2.1.2.3　Management

There are two kinds of photoaging prevention measures，i.e.，photoprotection and medications that reverses skin damage.

1.Photoprotection

Photoprotection is a key primary preventative strategy，including wearing sun protective clothing，appropriate sunscreen application，and sun avoidance during peak ultraviolet times.

2.Medications(https://www.daowen.com)

（1）Topical retinoids：Tretinoin and tazarotene are the two topical vitamin A derivatives that are currently approved by the US FDA for the treatment of photoaging.They can promote collagen fiber production and improve clinical symptoms.

（2）5-fluorouracil cream：Topical 5-fluorouracil cream can be beneficial although it is not approved by the US FDA for photoaging management.It was reported that 5-fluorouracil could stimulate wound healing and subsequent dermal remodeling.

（3）Cosmeceuticals：Cosmeceuticals include antioxidants，soy，tea，ginkgo biloba，and ginseng.Antioxidants can scavenge free radicals and thus protect cells from damage，which include coenzyme Q，lipoic acid，and vitamins C and E.