5.4.2.2　Lentigo maligna

Lentigo maligna（LM）is an early form of melanoma with an incidence that has increased during the past two decades.Several studies demonstrated that RCM can be used to differentiate LM from other pigmentations of the face.It can also assist in defining the peripheral margins of LM，even on amelanotic tumors.In 2010，Guitera et al.identified six features that were independently correlated with the diagnosis of LM by means of discriminant analysis，corresponding to，in order of relevance，nonedged papillae，large pagetoid round cells，nucleated cells in a dermal papilla，three or more atypical cells at the DEJ in five 0.5 mm×0.5 mm images，follicular localization of pagetoid cells and/or atypical junctional cells，and the single negative（benign）feature of a broadened honeycomb pattern of the epidermis（Figure 5-8）.(https://www.daowen.com)