四、结论
T2DM可显著增强小鼠的骨吸收代谢，其生物学机制与小鼠骨中GPR48表达下调进而激活OPG／RANKL／RANK分子轴及其下游CN／NFAT信号通路中相关细胞因子表达，促进BMM向破骨细胞分化，以及TRAP活性增强有关。
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