九、小结

九、小结

在过去的50年中,通过开发和整合更有效和毒性更小的化疗方案,并持续改进手术切除技术,睾丸癌治疗领域经历了一个显著的演变过程。这些进展使超过90%的睾丸癌患者获得长久的治愈,同时减少了近期和远期的并发症。只有严格遵守既定的治疗原则,才能取得这些优异的成果。虽然对睾丸癌患者的治疗通常需要有经验丰富的多学科团队,但几乎每位睾丸癌患者的成功治疗都源于其泌尿外科医师。所有泌尿外科医师都应该对睾丸癌的合理治疗有一个全面而细致的了解。这种了解有助于确保提供合理的内科和外科治疗,同时必要时能够将患者及早转诊到具有大量病例诊疗经验的医疗中心进行进一步治疗。睾丸肿瘤手术治疗成功与否的衡量标准不仅包括预后结果,也包括尽可能保护功能和避免不必要的手术及减少并发症。

参考文献

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推荐阅读

Baniel J,Foster RS,Gonin R,et al.Late relapse of testicular cancer.J Clin Oncol 1995;13:1170-6.

Carver BS,Bianco FJ Jr,Shayegan B,et al.Predicting teratoma in the retroperitoneum in men undergoing postchemotherapy retroperitoneal lymph node dissection.J Urol 2006;176:100-3,discussion 103-4.

Carver BS,Shayegan B,Eggener S,et al.Incidence of metastatic nonseminomatous germ cell tumor outside the boundaries of a modifi ed postchemotherapy retroperitoneal lymph node dissection.J Clin Oncol 2007;25:4365-9.

Donohue JP,Leviovitch I,Foster RS,et al.Integration of surgery and systemic therapy:results and principles of integration.Semin Urol Oncol 1998;16:65-71.

Donohue JP,Thornhill JA,Foster RS,et al.Primary retroperitoneal lymph node dissection in clinical stage A nonseminomatous germ cell testis cancer.Review of the Indiana University experience 1965-1989.Br J Urol 1993;71:326-35.

Donohue JP,Zachary JM,Maynard BR.Distribution of nodal metastases in nonseminomatous testis cancer.J Urol 1982;128:315-20.

Eggener SE,Carver BS,Sharp DS,et al.Incidence of disease outside modifi ed retroperitoneal lymph node dissection templates in clinical stage I or IIA nonseminomatous germ cell testicular cancer.J Urol 2007;177:937-42,discussion 942-3.

Ehrlich Y,Brames MJ,Beck SD,et al.Long-term followup of cisplatin combination chemotherapy in patients with disseminated nonseminomatous germ cell tumors:is a postchemotherapy retroperitoneal lymph node dissection needed after complete remission?J Clin Oncol 2010;28:531-6.

Fizazi K,Tjulandin S,Salvioni R,et al.Viable malignant cells after primary chemotherapy for disseminated nonseminomatous germ cell tumors:prognostic factors and role of postsurgery chemotherapy-results from an international study group.J Clin Oncol 2001;19:2647-57.

Jewett MA,Kong YS,Goldberg SD,et al.Retroperitoneal lymphadenectomy for testis tumor with nerve sparing for ejaculation.J Urol 1988;139:1220-4.

Stephenson AJ,Bosl GJ,Motzer RJ,et al.Retroperitoneal lymph node dissection for nonseminomatous germ cell testicular cancer:impact of patient selection factors on outcome.J Clin Oncol 2005;23:2781-8.

Williams SD,Stablein DM,Einhorn LH,et al.Immediate adjuvant chemotherapy versus observation with treatment at relapse in pathological stageⅡtesticular cancer.N Engl J Med 1987;317:1433-8.

(何 宁 张 炎 编译 金晓东 陈向锋 审校)