6.4 Case Report:Severe Acute Post-infectious Glome...
A 6-year-old boy，with no prior medical history，was admitted to the University Hospital of Lausanne with gross hematuria，abdominal pain，and oliguria.He reported pharyngitis 7 days earlier.On physical exam，there was no edema，and cardiovascular，pulmonary，neurological，and dermatal examinations were all unremarkable.Blood pressure was 120/90 mmHg.Urinalysis displayed numerous red blood cell casts，dysmorphic red blood cells，and proteinuria.A complete blood count showed a normocytic non-hemolytic anemia.The C3 levels were assessed by nephelometry（BNP Prospec，Siemens Behring）with reference ranges supplied by the vendor（normal range 75-175 mg/dl）.Plasma sC5b-9 level was measured with an ELISA kit.No anti-Factor B and H autoantibodies were detected，but C3 Nephritic Factor（C3NeF）was present.Anti-nuclear antibodies and anti-neutrophil cytoplasmic antibodies were undetectable.
Twelve hours after admission，the child developed anuria，and his serum creatinine and urea nitrogen levels further increased to 347 and 26.1 mmol/L，respectively，associated with hyperkalemia（5.6 mmol/L），hyponatremia（128 mmol/L），hyperphosphatemia（2.97 mmol/L），and metabolic acidosis（bicarbonate 19 mmol/L）.Renal biopsy showed exudative diffuse glomerulonephritis with enlarged and hypercellular glomerular tufts.In view of the renal biopsy and the severity of the acute post-infections glomerulonephritis（PIGN），a single dose of intravenous eculizumab（600 mg）was administered with parental consent.The child had already received meningococcal immunization with a tetravalent conjugated vaccine.Daily antibiotic prophylaxis with penicillin V was administered for a total of 6 weeks.The response was immediate，with brisk diuresis starting 12 h after eculizumab administration.Serum creatinine level normalized in 48 h，and proteinuria decreased dramatically and normalized after 2 months.Genetic analyses of the alternative pathway complement proteins were normal.Two years later，the child is doing well with normal blood pressure，normal renal function，normal complement levels，undetectable C3NeF，normal urinalysis，and no proteinuria.
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Task 8 Translate the following sentences into Chinese.
1.On physical exam，there was no edema，and cardiovascular，pulmonary，neurological，and dermatal examinations were all unremarkable.
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2.Urinalysis displayed numerous red blood cells casts，dysmorphic red blood cells，and proteinuria.
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3.Renal biopsy showed exudative diffuse glomerulonephritis with enlarged and hypercellular glomerular tufts.
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4.In view of the renal biopsy and the severity of the acute post-infections glomerulonephritis（PIGN），a single dose of intravenous eculizumab（600 mg）was administered with parental consent.
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5.Daily antibiotic prophylaxis with penicillin V was administered for a total of 6 weeks.
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