参考文献
姜宗来. 低切应力对血管重建的影响［A］. 中国病理生理学会. 国际心脏研究会中国分会第八届学术会议暨中国病理生理学会心血管专业委员会第十一届学术会议论文摘要集［C］.中国病理生理学会: 中国病理生理学会, 2004: 1.
邱菊辉. Id1调控血管新生参与动脉粥样硬化易损斑块形成及其机制［D］. 重庆：重庆大学, 2011.
邱菊辉, 王贵学, 雷道希. 血流动力学与动脉粥样硬化斑块的稳定性及其机制［J］. 中国动脉硬化杂志, 2009, 17（06）: 495-497.
危当恒, 王贵学, 王佐，等. 剪切应力对家兔血管内膜增生及动脉粥样硬化斑块形成的影响［J］.中国动脉硬化杂志, 2007, 15（6）: 410-414.
王贵学. 切应力变化与动脉粥样硬化斑块的形成和破裂［J］. 中国动脉硬化杂志, 2009, 17（8）: 625-628.
Blythe N M, Muraki K, Ludlow M J, et al. Mechanically activated Piezo1 channels of cardiac fi broblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion［J］. Journal of Biological Chemistry, 2019, 294: 17395-17408.
Cancel L M, Tarbell J M. The role of mitosis in LDL transport through cultured endothelial cell monolayers［J］. Am J Physiol Heart Circ Physiol, 2011, 300（3）: H769-H776.
Cancel L M, Tarbell J M. The role of apoptosis in LDL transport through cultured endothelial cell monolayers［J］. Atherosclerosis, 2010, 208（2）: 335-341.
Cecchi E, Giglioli C, Valente S, et al. Role of hemodynamic shear stress in cardiovascular disease［J］. Atherosclerosis, 2011, 214（2）: 249-256.
Chang L, Azzolin L, Biagio D, et al. The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ［J］. Nature, 2018, 563（7730）: 265-269.
Chatzizisis Y S, Coskun A U, Jonas M, et al. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior［J］. J Am Coll Cardiol, 2007, 49（25）: 2379-2393.
Chatzizisis Y S, Giannoglou G D. Shear stress and inflammation: are we getting closer to the prediction of vulnerable plaque［J］. Expert Rev Cardiovasc Ther, 2010, 8（10）: 1351-1353.
Chatzizisis Y S, Jonas M, Coskun A U, et al. Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study［J］. Circulation, 2008, 117（8）: 993-1002.
Chiu J J, Chien S. Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives［J］. Physiol Rev, 2011, 91（1）: 327-387.
Clarke M C, Figg N, Maguire J J. Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis［J］. Nat Med, 2006, 12（9）:1075-1080.
Cunningham K S, Gotlieb A L. The role of shear stress in the pathogenesis of atherosclerosis［J］. Lab Invest, 2005, 85（1）: 9-23.
Silva R F, Chambaz C, Stergiopulos N, et al. Transcriptional and post-transcriptional regulation of preproendothelin-1 by plaque-prone hemodynamics［J］. Atherosclerosis, 2007, 194（2）: 383-390.
Davies J E, Lopresto D, Apta B, et al. Using Yoda-1 to mimic laminar fl ow in vitro: a tool to simplify drug testing［J］. Biochemical Pharmacology, 2019, 168: 473-480.
Davies P F, Civelek M, Fang Y, et al. The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo［J］. Cardiovasc Res, 2013, 99（2）: 315-327.
Douguet D, Patel A, Xu A, et al. Piezo ion channels in cardiovascular Mechanogy［J］. Trends in Pharmacological Sciences, 2019, 40: 956-970.
Fang C, Schmaier A H. Novel anti-thrombotic mechanisms mediated by mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems［J］. Pharmacol Res, 2020, 160: 105096.
Fisslthaler B, Boengler K, Fleming I, et al. Identification of a cis-element regulating transcriptional activity in response to fl uid shear stress in bovine aortic endothelial cells［J］. Endothelium, 2003, 10（4-5）: 267-275.
Fukumoto Y, Hiro T, Fujii T, et al. Localized elevation of shear stress is related to coronary plaque rupture: a 3-dimensional intravascular ultrasound study with in-vivo color mapping of shear stress distribution［J］. J Am Coll Cardiol, 2008, 51（6）: 645-650.
Gijsen F J, Wentzel J J, Thury A, et al. A new imaging technique to study 3-D plaque and shear stress distribution in human coronary artery bifurcations in vivo［J］. J Biomech, 2007, 40（11）: 2349-2357.(https://www.daowen.com)
Herrmann J, Lerman L, Lerman A. Simply say yes to no? Nitric oxide（NO）sensor-based assessment of coronary endothelial function［J］. Eur Heart J, 2010, 31（23）: 2834-2836.
