6.3 Preparation Technologies for Polymer Nano-Drug...
Until now，few technologies have been developed in the preparation of polymer nanodrug carriers.Drugs can be loaded on/inside polymer carriers via bonded/adsorbed with polymers，embedded into the matrix of polymer NPs，or encapsulated inside polymer nanocapsules/vesicles/nano-emulsions.Among them，three-dimensional macromolecules，such as dendritic polymer and albumin，can combine with drug molecules via physical or chemical interactions to obtain nano-drug delivery system.Physical interaction mainly includes van der Waals force，hydrogen bonding，electrostatic interaction and hydrophobic interaction.Chemical interaction includes ester bond，amido bond，hydrazone bond，etc.Other types of polymer nano-drug carriers，such as spherical micelles，vesicles，and nano-spheres/capsules，can be classified as polymer aggregates.According to the morphologies of aggregates，their preparation methods are shown as follows.(https://www.daowen.com)