参考文献
邱菊辉. Id1调控血管新生参与动脉粥样硬化易损斑块形成及其机制［D］. 重庆：重庆大学, 2011.
危当恒, 王贵学, 唐朝君, 等. 狭窄血管远心端低密度脂蛋白浓度极化促进动脉粥样硬化形成[J]. 生理学报, 2007（6）: 831-839.
张康. Id1调控脂质吸收参与动脉粥样硬化斑块形成的力学生物学机制［D］. 重庆：重庆大学, 2018.
张田. 基底硬度对人脐静脉内皮细胞黏附THP-1细胞及对其黏附相关分子表达的影响［D］. 重庆：重庆大学, 2016.
Ajami N E, Gupta S, Maurya M R, et al. Systems biology analysis of longitudinal functional response of endothelial cells to shear stress［J］. Proc Natl Acad Sci USA, 2017, 114（41）: 10990-10995.
Bäck M, Yurdagul A, Tabas I, et al. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities［J］. Nat Rev Cardiol, 2019, 16（7）: 389-406.
Baratchi S, Khoshmanesh K, Woodman O L, et al. Molecular sensors of blood flow in endothelial cells［J］. Trends Mol Med, 2017, 23（9）: 850-868.
Brown A J, Teng Z, Evans P C, et al. Role of biomechanical forces in the natural history of coronary atherosclerosis［J］. Nat Rev Cardiol, 2016, 13（4）: 210-220.
Brown M S, Goldstein J L. Receptor-mediated endocytosis: insights from the lipoprotein receptor system［J］. Proc Natl Acad Sci USA, 1979, 76（7）: 3330-3337.
Castañón E, Soltermann A, López I, et al. The inhibitor of differentiation-1（Id1）enables lung cancer liver colonization through activation of an EMT program in tumor cells and establishment of the pre-metastatic niche［J］. Cancer Lett, 2017, 402: 43-51.
Ciarrocchi A, Jankovic V, Shaked Y, et al. Id1 restrains p21 expression to control endothelial progenitor cell formation［J］. PLoS One, 2007, 2（12）: e1338.
Cohn J N. Arterial stiffness, vascular disease, and risk of cardiovascular events［J］. Circulation, 2006, 113（5）: 601-603.
Cuhlmann S, Heiden K, Saliba D, et al. Disturbed blood flow induces rela expression via c-jun n-terminal kinase 1: a novel mode of NF-kappaB regulation that promotes arterial inflammation［J］. Circ Res, 2011, 108（8）: 950-959.
Eberle D, Hegarty B, Bossard P, et al. SREBP transcription factors: master regulators of lipid homeostasis［J］. Biochimie, 2004, 86（11）: 839-848.
Fang J S, Coon B G, Gillis N, et al. Shear-induced notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification［J］. Nat Commun, 2017, 8（1）: 2149.
Farmer S R. Transcriptional control of adipocyte formation［J］. Cell Metabolism, 2006, 4（4）:263-273.
Feng S, Bowden N, Fragiadaki M, et al. Mechanical activation of hypoxia-inducible factor 1α drives endothelial dysfunction at atheroprone sites［J］. Arterioscler Thromb Vasc Biol, 2017, 37（11）: 2087-2101.
Gijsen F J, Wentzel J J, Thury A, et al. Strain distribution over plaques in human coronary arteries relates to shear stress［J］. Am J Physiol Heart Circ Physiol, 2008, 295（4）: H1608-1614.
Gimbrone M A Jr, García-Cardeña G. Endothelial cell dysfunction and the pathobiology of atherosclerosis［J］. Circ Res, 2016, 118（4）: 620-636.
Guo D, Chien S, Shyy J Y. Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and akt pathways［J］. Circ Res, 2007, 100（4）: 564-571.
Hua X, Yokoyama C, Wu J, et al. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element［J］. Proc Natl Acad Sci USA, 1993, 90（24）: 11603-11607.
Hu X M, Lin T, Huang X Y, et al. ID1 contributes to cell growth invasion and migration in salivary adenoid cystic carcinoma［J］. Mol Med Rep, 2017, 16（6）: 8907-8915.
Ivanova E A, Myasoedova V A, Melnichenko A A, et al. Small dense low-density lipoprotein as biomarker for atherosclerotic diseases［J］. Oxid Med Cell Longev, 2017, 2017: 1273042.
Jin X, Jin X, Kim L J Y, et al. Inhibition of ID1-BMPR2 intrinsic signaling sensitizes glioma stem cells to differentiation therapy［J］. Clin Cancer Res, 2018, 24（2）: 383-394.
Kumar S, Williams D, Sur S, et al. Role of flow-sensitive microRNAs and long noncoding RNAs in vascular dysfunction and atherosclerosis［J］. Vascul Pharmacol, 2019, 114: 76-92.
Lasorella A, Benezra R, Iavarone A. The id proteins: master regulators of cancer stem cells and tumour aggressiveness［J］. Nat Rev Cancer, 2014, 14（2）: 77-91.
Li R, Beebe T, Jen N, et al. Shear stress-activated wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos［J］. Arterioscler Thromb Vasc Biol, 2014, 34（10）:2268-2275.
