6.5.2 Drug delivery routes of polymer nano-drug ca...
The main routes of drug delivery for polymer nano-drug carriers are injection and transdermal drug delivery.Since we are going to introduce the transdermal drug delivery of polymer nano-drug carriers in psoriasis treatment section，we will focus on relevant contents of the injection route for drug administration.Injection，characterized by high drug availability，refers to directly inject drugs to veins，organs，or tissues，which includes intravenous injection，intraperitoneal injection，intramuscular injection，subcutaneous injection，and others.In the study of drug delivery for melanoma，intravenous injection is mainly used，which includes intravenous injection and infusion.Different injection routes will influence the pharmacokinetic parameters and even the in vivo distribution of the polymer nano-drug carriers.Because the nano-drugs enter the circulatory system directly，their bioavailability is high.Yet，the adsorption of protein corona on the surfaces of nanomaterials will change their surface chemical and physical properties，resulting their blood clearance by the mononuclear phagocytic system in the body and their enrichment in liver，spleen and other organs，eventually leading to low tumor accumulation and toxic and side effects to some extent.This is also one of the key problems that researchers need to solve in the field of polymer nano-drug carriers.(https://www.daowen.com)