参考文献
[1]Ambros V.A hierarchy of regulatorygenes controls a larva-to-adult developmental switch in C.elegans.Cell,1989,57:49-57.
[2]Ambros V,Lee R C,Lavanway A,et al.MicroRNAs and other tiny endogenous RNAs in C.elegans.Curr Biol,2003,13:807-818.
[3]Aravin A A,Naumova N M,Tulin A A,et al.Double-stranded RNA-mediated silencing ofgenomic tandem repeats and transposable elements in D.melanogastergermline.Curr Biol,2001,11:1017-1027.
[4]Beck S,Ole K A.Epigenome—molecular hide and seek.Weinbeim:Wiley-Vch Verlaggmb & Co KGak,2003.
[5]Brockdorff N.Chromosome silencing mechanisms in X chromosome inactivation:unknown unknowns.Development,2011,138:5057-5065.
[6]Chahwan R,Wontakal S N,Roa S.The multidimensional nature of epigenetic information and its role in disease.Discovery Medicine,2011,11:233-243.
[7]Carthew R H,Sontheimer E J.Origins and mechanisms of miRNAs and siRNAs.Cell,2009,136:642-655.
[8]Djebali S,Davis C A,Merkel A,et al.Landscape of transcription in human cells.Nature,2012,489:101-108.
[9]Ehrlich M,Sanchez C,Shao C,et al.ICF,an immunodeficiency syndrome:DNA methyltransferase 3B involvement,chromosome anomalies,andgene dysregulation.Autoimmunity,2008,41:253-271.
[10]Feinberg A P,Oshimura M,Barrett C.Epigenetic mechanism in human disease.Cancer Res,2002,62:6784-6787.
[11]Feinberg A P,Tycko B.The history of cancer epigenetics.Nat Rev Cancer,2004,4:143-153.
[12]Franklin T B,Mansuy I M.Epigenetic inheritance in mammals:evidence for the impact of adverse environmental effects.Neurobiol Dis,2010,39:61-65.
[13]Fire A,Xu S,Montgomery M K,et al.Potent and specificgenetic interference by double-stranded RNA in Caenorhabditis elegans.Nature,1998,391:806-811.
[14]grieshammer U,Shepard K A,Nigh E A,et al.Finding the niche for human somatic cell nuclear transfer.Nature Biotechnology,2011,29:701-705.
[15]griffiths A J F,Wessler S R,Richard C,et al.An introduction togenetic analysis.8th ed.New York:W.H.Freeman and Company,2005.
[16]Hannumg,guinney J,Zhao L,et al.Genome-wide methylation profiles reveal quantitative views of human aging rates.Molecular Cell,2012,49:359-367.
[17]Heijmans B T,Tobi E W,Stein A D,et al.Persistent epigenetic differences associated with prenatal exposure to famine in humans.Proc Natl Acad Sci USA,2008,105:17046-17049.
[18]Huang C ,Sloan E ,Boerkoel C F.Chromatin remodeling and human disease.Curr Opingenet Dev,2003,13:246-252.
[19]Jonkers I,Barakat T S,Achame E M,et al.RNF12 is an X-encoded dosedependent activator of X chromosome inactivation.Cell,2009,139:999-1011.
[20]Kelly T L J,Trasler J M.Reproductive epigenetics.Clingemet,2004,65:247-260.
[21]Laid P W.The power and promise of DNA methylation markers.Nat Rev Cancer,2003,3:253-266.
[22]Law M J,Lower K M,Voon H P,et al.ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner. Cell,2010,43:367-378.
[23]Lee J T.Epigenetic regulation by long noncoding RNAs.Science,2012,338:1435-1439.
[24]Lewin B.Genes Ⅷ.New Jersey:Pearson Education Inc,2004.
[25]Murrell A,Heeson S,Cooper W N,et al.An association between variants in the IGF2gene and beckwith-wiedmann syndrome:interaction betweengenotype and epigenotype.Hum Molgenet,2004,13:247-255.
[26]Nora E P,Heard E.X chromosome inactivation:when dosage counts.Cell,2009,139:865-867.
[27]Nora E P,Lajoie B R,Schulz Eg,et al.Spatial partitioning of the regulatory landscape of the X-inactivation centre.Nature,2012,485:381-385.
[28]Rakyan V K,Preis J,Morgan H D,et al.The marks,mechanisms and memory of epigenetic states in mammals.Biochem J,2001,356:1-10.
[29]Reik W,Dean W,Walter J.Epigenetic reprogramming in mammalian development.Science,2001,293:1089-1093.
[30]Reik W,Walter J.Genomic imprinting:parental influence on thegenome.Nature Reviewsgenetics,2001,2:21-32.
[31]Rodriguez-Revenga L,Madrigal I,Blanch-Rubió J,et al.Screening for the presence of FMR1 premutation alleles in women with fibromyalgia.Gene,2013,512:305-308.
[32]Sigovaa A A,Mullen A C,Molinieb B,et al.Divergent transcription of long noncoding RNA/mRNAgene pairs in embryonic stem cells.Proc Natl Acad Sci USA,2013,110:2876-2881.
[33]Vogel F,Motulsky Ag.人类遗传学—问题与方法.罗会元,主译.北京:人民卫生出版社,1999:361-383.
[34]Vu T H,Hoffman A R.Comparativegenomics sheds light on mechanisms ofgenomic imprinting.Genome Res,2000,10:1660-1663.
[35]Wang K C,Chang H Y.Molecular mechanisms of long noncoding RNAs.Molecular Cell,2011,43:904-914.
[36]Waterland R A,Jirtle R A.Transposable elements:targets for early nutritional effects on epigeneticgene regulation.Mol Cell Biol,2003,23:5293-5300.
[37]Weksberg R,Shuman C,Beckwith J B.Beckwith-wiedemann syndrome.European Journal of Humangenetics,2010,18:8-14.
[38]Whitehousei L,Owen-Hughes T.ATRX:put me on repeat.Cell,2010,143:335-336.
[39]Yin Q F,Yang L,Zhang Y,et al.Long noncoding RNAs with snoRNA ends.Mol Cell,2012,48:219-230.