Li Y S, Haga J H, Chien S. Molecular basis of the effects of shear stress on vascular endothelial cells［J］. J Biomech, 2005, 38（10）: 1949-1971.(https://www.daowen.com)
Mahmoud M M, Kim H R, Xing R, et al. TWIST1 integrates endothelial responses to flow in vascular dysfunction and atherosclerosis［J］. Circ Res, 2016, 119（3）: 450-462.
Maimari N. Integration of flow studies for robust selection of mechanoresponsive genes［J］. Thromb Haemost, 2016, 115: 474-483.
Maw M K, Fujimoto J, Tamaya T. Overexpression of inhibitor of DNA-binding（ID）-1 protein related to angiogenesis in tumor advancement of ovarian cancers［J］. BMC Cancer, 2009, 9: 430.
Moreno P R, Purushothaman K R, Fuster V, et al. Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability［J］. Circulation, 2004, 110（14）: 2032-2038.
Neto F, Klaus-Bergmann A, Ong Y T, et al. YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development［J］. Elife, 2018, 7: e31037.
Ni C W, Qiu H, Rezvan A, et al. Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow［J］. Blood, 2010, 116（15）: e66-73.
Patil M, Sharma B K, Satyanarayana A. Id transcriptional regulators in adipogenesis and adipose tissue metabolism［J］. Front Biosci（Landmark Ed）, 2014, 19: 1386-1397.
Pedrigi R M, Poulsen C B, Mehta V V, et al. Inducing persistent flow disturbances accelerates atherogenesis and promotes thin cap fibroatheroma development in D374Y-PCSK9 hypercholesterolemic minipigs［J］. Circulation, 2015, 132（11）: 1003-1012.
Rosen E D, Walkey C J, Puigserver P, et al. Transcriptional regulation of adipogenesis［J］. Genes Dev, 2000, 14（11）: 1293-1307.
Rosenson R S, Brewer H B, Ansell B J, et al. Dysfunctional HDL and atherosclerotic cardiovascular disease［J］. Nat Rev Cardiol, 2016, 13（1）: 48-60.
Ruzinova M B, Schoer R A, Gerald W, et al. Effect of angiogenesis inhibition by Id loss and the contribution of bonemarrow-derived endothelial cells in spontaneous murine tumors［J］. Cancer Cell, 2003, 4（4）: 277-289.
Satyanarayana A, Klarmann K D, Gavrilova O, et al. Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis［J］. Faseb J, 2012, 26（1）: 309-323.
Seale P, Kajimura S, Spiegelman B M. Transcriptional control of brown adipocyte development and physiological function of mice and men［J］. Genes Dev, 2009, 23（7）: 788-797.
Serbanovic-Canic J, Luca A, Warboys C, et al. Zebrafish model for functional screening of flow-responsive genes［J］. Arterioscler Thromb Vasc Biol, 2017, 37（1）: 130-143.
Shah R V, Murthy V L. Cardiac magnetic resonance detection of the human carotid: a new lens on neovascularization［J］. Atherosclerosis, 2016, 245: 60-61.
Sharma S, Plotkin M. Id1 expression in kidney endothelial cells protects against diabetes-induced microvascular injury［J］. FEBS Open Bio, 2020, 10（8）: 1447-1462.
Souilhol C, Serbanovic-Canic J, Fragiadaki M, et al. Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes［J］. Nat Rev Cardiol, 2020, 17（1）: 52-63.
Tressel S L, Huang R P, Tomsen N, et al. Laminar shear inhibits tubule formation and migration of endothelial cells by an angiopoietin-2–dependent mechanism［J］. ATVB, 2007, 27（10）: 2150-2156.
Verwoert G C, Franco O H, Hoeks A P, et al. Arterial stiffness and hypertension in a large population of untreated individuals: the rotterdam study［J］. J Hypertens, 2014, 32（8）: 1606-1612.
Volpert O V, Pili R, Sikder H A, et al. Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1［J］. Cancer Cell, 2002, 2（6）: 473-483.
Wada S, Karino T. Theoretical study on flow-dependent concentration polarization of low density lipoproteins at the luminal surface of a straight artery［J］. Biorheology, 1999, 36（3）: 207-223.
Wang G, Deng X, Guidoin R. Concentration polarization of macromolecules in canine carotid arteries and its implication for the localization of atherogenesis［J］. J Biomech. 2003, 36（1）: 45-51.
Wang K C, Yeh Y T, Nguyen P, et al. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis［J］. Proc Natl Acad Sci USA, 2016, 113（41）: 11525-11530.
Wang L, Luo J Y, Li B, et al. Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow［J］. Nature, 2016, 540（7634）: 579-582.
Wilkins M R, Sanchez J C, Gooley A A, et al. Progress with proteome projects: why all proteins expressed by a genome should be identified and how to do it［J］. Biotechnol Genet Eng Rev, 1996, 13: 19-50.
Yokoyama C, Wang X, Briggs M R, et al. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene［J］. Cell, 1993, 75（1）: 187-197.
Zhang K, Chen Y D, Zhang T, et al. A novel role of Id1 in regulating oscillatory shear stress-mediated lipid uptake in endothelial cells［J］. Ann Biomed Eng, 2018, 46（6）:849-863.