8.5.3.3 Applications of MNs in transdermal adminis...
MNs based on biomedical polymers have been extensively studied in cosmetic field,skin inflammatory diseases,skin tumors,and skin infections(see the corresponding section for details).Table 8-1 summarizes the application studies of polymer MNs in the above fields in recent years(see extended reading 4).In these studies,polymer MNs generally exhibited a better preventive or therapeutic effect than traditional administration of vaccines or drugs.
Table 8-1 Summary of application of MNs based on biomedical polymers in skin diseases
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Note:ALA,a drug used in photodynamic therapy;a-PD1(anti-PD-1 antibody),a drug used in immunotherapy;HA(hyaluronic acid);MBA,N,N-methylenebis(acrylamide);1-MT(1-methyl-dl-tryptophan),an IDO inhibitor;CpG,a Toll-like receptor agonist with immune adjuvant effect;PEI(polyethylenimine);PVA(poly(vinyl alcohol));PVP(polyvinylpyrrolidone);PEG(polyethylene glycol);PGA(polyglycolic acid);CMC(carboxymethyl cellulose);m-HA/DE(methacrylate hyaluronic acid/diatomaceous earth);LaB6(lanthanum hexaboride);RR-PVA(reactive oxygen species(ROS)-responsive poly(vinyl alcohol));PCL(polycaprolactone);Gantrez AN-169:a copolymer of methyl vinyl ether and maleic anhydride;Gantrez S-97:a copolymer of methyl vinyl ether and maleic anhydride.(https://www.daowen.com)