5.4.2　Applications of RCM in the diagnosis of mela...

Cutaneous melanoma represents the challenges in early or preventive detection.In early stages of tumor development，surgical excision is almost always curative，whereas delayed recognition increases the risk of tumor growth and death from metastatic disease.RCM represents a breakthrough in melanoma diagnosis and biology of melanocytic lesions.Because melanosomes and melanin are strong sources of endogenous contrast，melanocytes are particularly evident by means of this technique.Several studies have identified RCM features of melanocytic lesions，suggesting that further improvement in diagnostic accuracy for melanoma could be achieved，especially when this technique is used in the combination with dermoscope.(https://www.daowen.com)