参考文献
［1］Otto CM，Lind BK，Kitzman DW，et al.Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly［J］.N Engl J Med，1999，341：142-147.
［2］Stewart BF，Siscovick D，Lind BK，et al.Clinical factors associated with calcific aortic valve disease：Cardiovascular Health Study［J］.J Am Coll Cardiol，1997，29：630-634.
［3］Pan W，Zhou D，Cheng L，et al.Candidates for transcatheter aortic valve implantation may be fewer in China［J］.Int J Cardiol，2013；168（5）：e133-134.
［4］Pan W，Zhou D，Cheng L，et al.Aortic regurgitation is more prevalent than aortic stenosis in Chinese elderly population：Implications for transcatheter aortic valve replacement［J］.Int J Cardiol，2015；201：547-548.
［5］潘文志，李明飞，周达新，等.重度主动脉瓣狭窄患者二叶式主动脉瓣的超声心动图分析［J］.中华心血管病杂志，2015，43（03）：244-247.
［6］MoMer ER IH，Gannon F，Reynolds C，et al.Bone formation and inflammation in cardiac valves［J］.Circulation，2001，103：1522-1528.
［7］Otto CM.Calcific aortic stenosis —time to look more closely at the valve［J］.N Engl J Med，2008，359（13）：1395-1398.
［8］Cosmi JE，Kort S，Tunick PA，et al.The risk of the development of aortic stenosis in patients with“benign”aortic valve thickening［J］.Arch Intern Med，2002，162：2345-2347.
［9］Blaha MJ，Budoff MJ，Rivera JJ，et al.Relation of aortic valve calcium detected by cardiac computed tomography to all-cause mortality［J］.Am J Cardiol，2010，106（12）：1787-1791.
［10］Qian J，Chen Z，Ge J，et al.Relationship between aortic valve calcification and the severity of coronary atherosclerotic disease［J］.J Heart Valve Dis，2010，19（4）：466-470.
［11］Carabello BA.Aortic sclerosis：a window to the coronary arteries？［J］.N Engl J Med，1999，341：193-195.(https://www.daowen.com)
［12］King RM，Pluth JR，Giuliani ER.The association of unexplained gastrointestinal bleeding with calcific aortic stenosis［J］.Ann Thorac Surg，1987，44（5）：514-516.
［13］Leon MB，Smith CR，Mack M，et al.Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery［J］.N Engl J Med，2010，363：1597-1607.
［14］Pellikka PA，Sarano ME，Nishimura RA，et al.Outcome of 622 Adults With Asymptomatic，Hemodynamically Significant Aortic Stenosis During Prolonged Follow-Up［J］.Circulation，2005，111：3290-3295.
［15］Kang DH，Park SJ，Rim JH，et al.Early surgery versus conventional treatment in asymptomatic very severe aortic stenosis［J］.Circulation，2010，121（13）：1502-1509.
［16］Moura LM，Ramos SF，Zamorano JI，et al.Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis［J］.J Am Coll Cardiol，2007，49（5）：554-561.
［17］Cowell SJ，Newby DE，Prescott RJ，et al.A randomized trial of intensive lipid lowering therapy in calcific aortic stenosis［J］.N Engl J Med，2005，352（23）：2389-2397.
［18］Rosseba AB，Pedersen TR，Boman K，et al.Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis［J］.N Engl J Med，2008，359（13）：1343-1345.
［19］Skolnick AH，Osranek M，Formica P，et al.Osteoporosis treatment and progression of aortic stenosis.Am J Cardiol，2009，104（1）：122-124.
［20］Rosenhek R，Rader F，Loho N，et al.Statins but not angiotensin converting enzyme inhibitors delay progression of aortic stenosis.Circulation，2004，110（10）：1291-1292.
［21］O'Brien KD，Probstfield JL，Caulfield MT，et al. Angiotensin-converting enzyme inhibitors and change in aortic valve calcium［J］.Arch Intern Med，2005，165（8）：858-862.