Hsu P L, Chen J S, Wang C Y, et al. Shear-induced CCN1 promotes atheroprone endothelial phenotypes and atherosclerosis［J］. Circulation, 2019, 139（25）: 2877-2891.
Huang J, Pu Y, Zhang H, et al. KLF2 mediates the suppressive effect of laminar flow on vascular calcification by Inhibiting endothelial BMP/SMAD1/5 signaling［J］. Circ Res, 2021, DOI: 10.1161/CIRCRESAHA.120.318690.
Koskinas K C, Chatzizisis Y S, Papafaklis M I, et al. Synergistic effect of local endothelial shear stress and systemic hypercholesterolemia on coronary atherosclerotic plaque progression and composition in pigs［J］. Int J Cardiol, 2013, 169（6）: 394-401.
Liu S, Jiang X, Cui X, et al. Smooth muscle-specifi c hur knockout induces defective autophagy and atherosclerosis. Cell Death Dis, 2021, 12（4）: 385.
Mehta V, Pang K L, Givens C S, et al. Mechanical forces regulate endothelial-to-mesenchymal transition and atherosclerosis via an Alk5-Shc mechanotransduction pathway［J］. Sci Adv, 2021, 7（28）: eabg5060.
Mehta V, Pang K L, Rozbesky D, et al. The guidance receptor plexin D1 is a mechanosensor in endothelial cells［J］. Nature, 2020, 578: 290-295.
Meli V S, Atcha H, Veerasubramanian P K, et al. YAP-mediated mechanotransduction tunes the macrophage infl ammatory response. Sci Adv, 2020, 6（49）: eabb8471.
Parmar K M, Larman H B, Dai G, et al. Integration of fl ow-dependent endothelial phenotypes by Kruppel-like factor 2［J］. J Clin Invest, 2006, 116（1）: 49-58.
Petzold T, Orr A W, Hahn C, et al. Focal adhesion kinase modulates activation of NF-kappaB by fl ow in endothelial cells［J］. Am J Physiol Cell Physiol, 2009, 297（4）: C814-822.
Potje S R, Paula T D, Paulo M, et al. The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases［J］. Front Physiol, 2021, 11:620840.
Qiu J, Peng Q, Zheng Y, et al. Ox-LDL stimulates Id1 nucleocytoplasmic shuttling in endothelial cell angiogenesis via PI3K pathway［J］. Biochim Biophys Acta, 2012, 1821（10）: 1361-1369.
Qiu J, Wang G, Zheng Y, et al. Coordination of Id1 and p53 activation by oxidized LDL regulates endothelial cell proliferation and migration［J］. Ann Biomed Eng, 2011, 39（12）: 2869-2878.
Souilhol C, Serbanovic-Canic J, Fragiadaki M, et al. Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes［J］. Nat Rev Cardiol, 2020, 17（1）: 52-63.
Tarbell J M. Shear stress and the endothelial transport barrier［J］. Cardiovasc Res, 2010, 87（2）: 320-330.
Verhamme P, Yi B A, Segers A, et al. ANT-005 TKA Investigators. Abelacimab for prevention of venous thromboembolism［J］. N Engl J Med, 2021, 385（7）: 609-617.
Walther B K, Rajeeva N K, et al. Mechanotransduction-on-chip: vessel-chip model of endothelial YAP Mechanogy reveals matrix stiffness impedes shear response［J］. Lab Chip, 2021, 21（9）: 1738-1751.
Wang G X, Cai S X, Wang P Q, et al. Shear-induced changes in endothelin-1 secretion of microvascular endothelial cells［J］. Microvasc Res, 2002, 63（2）: 209-217.
Wang W, Ha C H, Jhun B S, et al. Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS［J］. Blood, 2010, 115（14）: 2971-2979.
Warabi E, Takabe W, Minami T, et al. Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species［J］. Free Radic Biol Med, 2007, 42（2）: 260-269.
Xu S, Xu Y, Liu P, et al. The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis［J］. Eur Heart J, 2019, 40（29）: 2398-2408.
Yoshizumi M, Abe J, Tsuchiya K, et al. Stress and vascular responses: atheroprotective effect of laminar fl uid shear stress in endothelial cells: possible role of mitogen-activated protein kinases［J］. J Pharmacol Sci, 2003, 91（3）: 172-176.
Yu S, Wong S L, Lau C W, et al. Oxidized LDL at low concentration promotes in-vitro angiogenesis and activates nitric oxide synthase through PI3K/Akt/eNOS pathway in human coronary artery endothelial cells［J］. Biochem Biophys Res Commun, 2011, 407（1）: 44-48.
Zhou T, Zheng Y, Qiu J, et al. Endothelial mechanotransduction mechanisms for vascular physiology and atherosclerosis［J］. J Mech Med Biol, 2014, 14（5）: 1-31.