibodies as discriminant for therapy[J].JAMA, 1987,258(2):209-213.

[23] Hak A E, Pols H A, Visser T J, et al.Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study[J].Ann Intern Med,2000,132(4):270-278.(https://www.daowen.com)

[24] Rodondi N,Newman A B,Vittinghoff E,et al.Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death[J].Arch Intern Med,2005 ,165(21):2460-2466.

[25] Walsh J P, Bremner A P, Bulsara M K, et al.Subclinical thyroid dysfunction as a risk factor for cardiovascular disease[J].Arch Intern Med, 2005 ,165(21):2467-2472.

[26] Cappola A R, Fried L P, Arnold A M,et al.Thyroid status,cardiovascular risk, and mortality in older adults[J].JAMA, 2006 ,295(9):1033-1041.

[27] Rodondi N, Bauer D C, Cappola A R, et al.Subclinical thyroid dysfunction, cardiac function, and the risk of heart failure.The Cardiovascular Health study[J].J Am Coll Cardiol, 2008,52(14):1152-1159.

[28] Boekholdt S M, Titan S M, Wiersinga WM, et al.Initial thyroid status and cardiovascular risk factors: the EPICNorfolk prospective population study[J].Clin Endocrinol(Oxf), 2010,72(3):404-410.

[29] Rodondi N, den Elzen W P, Bauer D C,et al.Subclinical hypothyroidism and the risk of coronary heart disease and mortality[J].JAMA, 2010,304(12):1365-1374.

[30] Villar H C,Saconato H,Valente O,et al, Thyroid hormone replacement for subclinical hypothyroidism[J].Cochrane Database Syst Rev, 2007 ,(3):CD003419.

[31] Kong W M,Sheikh M H,Lumb P J, et al.A 6-month randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism[J].Am J Med,2002,112(5):348-354.

[32] Caraccio N,Ferrannini E,Monzani F.Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study[J].J Clin Endocrinol Metab, 2002 ,87(4):1533-1538.

[33] Monzani F1,Di Bello V,Caraccio N, et al.Effect of levothyroxine on cardiac function and structure in subclinical hypothyroidism: a double blind, placebocontrolled study[J].J Clin Endocrinol Metab,2001,86(3):1110-1115.

[34] Canaris G J,Manowitz N R,Mayor G,et al.The Colorado thyroid disease prevalence study[J].Arch Intern Med,2000 ,160(4):526-534.

[35] Danese M D,Ladenson P W,Meinert C L,et al.Clinical review 115: effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature[J].J Clin Endocrinol Metab, 2000 ,85(9):2993-3001.

[36] Tanis B C,Westendorp G J,Smelt H M.Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a reanalysis of intervention studies[J].Clin Endocrinol (Oxf), 1996 ,44(6):643-649.

[37] Tappy L,Randin J P,Schwed P,et al.Prevalence of thyroid disorders in psychogeriatric inpatients.A possible relationship of hypothyroidism with neurotic depression but not with dementia[J].J Am Geriatr Soc, 1987,35(6):526-531.

[38] Joffe R T,Levitt A J.Major depression and subclinical(grade 2) hypothyroidism[J].Psychoneuroendocrinology,1992,17(2-3):215-221.

[39] Tan Z S,Beiser A,Vasan R S,et al.Thyroid function and the risk of Alzheimer disease: the Framingham Study[J].Arch Intern Med, 2008,168(14):1514-1520.

[40] SamIUels M H,Schuff K G,Carlson N E,et al.Health status, mood, and cognition in experimentally induced subclinical hypothyroidism[J].J Clin Endocrinol Metab,2007,92(7):2545-2551.

[41] Correia N,MIUllally S,Cooke G,et al.Evidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism[J].J Clin Endocrinol Metab,2009 ,94(10):3789-3797.

[42] Surks M I,Ortiz E,Daniels G H,et al.Subclinical thyroid disease: scientific review and guidelines for diagnosis and management[J].JAMA, 2004 ,291(2):228-238.

[43] Gharib H,Tuttle R M,Baskin H J,et al.Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists,the American Thyroid Association, and the Endocrine Society[J].J Clin Endocrinol Metab, 2005 ,90(1):581-585; discussion 586-587.

[44] Razvi S,Weaver J U,Vanderpump M P,et al.The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort[J].J Clin Endocrinol Metab,2010,95(4):1734-1740.

[45] Somwaru L L,Arnold A M,Joshi N,et al.High frequency of and factors associated with thyroid hormone overreplacement and under-replacement in men and women aged 65 and over[J].J Clin Endocrinol Metab,2009,94(4):1342-1345.

[46] Gussekloo J,van Exel E,de Craen AJ,et al.Thyroid status,disability and cognitive function, and survival in old age[J].JAMA, 2004 ,292(21):2591-2599.

[47] Chu J W,Crapo L M.The treatment of subclinical hypothyroidism is seldom necessary[J].J Clin Endocrinol Metab, 2001 ,86(10):4591-4599.